ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	80/745	152/7206	7.50417152474e-40
ko04080	Neuroactive ligand-receptor interaction	134/745	423/7206	6.10334623754e-36
ko05033	Nicotine addiction	43/745	56/7206	7.03769771974e-32
ko04727	GABAergic synapse	56/745	110/7206	4.25160610091e-27
ko04713	Circadian entrainment	62/745	136/7206	1.71357199044e-26
ko04728	Dopaminergic synapse	73/745	185/7206	3.33048133768e-26
ko05032	Morphine addiction	55/745	110/7206	4.03701809125e-26
ko04723	Retrograde endocannabinoid signaling	64/745	175/7206	5.69641729968e-21
ko04024	cAMP signaling pathway	80/745	279/7206	2.00059082133e-18
ko04911	Insulin secretion	48/745	117/7206	2.23027942526e-18
ko05031	Amphetamine addiction	41/745	91/7206	1.21748576312e-17
ko04725	Cholinergic synapse	54/745	160/7206	4.47239554824e-16
ko05030	Cocaine addiction	34/745	73/7206	2.22624622421e-15
ko04020	Calcium signaling pathway	72/745	265/7206	2.71866659191e-15
ko04720	Long-term potentiation	39/745	99/7206	1.87578084597e-14
ko04261	Adrenergic signaling in cardiomyocytes	58/745	205/7206	2.45204025519e-13
ko04726	Serotonergic synapse	44/745	137/7206	1.84209573976e-12
ko04921	Oxytocin signaling pathway	57/745	209/7206	2.14901485507e-12
ko04721	Synaptic vesicle cycle	31/745	80/7206	1.5809373656e-11
ko04970	Salivary secretion	33/745	95/7206	1.10646409462e-10
ko04010	MAPK signaling pathway	71/745	321/7206	2.26435733138e-10
ko04925	Aldosterone synthesis and secretion	34/745	105/7206	5.0279873773e-10
ko04971	Gastric acid secretion	32/745	98/7206	1.29076614392e-09
ko05014	Amyotrophic lateral sclerosis (ALS)	26/745	74/7206	8.16267939662e-09
ko04742	Taste transduction	23/745	61/7206	1.27115325754e-08
ko04915	Estrogen signaling pathway	35/745	131/7206	7.58724462201e-08
ko04972	Pancreatic secretion	31/745	111/7206	1.4280637759e-07
ko04022	cGMP-PKG signaling pathway	46/745	216/7206	1.2451273493e-06
ko03040	Spliceosome	1/745	145/7206	3.13859959982e-06
ko04514	Cell adhesion molecules (CAMs)	31/745	130/7206	6.46730874367e-06
ko04730	Long-term depression	22/745	78/7206	7.82333272217e-06
ko04072	Phospholipase D signaling pathway	41/745	197/7206	1.27387584903e-05
ko05034	Alcoholism	46/745	238/7206	2.90680363742e-05
ko05168	Herpes simplex infection	4/745	182/7206	3.47992029112e-05
ko04740	Olfactory transduction	21/745	80/7206	4.13427797443e-05
ko04540	Gap junction	29/745	128/7206	4.50297326584e-05
ko05414	Dilated cardiomyopathy	26/745	112/7206	5.82911798459e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/745	79/7206	0.00010881578161
ko04360	Axon guidance	43/745	233/7206	0.000163323873527
ko04744	Phototransduction	12/745	36/7206	0.00016357728468
ko04924	Renin secretion	21/745	86/7206	0.000208266501696
ko04912	GnRH signaling pathway	26/745	122/7206	0.000263068654154
ko04621	NOD-like receptor signaling pathway	4/745	157/7206	0.000294180389923
ko04260	Cardiac muscle contraction	22/745	98/7206	0.00035194751384
ko05203	Viral carcinogenesis	12/745	277/7206	0.000376528282332
ko04015	Rap1 signaling pathway	48/745	278/7206	0.000383124969892
ko04070	Phosphatidylinositol signaling system	24/745	112/7206	0.000441721137587
ko05322	Systemic lupus erythematosus	4/745	151/7206	0.000601444016357
ko04750	Inflammatory mediator regulation of TRP channels	25/745	122/7206	0.000759752998539
ko04923	Regulation of lipolysis in adipocytes	18/745	77/7206	0.000890860170319
ko04918	Thyroid hormone synthesis	19/745	86/7206	0.00109560256031
ko04014	Ras signaling pathway	46/745	279/7206	0.00122977782165
ko04146	Peroxisome	1/745	89/7206	0.00124863411633
ko04371	Apelin signaling pathway	32/745	177/7206	0.00156236151488
ko03018	RNA degradation	1/745	84/7206	0.00181718771485
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/745	59/7206	0.00223893594289
ko04114	Oocyte meiosis	26/745	139/7206	0.00271268508869
ko04930	Type II diabetes mellitus	13/745	54/7206	0.00277326725139
ko04612	Antigen processing and presentation	1/745	77/7206	0.003988833274
ko00240	Pyrimidine metabolism	3/745	110/7206	0.00417155074535
ko04745	Phototransduction - fly	10/745	38/7206	0.00421500211106
ko04062	Chemokine signaling pathway	34/745	201/7206	0.00441257727287
ko04976	Bile secretion	17/745	80/7206	0.00444266850034
ko05231	Choline metabolism in cancer	24/745	134/7206	0.00620597017088
ko05164	Influenza A	7/745	167/7206	0.00637517691514
ko04120	Ubiquitin mediated proteolysis	5/745	138/7206	0.00661894458399
ko04270	Vascular smooth muscle contraction	27/745	154/7206	0.00677137517739
ko04626	Plant-pathogen interaction	6/745	18/7206	0.00746838350161
ko04916	Melanogenesis	25/745	142/7206	0.00749820184751
ko00512	Mucin type O-glycan biosynthesis	8/745	29/7206	0.00749837039792
ko05214	Glioma	16/745	79/7206	0.00789380675481
ko04630	Jak-STAT signaling pathway	5/745	132/7206	0.00885709644659
ko04973	Carbohydrate digestion and absorption	10/745	42/7206	0.00898545738176
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/745	14/7206	0.0105324020968
ko00190	Oxidative phosphorylation	5/745	127/7206	0.012058628576
ko04110	Cell cycle	6/745	145/7206	0.0121554760907
ko04071	Sphingolipid signaling pathway	27/745	162/7206	0.0123383609214
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/745	182/7206	0.0130851497025
ko04141	Protein processing in endoplasmic reticulum	9/745	184/7206	0.0133727285944
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/745	26/7206	0.0139497544487
ko03013	RNA transport	8/745	166/7206	0.0140247576671
ko03008	Ribosome biogenesis in eukaryotes	2/745	79/7206	0.0150810012448
ko04962	Vasopressin-regulated water reabsorption	12/745	58/7206	0.0157129624461
ko05016	Huntington's disease	12/745	215/7206	0.0167147629107
ko04722	Neurotrophin signaling pathway	26/745	160/7206	0.0176209807599
ko04550	Signaling pathways regulating pluripotency of stem cells	8/745	165/7206	0.018879818972
ko05410	Hypertrophic cardiomyopathy (HCM)	18/745	100/7206	0.018896828654
ko04142	Lysosome	7/745	151/7206	0.0204564292178
ko05162	Measles	5/745	120/7206	0.0223105791524
ko04012	ErbB signaling pathway	19/745	109/7206	0.0245526978714
ko05010	Alzheimer's disease	31/745	202/7206	0.0250365260337
ko04964	Proximal tubule bicarbonate reclamation	7/745	29/7206	0.0252229340838
ko05321	Inflammatory bowel disease (IBD)	1/745	56/7206	0.0268458044952
ko00310	Lysine degradation	2/745	73/7206	0.0310724993546
ko04960	Aldosterone-regulated sodium reabsorption	9/745	41/7206	0.0329987929583
ko04217	Necroptosis	10/745	178/7206	0.0337518293147
ko00513	Various types of N-glycan biosynthesis	9/745	42/7206	0.0353104309466
ko04320	Dorso-ventral axis formation	7/745	31/7206	0.035490164715
ko00515	Mannose type O-glycan biosynthesis	6/745	25/7206	0.0382248344453
ko00480	Glutathione metabolism	1/745	55/7206	0.0409955340079
ko04940	Type I diabetes mellitus	7/745	32/7206	0.041528025292
ko04064	NF-kappa B signaling pathway	4/745	96/7206	0.0424332693531
ko04137	Mitophagy - animal	3/745	82/7206	0.0437464470854
ko00650	Butanoate metabolism	6/745	26/7206	0.0455073584443
ko04213	Longevity regulating pathway - multiple species	15/745	86/7206	0.0468077322022
ko04016	MAPK signaling pathway - plant	5/745	20/7206	0.0485499568259
ko00430	Taurine and hypotaurine metabolism	4/745	14/7206	0.0488409223824