ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 27/284 191/7206 5.53077547752e-09 ko04380 Osteoclast differentiation 21/284 134/7206 4.83181087457e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/284 191/7206 1.48014752759e-06 ko05164 Influenza A 21/284 167/7206 2.12790444184e-06 ko05162 Measles 17/284 120/7206 4.00718486324e-06 ko05160 Hepatitis C 19/284 153/7206 7.92730439206e-06 ko04610 Complement and coagulation cascades 13/284 79/7206 1.07177907464e-05 ko04620 Toll-like receptor signaling pathway 14/284 100/7206 3.30466818882e-05 ko04710 Circadian rhythm 9/284 43/7206 3.49866708858e-05 ko05161 Hepatitis B 19/284 173/7206 4.60686223783e-05 ko05321 Inflammatory bowel disease (IBD) 10/284 56/7206 5.49930364635e-05 ko04668 TNF signaling pathway 15/284 120/7206 6.72089325561e-05 ko04621 NOD-like receptor signaling pathway 17/284 157/7206 0.000138236608707 ko04066 HIF-1 signaling pathway 14/284 123/7206 0.000319671603723 ko04658 Th1 and Th2 cell differentiation 12/284 96/7206 0.000359260523861 ko04064 NF-kappa B signaling pathway 12/284 96/7206 0.000359260523861 ko05215 Prostate cancer 13/284 111/7206 0.000393894484318 ko04650 Natural killer cell mediated cytotoxicity 12/284 97/7206 0.000395838907251 ko04672 Intestinal immune network for IgA production 7/284 37/7206 0.000510242284549 ko04622 RIG-I-like receptor signaling pathway 9/284 62/7206 0.000652700408991 ko05168 Herpes simplex infection 17/284 182/7206 0.000795605151919 ko04660 T cell receptor signaling pathway 13/284 124/7206 0.00113888678782 ko05145 Toxoplasmosis 13/284 126/7206 0.00132113415058 ko05152 Tuberculosis 17/284 187/7206 0.00156926704525 ko04630 Jak-STAT signaling pathway 13/284 132/7206 0.00201922795894 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/284 135/7206 0.00246861704529 ko05323 Rheumatoid arthritis 10/284 89/7206 0.0024977810487 ko05140 Leishmaniasis 9/284 75/7206 0.00258530037034 ko04062 Chemokine signaling pathway 17/284 201/7206 0.00263833828785 ko04659 Th17 cell differentiation 11/284 106/7206 0.00292092347857 ko05230 Central carbon metabolism in cancer 9/284 81/7206 0.00437337085066 ko00140 Steroid hormone biosynthesis 6/284 41/7206 0.00499569720214 ko00051 Fructose and mannose metabolism 6/284 42/7206 0.00564002951163 ko04152 AMPK signaling pathway 14/284 161/7206 0.00580962466913 ko05340 Primary immunodeficiency 5/284 30/7206 0.00581715872918 ko04611 Platelet activation 14/284 163/7206 0.00620523110548 ko00120 Primary bile acid biosynthesis 4/284 20/7206 0.00694236567655 ko04664 Fc epsilon RI signaling pathway 8/284 77/7206 0.0105011972633 ko04931 Insulin resistance 12/284 137/7206 0.0114723747409 ko05150 Staphylococcus aureus infection 5/284 36/7206 0.0127032323105 ko04711 Circadian rhythm - fly 3/284 13/7206 0.0129120276853 ko00590 Arachidonic acid metabolism 6/284 52/7206 0.0157854737847 ko05212 Pancreatic cancer 8/284 83/7206 0.0160910268177 ko04015 Rap1 signaling pathway 19/284 278/7206 0.0173661556054 ko03320 PPAR signaling pathway 7/284 69/7206 0.0183521953525 ko05142 Chagas disease (American trypanosomiasis) 11/284 130/7206 0.018430152676 ko05133 Pertussis 8/284 87/7206 0.0208492113763 ko04960 Aldosterone-regulated sodium reabsorption 5/284 41/7206 0.0215427975519 ko04623 Cytosolic DNA-sensing pathway 5/284 41/7206 0.0215427975519 ko04662 B cell receptor signaling pathway 8/284 88/7206 0.0221798614382 ko04068 FoxO signaling pathway 13/284 167/7206 0.0233970904767 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/284 92/7206 0.0281036329041 ko04919 Thyroid hormone signaling pathway 11/284 143/7206 0.0283132908266 ko04666 Fc gamma R-mediated phagocytosis 10/284 122/7206 0.0289167436338 ko04217 Necroptosis 13/284 178/7206 0.0292926573786 ko05144 Malaria 5/284 45/7206 0.0309504403455 ko04922 Glucagon signaling pathway 10/284 128/7206 0.0348336110912 ko00592 alpha-Linolenic acid metabolism 3/284 19/7206 0.0367722369888 ko05131 Shigellosis 7/284 82/7206 0.042167213271 ko04137 Mitophagy - animal 7/284 82/7206 0.042167213271 ko05169 Epstein-Barr virus infection 14/284 206/7206 0.0432052138628 ko04120 Ubiquitin mediated proteolysis 1/284 138/7206 0.0449894997865 ko04723 Retrograde endocannabinoid signaling 2/284 175/7206 0.0488830966817 ko05016 Huntington's disease 3/284 215/7206 0.0491701541526 ko04310 Wnt signaling pathway 2/284 181/7206 0.0497594156691