ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 19/399 112/7206 1.02703150663e-05 ko04060 Cytokine-cytokine receptor interaction 26/399 191/7206 1.65837983642e-05 ko04650 Natural killer cell mediated cytotoxicity 16/399 97/7206 7.30433587856e-05 ko04921 Oxytocin signaling pathway 25/399 209/7206 0.000282603567345 ko04610 Complement and coagulation cascades 13/399 79/7206 0.000352247634583 ko04710 Circadian rhythm 9/399 43/7206 0.000468427120113 ko04020 Calcium signaling pathway 29/399 265/7206 0.000483016042702 ko04621 NOD-like receptor signaling pathway 20/399 157/7206 0.000505444201446 ko00120 Primary bile acid biosynthesis 6/399 20/7206 0.00055341716432 ko04666 Fc gamma R-mediated phagocytosis 16/399 122/7206 0.00106311433176 ko04217 Necroptosis 21/399 178/7206 0.00119367648162 ko04380 Osteoclast differentiation 17/399 134/7206 0.00154393404959 ko00051 Fructose and mannose metabolism 8/399 42/7206 0.00184312925291 ko04022 cGMP-PKG signaling pathway 23/399 216/7206 0.00221483774848 ko04922 Glucagon signaling pathway 16/399 128/7206 0.00241533873081 ko05164 Influenza A 19/399 167/7206 0.002847363787 ko05321 Inflammatory bowel disease (IBD) 9/399 56/7206 0.00332814665839 ko05162 Measles 15/399 120/7206 0.0034618031205 ko05031 Amphetamine addiction 12/399 91/7206 0.00416605726761 ko04611 Platelet activation 18/399 163/7206 0.00470100047218 ko05230 Central carbon metabolism in cancer 11/399 81/7206 0.00476612581994 ko03040 Spliceosome 1/399 145/7206 0.00490013745301 ko04110 Cell cycle 1/399 145/7206 0.00490013745301 ko04670 Leukocyte transendothelial migration 17/399 151/7206 0.00566332721692 ko04960 Aldosterone-regulated sodium reabsorption 7/399 41/7206 0.00662853551119 ko04925 Aldosterone synthesis and secretion 13/399 105/7206 0.00747016626121 ko04725 Cholinergic synapse 17/399 160/7206 0.00818394545515 ko04066 HIF-1 signaling pathway 14/399 123/7206 0.0086588821374 ko03013 RNA transport 2/399 166/7206 0.00882871412183 ko04662 B cell receptor signaling pathway 11/399 88/7206 0.00890696987789 ko03010 Ribosome 1/399 129/7206 0.0101541898871 ko04072 Phospholipase D signaling pathway 20/399 197/7206 0.0101989288579 ko05231 Choline metabolism in cancer 15/399 134/7206 0.011045369432 ko05214 Glioma 10/399 79/7206 0.0113556460554 ko04068 FoxO signaling pathway 17/399 167/7206 0.0147930989039 ko00562 Inositol phosphate metabolism 11/399 89/7206 0.0157606228577 ko05161 Hepatitis B 17/399 173/7206 0.0179801531134 ko00592 alpha-Linolenic acid metabolism 4/399 19/7206 0.0184909710144 ko04630 Jak-STAT signaling pathway 14/399 132/7206 0.0186242895725 ko04064 NF-kappa B signaling pathway 11/399 96/7206 0.0206273257476 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/399 135/7206 0.0207976322152 ko05152 Tuberculosis 18/399 187/7206 0.0215234420602 ko04152 AMPK signaling pathway 16/399 161/7206 0.0215824825342 ko04971 Gastric acid secretion 11/399 98/7206 0.0227004608985 ko05340 Primary immunodeficiency 5/399 30/7206 0.0229962003498 ko04668 TNF signaling pathway 13/399 120/7206 0.0232981162121 ko00590 Arachidonic acid metabolism 7/399 52/7206 0.023468311279 ko00140 Steroid hormone biosynthesis 6/399 41/7206 0.0240776122747 ko04750 Inflammatory mediator regulation of TRP channels 13/399 122/7206 0.024540126889 ko05160 Hepatitis C 15/399 153/7206 0.02963093985 ko05140 Leishmaniasis 9/399 75/7206 0.035604388483 ko04664 Fc epsilon RI signaling pathway 9/399 77/7206 0.037782514417 ko04919 Thyroid hormone signaling pathway 14/399 143/7206 0.0387695739722 ko04350 TGF-beta signaling pathway 1/399 103/7206 0.0459299825026 ko05150 Staphylococcus aureus infection 5/399 36/7206 0.0465030261783 ko01040 Biosynthesis of unsaturated fatty acids 4/399 25/7206 0.0465436451347 ko04659 Th17 cell differentiation 11/399 106/7206 0.0486933646745