ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1050	423/7206	3.09929092979e-46
ko04724	Glutamatergic synapse	82/1050	152/7206	1.44001167266e-30
ko05033	Nicotine addiction	46/1050	56/7206	1.14580447572e-29
ko04713	Circadian entrainment	68/1050	136/7206	5.60163576404e-23
ko04727	GABAergic synapse	59/1050	110/7206	4.38620817916e-22
ko05032	Morphine addiction	59/1050	110/7206	4.38620817916e-22
ko04728	Dopaminergic synapse	79/1050	185/7206	5.08092500981e-21
ko04725	Cholinergic synapse	70/1050	160/7206	1.89523368803e-19
ko04721	Synaptic vesicle cycle	45/1050	80/7206	3.29102883296e-18
ko04723	Retrograde endocannabinoid signaling	71/1050	175/7206	1.62756100517e-17
ko04024	cAMP signaling pathway	91/1050	279/7206	6.68037448009e-15
ko04742	Taste transduction	34/1050	61/7206	6.61590324296e-14
ko04921	Oxytocin signaling pathway	73/1050	209/7206	7.08645306274e-14
ko04020	Calcium signaling pathway	84/1050	265/7206	4.96194197581e-13
ko04726	Serotonergic synapse	54/1050	137/7206	5.44905516344e-13
ko04911	Insulin secretion	47/1050	117/7206	8.09987367594e-12
ko04720	Long-term potentiation	41/1050	99/7206	5.68859935585e-11
ko05031	Amphetamine addiction	38/1050	91/7206	2.16140459512e-10
ko04744	Phototransduction	21/1050	36/7206	1.40691672198e-09
ko04261	Adrenergic signaling in cardiomyocytes	63/1050	205/7206	2.11908898522e-09
ko05203	Viral carcinogenesis	11/1050	277/7206	9.23937229666e-09
ko04970	Salivary secretion	35/1050	95/7206	5.40657296964e-08
ko03040	Spliceosome	2/1050	145/7206	6.54124486013e-08
ko04740	Olfactory transduction	31/1050	80/7206	8.16520332737e-08
ko04060	Cytokine-cytokine receptor interaction	6/1050	191/7206	2.086690532e-07
ko05168	Herpes simplex infection	6/1050	182/7206	6.38283959519e-07
ko04925	Aldosterone synthesis and secretion	35/1050	105/7206	9.5543721187e-07
ko05322	Systemic lupus erythematosus	4/1050	151/7206	1.78468971147e-06
ko04621	NOD-like receptor signaling pathway	5/1050	157/7206	3.26115904608e-06
ko04971	Gastric acid secretion	32/1050	98/7206	4.51090928219e-06
ko04360	Axon guidance	60/1050	233/7206	4.75693631551e-06
ko04010	MAPK signaling pathway	77/1050	321/7206	4.77663638699e-06
ko05030	Cocaine addiction	26/1050	73/7206	5.77013054205e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1050	74/7206	7.6829581153e-06
ko04730	Long-term depression	27/1050	78/7206	1.14102592481e-05
ko04514	Cell adhesion molecules (CAMs)	38/1050	130/7206	1.33974697788e-05
ko05164	Influenza A	7/1050	167/7206	1.91582296277e-05
ko04022	cGMP-PKG signaling pathway	55/1050	216/7206	2.01009454725e-05
ko03013	RNA transport	7/1050	166/7206	2.82295094905e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1050	79/7206	3.26869519572e-05
ko04745	Phototransduction - fly	16/1050	38/7206	3.45447699834e-05
ko04110	Cell cycle	6/1050	145/7206	6.95650966445e-05
ko04610	Complement and coagulation cascades	1/1050	79/7206	8.27913631298e-05
ko05169	Epstein-Barr virus infection	12/1050	206/7206	0.000118226587959
ko04260	Cardiac muscle contraction	29/1050	98/7206	0.000122431876866
ko04120	Ubiquitin mediated proteolysis	6/1050	138/7206	0.000204230797075
ko04064	NF-kappa B signaling pathway	3/1050	96/7206	0.000380569401452
ko04141	Protein processing in endoplasmic reticulum	11/1050	184/7206	0.000414386304294
ko05166	HTLV-I infection	23/1050	292/7206	0.000493370996601
ko04966	Collecting duct acid secretion	11/1050	26/7206	0.000561229556054
ko04972	Pancreatic secretion	30/1050	111/7206	0.00056997420775
ko04070	Phosphatidylinositol signaling system	30/1050	112/7206	0.000627963714277
ko03008	Ribosome biogenesis in eukaryotes	2/1050	79/7206	0.000629079893455
ko04612	Antigen processing and presentation	2/1050	77/7206	0.000930994078096
ko05161	Hepatitis B	11/1050	173/7206	0.000989049810842
ko04014	Ras signaling pathway	60/1050	279/7206	0.00132344292858
ko05140	Leishmaniasis	2/1050	75/7206	0.0014002457892
ko04964	Proximal tubule bicarbonate reclamation	11/1050	29/7206	0.00165494798115
ko04072	Phospholipase D signaling pathway	45/1050	197/7206	0.00195874062486
ko04214	Apoptosis - fly	2/1050	72/7206	0.00203816322522
ko04976	Bile secretion	22/1050	80/7206	0.00220054720962
ko04626	Plant-pathogen interaction	8/1050	18/7206	0.00221924664839
ko04915	Estrogen signaling pathway	32/1050	131/7206	0.00247425981212
ko05205	Proteoglycans in cancer	23/1050	271/7206	0.00275221292886
ko04924	Renin secretion	23/1050	86/7206	0.00299516636157
ko00480	Glutathione metabolism	1/1050	55/7206	0.00326328827562
ko04540	Gap junction	31/1050	128/7206	0.00336369887161
ko04371	Apelin signaling pathway	40/1050	177/7206	0.00345974492894
ko04146	Peroxisome	4/1050	89/7206	0.00374024813826
ko05162	Measles	7/1050	120/7206	0.00385739490923
ko04657	IL-17 signaling pathway	4/1050	87/7206	0.00532164430397
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1050	100/7206	0.00600308556947
ko04330	Notch signaling pathway	2/1050	62/7206	0.00616920210607
ko05414	Dilated cardiomyopathy	27/1050	112/7206	0.00652830639051
ko04922	Glucagon signaling pathway	30/1050	128/7206	0.00737494312152
ko04350	TGF-beta signaling pathway	6/1050	103/7206	0.00739468363197
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1050	14/7206	0.00993759246832
ko05110	Vibrio cholerae infection	17/1050	63/7206	0.0104779470422
ko04930	Type II diabetes mellitus	15/1050	54/7206	0.0105106073441
ko03420	Nucleotide excision repair	1/1050	46/7206	0.0107090489219
ko05200	Pathways in cancer	53/1050	492/7206	0.011875096949
ko05321	Inflammatory bowel disease (IBD)	2/1050	56/7206	0.0129710435455
ko00240	Pyrimidine metabolism	7/1050	110/7206	0.0133143749696
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1050	182/7206	0.0138590423921
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1050	59/7206	0.0140245235945
ko04973	Carbohydrate digestion and absorption	12/1050	42/7206	0.0153861201238
ko03022	Basal transcription factors	1/1050	44/7206	0.016204649832
ko05144	Malaria	1/1050	45/7206	0.0169369911018
ko04217	Necroptosis	15/1050	178/7206	0.0174950710626
ko04630	Jak-STAT signaling pathway	10/1050	132/7206	0.0178887981329
ko03018	RNA degradation	5/1050	84/7206	0.01947202379
ko04640	Hematopoietic cell lineage	3/1050	64/7206	0.0198865218285
ko04115	p53 signaling pathway	4/1050	74/7206	0.0199906978842
ko01524	Platinum drug resistance	4/1050	76/7206	0.0205230939477
ko00562	Inositol phosphate metabolism	21/1050	89/7206	0.0221573117058
ko04510	Focal adhesion	23/1050	240/7206	0.0252276478675
ko04668	TNF signaling pathway	9/1050	120/7206	0.0258118755651
ko04750	Inflammatory mediator regulation of TRP channels	27/1050	122/7206	0.026620367617
ko00330	Arginine and proline metabolism	3/1050	61/7206	0.0279660208946
ko04622	RIG-I-like receptor signaling pathway	3/1050	62/7206	0.0282748229764
ko05215	Prostate cancer	8/1050	111/7206	0.0288161511033
ko04210	Apoptosis	16/1050	180/7206	0.0315853598649
ko05222	Small cell lung cancer	6/1050	89/7206	0.0335861197387
ko04341	Hedgehog signaling pathway - fly	1/1050	38/7206	0.0352536412725
ko03410	Base excision repair	1/1050	38/7206	0.0352536412725
ko05217	Basal cell carcinoma	4/1050	68/7206	0.0380353027568
ko04912	GnRH signaling pathway	26/1050	122/7206	0.0382589210158
ko04978	Mineral absorption	11/1050	40/7206	0.0385051887168
ko00260	Glycine, serine and threonine metabolism	2/1050	48/7206	0.0386733398316
ko04658	Th1 and Th2 cell differentiation	7/1050	96/7206	0.0409476193861
ko04550	Signaling pathways regulating pluripotency of stem cells	15/1050	165/7206	0.0441160745898
ko05133	Pertussis	6/1050	87/7206	0.0452880032895
ko05202	Transcriptional misregulation in cancer	18/1050	188/7206	0.0468908374103
ko05418	Fluid shear stress and atherosclerosis	16/1050	173/7206	0.0488154282113
ko05016	Huntington's disease	21/1050	215/7206	0.0489166183577
ko04710	Circadian rhythm	11/1050	43/7206	0.0496479787882