ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 49/285 423/7206 4.14280483018e-12 ko04070 Phosphatidylinositol signaling system 22/285 112/7206 2.9235591923e-10 ko05033 Nicotine addiction 13/285 56/7206 1.8069457913e-07 ko04020 Calcium signaling pathway 29/285 265/7206 5.06899690168e-07 ko04072 Phospholipase D signaling pathway 22/285 197/7206 9.28417496286e-06 ko04724 Glutamatergic synapse 18/285 152/7206 2.78878810216e-05 ko00562 Inositol phosphate metabolism 13/285 89/7206 4.15802386613e-05 ko05032 Morphine addiction 14/285 110/7206 0.00010009929641 ko04721 Synaptic vesicle cycle 11/285 80/7206 0.000280825770299 ko04713 Circadian entrainment 15/285 136/7206 0.000289185919281 ko04727 GABAergic synapse 13/285 110/7206 0.000372665959608 ko04725 Cholinergic synapse 16/285 160/7206 0.000557562011904 ko04010 MAPK signaling pathway 26/285 321/7206 0.000565701460193 ko05231 Choline metabolism in cancer 14/285 134/7206 0.00079460658422 ko04925 Aldosterone synthesis and secretion 12/285 105/7206 0.000844310721029 ko04728 Dopaminergic synapse 17/285 185/7206 0.00151320867759 ko04024 cAMP signaling pathway 22/285 279/7206 0.00235818413303 ko04726 Serotonergic synapse 13/285 137/7206 0.00289857447945 ko04723 Retrograde endocannabinoid signaling 15/285 175/7206 0.00460888924992 ko04921 Oxytocin signaling pathway 17/285 209/7206 0.00557236037035 ko04071 Sphingolipid signaling pathway 14/285 162/7206 0.00611392972487 ko04144 Endocytosis 24/285 342/7206 0.00619375376247 ko04666 Fc gamma R-mediated phagocytosis 11/285 122/7206 0.0086879918778 ko04742 Taste transduction 7/285 61/7206 0.00985366377363 ko05168 Herpes simplex infection 1/285 182/7206 0.0106167302051 ko04730 Long-term depression 8/285 78/7206 0.0115408263566 ko04970 Salivary secretion 9/285 95/7206 0.0124890878395 ko04744 Phototransduction 5/285 36/7206 0.0128837057088 ko05164 Influenza A 1/285 167/7206 0.0150208847552 ko04971 Gastric acid secretion 9/285 98/7206 0.0151024676713 ko04720 Long-term potentiation 9/285 99/7206 0.0160571686588 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/285 14/7206 0.0161132934295 ko04966 Collecting duct acid secretion 4/285 26/7206 0.0180147129026 ko04514 Cell adhesion molecules (CAMs) 11/285 130/7206 0.0186602569701 ko04911 Insulin secretion 10/285 117/7206 0.0256844172067 ko05203 Viral carcinogenesis 4/285 277/7206 0.0262316008801 ko05031 Amphetamine addiction 8/285 91/7206 0.0270206420149 ko04750 Inflammatory mediator regulation of TRP channels 10/285 122/7206 0.0292691625111 ko04022 cGMP-PKG signaling pathway 15/285 216/7206 0.0313510304438 ko05322 Systemic lupus erythematosus 1/285 151/7206 0.0317849483277 ko04060 Cytokine-cytokine receptor interaction 2/285 191/7206 0.0356897078687 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/285 1/7206 0.0395503746879