ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 8/50 56/7206 3.30687368962e-09 ko04728 Dopaminergic synapse 10/50 185/7206 4.10988938025e-07 ko04713 Circadian entrainment 8/50 136/7206 3.60660869894e-06 ko04730 Long-term depression 6/50 78/7206 1.44087796401e-05 ko04080 Neuroactive ligand-receptor interaction 12/50 423/7206 2.25658622113e-05 ko04723 Retrograde endocannabinoid signaling 8/50 175/7206 2.31692438051e-05 ko05031 Amphetamine addiction 6/50 91/7206 3.49238621904e-05 ko04720 Long-term potentiation 6/50 99/7206 5.6292286899e-05 ko04724 Glutamatergic synapse 7/50 152/7206 7.5529652591e-05 ko04721 Synaptic vesicle cycle 5/50 80/7206 0.000213054964248 ko04727 GABAergic synapse 5/50 110/7206 0.000927966312473 ko04911 Insulin secretion 5/50 117/7206 0.00122497155396 ko04010 MAPK signaling pathway 8/50 321/7206 0.00148349336409 ko05030 Cocaine addiction 4/50 73/7206 0.00157012496153 ko05014 Amyotrophic lateral sclerosis (ALS) 4/50 74/7206 0.00165142955781 ko04020 Calcium signaling pathway 7/50 265/7206 0.0021651177214 ko04015 Rap1 signaling pathway 7/50 278/7206 0.002837481085 ko04024 cAMP signaling pathway 7/50 279/7206 0.00289519405025 ko04925 Aldosterone synthesis and secretion 4/50 105/7206 0.00586234340598 ko05032 Morphine addiction 4/50 110/7206 0.00690315370631 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/50 1/7206 0.00693866222591 ko04961 Endocrine and other factor-regulated calcium reabsorption 3/50 59/7206 0.00777932105972 ko04540 Gap junction 4/50 128/7206 0.0116469785486 ko04970 Salivary secretion 3/50 95/7206 0.0278455984322 ko04971 Gastric acid secretion 3/50 98/7206 0.0301608241456 ko04960 Aldosterone-regulated sodium reabsorption 2/50 41/7206 0.0325771465137