ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 16/179 112/7206 1.2793310197e-08 ko00562 Inositol phosphate metabolism 12/179 89/7206 1.7125424941e-06 ko04724 Glutamatergic synapse 14/179 152/7206 2.23662032469e-05 ko04925 Aldosterone synthesis and secretion 11/179 105/7206 5.35637581477e-05 ko04727 GABAergic synapse 11/179 110/7206 8.23064639583e-05 ko05032 Morphine addiction 11/179 110/7206 8.23064639583e-05 ko05231 Choline metabolism in cancer 12/179 134/7206 0.000114962402777 ko04062 Chemokine signaling pathway 15/179 201/7206 0.00013188844077 ko04713 Circadian entrainment 12/179 136/7206 0.000132543876212 ko04911 Insulin secretion 11/179 117/7206 0.00014408172574 ko04725 Cholinergic synapse 13/179 160/7206 0.000161052106146 ko04072 Phospholipase D signaling pathway 14/179 197/7206 0.000367821525841 ko04915 Estrogen signaling pathway 11/179 131/7206 0.000389951555555 ko04723 Retrograde endocannabinoid signaling 13/179 175/7206 0.000390125487568 ko04750 Inflammatory mediator regulation of TRP channels 10/179 122/7206 0.000865969852867 ko04666 Fc gamma R-mediated phagocytosis 10/179 122/7206 0.000865969852867 ko04211 Longevity regulating pathway 10/179 123/7206 0.000922697758812 ko04371 Apelin signaling pathway 12/179 177/7206 0.00145679562387 ko04270 Vascular smooth muscle contraction 11/179 154/7206 0.00150716123774 ko04726 Serotonergic synapse 10/179 137/7206 0.00209248055983 ko04728 Dopaminergic synapse 12/179 185/7206 0.0021203951208 ko05033 Nicotine addiction 6/179 56/7206 0.00250363354571 ko04923 Regulation of lipolysis in adipocytes 7/179 77/7206 0.00288544520409 ko04720 Long-term potentiation 8/179 99/7206 0.0030972574259 ko04912 GnRH signaling pathway 9/179 122/7206 0.00322985506233 ko04020 Calcium signaling pathway 15/179 265/7206 0.0034982753494 ko05230 Central carbon metabolism in cancer 7/179 81/7206 0.00384045854017 ko04914 Progesterone-mediated oocyte maturation 8/179 104/7206 0.00419670791426 ko04213 Longevity regulating pathway - multiple species 7/179 86/7206 0.00535154092115 ko04918 Thyroid hormone synthesis 7/179 86/7206 0.00535154092115 ko00512 Mucin type O-glycan biosynthesis 4/179 29/7206 0.00538029199985 ko04921 Oxytocin signaling pathway 12/179 209/7206 0.00571468461444 ko04320 Dorso-ventral axis formation 4/179 31/7206 0.00685858805553 ko05031 Amphetamine addiction 7/179 91/7206 0.00727082309737 ko04970 Salivary secretion 7/179 95/7206 0.00914084337123 ko05030 Cocaine addiction 6/179 73/7206 0.00928765070217 ko04011 MAPK signaling pathway - yeast 5/179 53/7206 0.00979214581101 ko04971 Gastric acid secretion 7/179 98/7206 0.0107588735557 ko00564 Glycerophospholipid metabolism 7/179 99/7206 0.0113418226092 ko04144 Endocytosis 16/179 342/7206 0.0122642771114 ko04016 MAPK signaling pathway - plant 3/179 20/7206 0.0125886068941 ko05214 Glioma 6/179 79/7206 0.0134312363217 ko04745 Phototransduction - fly 4/179 38/7206 0.0140690818383 ko04922 Glucagon signaling pathway 8/179 128/7206 0.014122927977 ko04261 Adrenergic signaling in cardiomyocytes 11/179 205/7206 0.0182915391868 ko00561 Glycerolipid metabolism 5/179 63/7206 0.0196849440853 ko04924 Renin secretion 6/179 86/7206 0.019726108638 ko04972 Pancreatic secretion 7/179 111/7206 0.0202297049471 ko04022 cGMP-PKG signaling pathway 11/179 216/7206 0.0224943345417 ko05223 Non-small cell lung cancer 5/179 66/7206 0.0235944902065 ko00380 Tryptophan metabolism 4/179 50/7206 0.0349409573885 ko04010 MAPK signaling pathway 14/179 321/7206 0.0402885526543 ko04810 Regulation of actin cytoskeleton 12/179 264/7206 0.0404087029298 ko05142 Chagas disease (American trypanosomiasis) 7/179 130/7206 0.0427210558865 ko04930 Type II diabetes mellitus 4/179 54/7206 0.0444928755374 ko04740 Olfactory transduction 5/179 80/7206 0.0482687397718