ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	182/1092	423/7206	2.23542275786e-46
ko05033	Nicotine addiction	47/1092	56/7206	2.45694075807e-30
ko04724	Glutamatergic synapse	81/1092	152/7206	1.76180213329e-28
ko05032	Morphine addiction	64/1092	110/7206	1.4275955985e-25
ko04727	GABAergic synapse	62/1092	110/7206	8.95783360128e-24
ko04728	Dopaminergic synapse	79/1092	185/7206	6.18183094939e-20
ko04713	Circadian entrainment	64/1092	136/7206	5.43147248732e-19
ko04024	cAMP signaling pathway	101/1092	279/7206	9.52479137547e-19
ko04721	Synaptic vesicle cycle	46/1092	80/7206	2.0549469487e-18
ko04723	Retrograde endocannabinoid signaling	72/1092	175/7206	3.49484419526e-17
ko04725	Cholinergic synapse	68/1092	160/7206	3.57425467734e-17
ko04360	Axon guidance	78/1092	233/7206	1.20006359742e-12
ko04742	Taste transduction	33/1092	61/7206	1.51285836031e-12
ko04911	Insulin secretion	49/1092	117/7206	2.00336842832e-12
ko04020	Calcium signaling pathway	84/1092	265/7206	4.91459640717e-12
ko04726	Serotonergic synapse	53/1092	137/7206	1.03467533603e-11
ko05031	Amphetamine addiction	38/1092	91/7206	6.9375151507e-10
ko04261	Adrenergic signaling in cardiomyocytes	65/1092	205/7206	1.26831470175e-09
ko03040	Spliceosome	1/1092	145/7206	1.377908095e-09
ko05203	Viral carcinogenesis	12/1092	277/7206	9.62584540622e-09
ko04921	Oxytocin signaling pathway	64/1092	209/7206	1.07994220095e-08
ko05030	Cocaine addiction	31/1092	73/7206	1.61655235812e-08
ko04744	Phototransduction	20/1092	36/7206	2.22500499469e-08
ko04720	Long-term potentiation	37/1092	99/7206	4.18498284102e-08
ko04060	Cytokine-cytokine receptor interaction	7/1092	191/7206	3.4750333689e-07
ko03013	RNA transport	5/1092	166/7206	4.6931892051e-07
ko04010	MAPK signaling pathway	82/1092	321/7206	6.43496485721e-07
ko04970	Salivary secretion	33/1092	95/7206	1.72018244831e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1092	74/7206	4.82093769335e-06
ko05168	Herpes simplex infection	8/1092	182/7206	4.96545489192e-06
ko05322	Systemic lupus erythematosus	6/1092	151/7206	1.60353940829e-05
ko04120	Ubiquitin mediated proteolysis	5/1092	138/7206	1.95431727201e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1092	79/7206	2.15735399643e-05
ko04022	cGMP-PKG signaling pathway	56/1092	216/7206	2.8583760493e-05
ko04514	Cell adhesion molecules (CAMs)	38/1092	130/7206	3.40967469564e-05
ko04621	NOD-like receptor signaling pathway	7/1092	157/7206	3.80185970998e-05
ko05164	Influenza A	8/1092	167/7206	4.0846127146e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1092	79/7206	5.20197892361e-05
ko04925	Aldosterone synthesis and secretion	32/1092	105/7206	5.35790769639e-05
ko04141	Protein processing in endoplasmic reticulum	10/1092	184/7206	6.07755487269e-05
ko04971	Gastric acid secretion	30/1092	98/7206	9.05874775982e-05
ko05169	Epstein-Barr virus infection	13/1092	206/7206	0.000107612487451
ko00240	Pyrimidine metabolism	4/1092	110/7206	0.000146673183713
ko03018	RNA degradation	2/1092	84/7206	0.00018762977748
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/1092	182/7206	0.000212181081832
ko04740	Olfactory transduction	25/1092	80/7206	0.00023132484929
ko01200	Carbon metabolism	6/1092	128/7206	0.000265609193331
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1092	14/7206	0.000346505895325
ko04924	Renin secretion	26/1092	86/7206	0.000367423329307
ko04540	Gap junction	35/1092	128/7206	0.000403032304915
ko04260	Cardiac muscle contraction	28/1092	98/7206	0.000559857925356
ko05414	Dilated cardiomyopathy	31/1092	112/7206	0.000735640963095
ko05162	Measles	6/1092	120/7206	0.000736964129313
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1092	59/7206	0.000819708161191
ko04014	Ras signaling pathway	63/1092	279/7206	0.000837033743461
ko05140	Leishmaniasis	2/1092	75/7206	0.000924271320769
ko04972	Pancreatic secretion	30/1092	111/7206	0.00116261808642
ko04730	Long-term depression	23/1092	78/7206	0.00118484264768
ko04064	NF-kappa B signaling pathway	4/1092	96/7206	0.00133644023529
ko00480	Glutathione metabolism	1/1092	55/7206	0.00208806209226
ko05321	Inflammatory bowel disease (IBD)	1/1092	56/7206	0.00214064052859
ko04072	Phospholipase D signaling pathway	46/1092	197/7206	0.00232612382157
ko04146	Peroxisome	4/1092	89/7206	0.00258244408119
ko04070	Phosphatidylinositol signaling system	29/1092	112/7206	0.0030906730103
ko00590	Arachidonic acid metabolism	1/1092	52/7206	0.00312653885759
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1092	26/7206	0.00319894143536
ko04966	Collecting duct acid secretion	10/1092	26/7206	0.00319894143536
ko04110	Cell cycle	10/1092	145/7206	0.00326916406809
ko00280	Valine, leucine and isoleucine degradation	1/1092	54/7206	0.00332559994218
ko04612	Antigen processing and presentation	3/1092	77/7206	0.00342552824455
ko04640	Hematopoietic cell lineage	2/1092	64/7206	0.00425532156235
ko05205	Proteoglycans in cancer	25/1092	271/7206	0.0042734734941
ko04391	Hippo signaling pathway - fly	24/1092	90/7206	0.00440486085047
ko04915	Estrogen signaling pathway	32/1092	131/7206	0.00449858022312
ko04630	Jak-STAT signaling pathway	9/1092	132/7206	0.00464915376997
ko00330	Arginine and proline metabolism	2/1092	61/7206	0.00614596055781
ko04214	Apoptosis - fly	3/1092	72/7206	0.00716667081769
ko04950	Maturity onset diabetes of the young	10/1092	29/7206	0.00785354885156
ko05145	Toxoplasmosis	9/1092	126/7206	0.00830474968813
ko00515	Mannose type O-glycan biosynthesis	9/1092	25/7206	0.00841491062909
ko05146	Amoebiasis	6/1092	99/7206	0.0101861265803
ko03022	Basal transcription factors	1/1092	44/7206	0.0104385236941
ko05144	Malaria	1/1092	45/7206	0.0106345486107
ko00071	Fatty acid degradation	1/1092	45/7206	0.0106345486107
ko04976	Bile secretion	21/1092	80/7206	0.0109209367627
ko03420	Nucleotide excision repair	1/1092	46/7206	0.0111479421968
ko05110	Vibrio cholerae infection	17/1092	63/7206	0.0129235818454
ko04015	Rap1 signaling pathway	57/1092	278/7206	0.0133312886561
ko05418	Fluid shear stress and atherosclerosis	15/1092	173/7206	0.0134250110015
ko05131	Shigellosis	5/1092	82/7206	0.0191768147271
ko04930	Type II diabetes mellitus	15/1092	54/7206	0.0198147353458
ko00600	Sphingolipid metabolism	3/1092	63/7206	0.0199880702504
ko04750	Inflammatory mediator regulation of TRP channels	28/1092	122/7206	0.0211512595659
ko00630	Glyoxylate and dicarboxylate metabolism	1/1092	38/7206	0.0231529735835
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1092	40/7206	0.0239358739989
ko05219	Bladder cancer	2/1092	48/7206	0.026495027315
ko00380	Tryptophan metabolism	2/1092	50/7206	0.0270486814176
ko04140	Autophagy - animal	15/1092	164/7206	0.0275015812419
ko05161	Hepatitis B	16/1092	173/7206	0.0310596379459
ko04964	Proximal tubule bicarbonate reclamation	9/1092	29/7206	0.0319408378937
ko01230	Biosynthesis of amino acids	6/1092	85/7206	0.0329991518277
ko05133	Pertussis	6/1092	87/7206	0.0336186973806
ko04371	Apelin signaling pathway	37/1092	177/7206	0.0339437595496
ko05034	Alcoholism	48/1092	238/7206	0.0340521112059
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1092	100/7206	0.0343976997106
ko00982	Drug metabolism - cytochrome P450	1/1092	37/7206	0.0351195428893
ko01524	Platinum drug resistance	5/1092	76/7206	0.0355163835107
ko04142	Lysosome	14/1092	151/7206	0.0391311319526
ko04962	Vasopressin-regulated water reabsorption	15/1092	58/7206	0.0402789665565
ko05016	Huntington's disease	22/1092	215/7206	0.0422097962987
ko04137	Mitophagy - animal	6/1092	82/7206	0.0441538227633
ko04620	Toll-like receptor signaling pathway	8/1092	100/7206	0.048129447337
ko00010	Glycolysis / Gluconeogenesis	5/1092	74/7206	0.0485980157714