ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1156	423/7206	1.29607146456e-56
ko04724	Glutamatergic synapse	87/1156	152/7206	9.23525690927e-32
ko05033	Nicotine addiction	47/1156	56/7206	3.44593083708e-29
ko05032	Morphine addiction	65/1156	110/7206	4.83379234864e-25
ko04713	Circadian entrainment	73/1156	136/7206	1.97498091178e-24
ko04728	Dopaminergic synapse	87/1156	185/7206	1.1992810835e-23
ko04727	GABAergic synapse	63/1156	110/7206	2.8410787823e-23
ko04721	Synaptic vesicle cycle	51/1156	80/7206	5.08364379882e-22
ko04725	Cholinergic synapse	74/1156	160/7206	1.00151203213e-19
ko04020	Calcium signaling pathway	101/1156	265/7206	8.28452090828e-19
ko04742	Taste transduction	40/1156	61/7206	3.49413816654e-18
ko04024	cAMP signaling pathway	103/1156	279/7206	4.67765803521e-18
ko04723	Retrograde endocannabinoid signaling	75/1156	175/7206	1.27920742974e-17
ko04921	Oxytocin signaling pathway	80/1156	209/7206	2.78681444002e-15
ko04726	Serotonergic synapse	59/1156	137/7206	3.18586742652e-14
ko04911	Insulin secretion	53/1156	117/7206	5.36339749676e-14
ko04744	Phototransduction	25/1156	36/7206	1.074035282e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1156	205/7206	4.99743644819e-12
ko05031	Amphetamine addiction	42/1156	91/7206	1.08876502451e-11
ko04970	Salivary secretion	43/1156	95/7206	1.38444200531e-11
ko04720	Long-term potentiation	44/1156	99/7206	1.71279631007e-11
ko03040	Spliceosome	1/1156	145/7206	3.19385615496e-10
ko04360	Axon guidance	71/1156	233/7206	2.86158627462e-08
ko04740	Olfactory transduction	33/1156	80/7206	5.60381354957e-08
ko05203	Viral carcinogenesis	15/1156	277/7206	5.95160707379e-08
ko05030	Cocaine addiction	31/1156	73/7206	6.34151255868e-08
ko04060	Cytokine-cytokine receptor interaction	7/1156	191/7206	6.96121025429e-08
ko04022	cGMP-PKG signaling pathway	66/1156	216/7206	7.62479678122e-08
ko04971	Gastric acid secretion	36/1156	98/7206	4.88163508678e-07
ko04925	Aldosterone synthesis and secretion	38/1156	105/7206	5.38917681876e-07
ko05322	Systemic lupus erythematosus	5/1156	151/7206	8.84267004598e-07
ko05168	Herpes simplex infection	8/1156	182/7206	1.08999528787e-06
ko04010	MAPK signaling pathway	85/1156	321/7206	1.10133830163e-06
ko04966	Collecting duct acid secretion	15/1156	26/7206	1.46801972982e-06
ko04924	Renin secretion	32/1156	86/7206	1.6924830134e-06
ko03013	RNA transport	7/1156	166/7206	2.81054197546e-06
ko05164	Influenza A	7/1156	167/7206	2.9213631876e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1156	74/7206	6.64424729985e-06
ko04141	Protein processing in endoplasmic reticulum	10/1156	184/7206	1.47416487108e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1156	79/7206	1.96300500528e-05
ko04070	Phosphatidylinositol signaling system	36/1156	112/7206	2.11330968426e-05
ko04514	Cell adhesion molecules (CAMs)	40/1156	130/7206	2.84464578918e-05
ko04120	Ubiquitin mediated proteolysis	6/1156	138/7206	3.04410152421e-05
ko04610	Complement and coagulation cascades	1/1156	79/7206	3.37400971097e-05
ko04621	NOD-like receptor signaling pathway	8/1156	157/7206	3.66711265942e-05
ko04540	Gap junction	39/1156	128/7206	4.30796937807e-05
ko04014	Ras signaling pathway	70/1156	279/7206	8.10007258892e-05
ko04745	Phototransduction - fly	16/1156	38/7206	0.000114566427646
ko05414	Dilated cardiomyopathy	34/1156	112/7206	0.000128928446818
ko04730	Long-term depression	26/1156	78/7206	0.000138449332255
ko05110	Vibrio cholerae infection	22/1156	63/7206	0.000200802882547
ko05169	Epstein-Barr virus infection	15/1156	206/7206	0.000224814906447
ko04260	Cardiac muscle contraction	30/1156	98/7206	0.000256268686103
ko04612	Antigen processing and presentation	2/1156	77/7206	0.000259437259388
ko03008	Ribosome biogenesis in eukaryotes	2/1156	79/7206	0.000274427020691
ko04972	Pancreatic secretion	33/1156	111/7206	0.000341204567212
ko04072	Phospholipase D signaling pathway	51/1156	197/7206	0.000349066135377
ko05140	Leishmaniasis	2/1156	75/7206	0.000385465553524
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1156	14/7206	0.000518331155374
ko04110	Cell cycle	9/1156	145/7206	0.000525896656402
ko04371	Apelin signaling pathway	46/1156	177/7206	0.000568536053981
ko04064	NF-kappa B signaling pathway	4/1156	96/7206	0.00061797810871
ko05205	Proteoglycans in cancer	24/1156	271/7206	0.000686150445393
ko05161	Hepatitis B	13/1156	173/7206	0.00107994973711
ko04146	Peroxisome	4/1156	89/7206	0.0012062838437
ko00480	Glutathione metabolism	1/1156	55/7206	0.00132766317021
ko04750	Inflammatory mediator regulation of TRP channels	33/1156	122/7206	0.00169946739665
ko04976	Bile secretion	24/1156	80/7206	0.00178666993136
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1156	59/7206	0.0019295877731
ko00590	Arachidonic acid metabolism	1/1156	52/7206	0.00198503279252
ko05162	Measles	8/1156	120/7206	0.00355045156065
ko04915	Estrogen signaling pathway	34/1156	131/7206	0.00359479497333
ko00240	Pyrimidine metabolism	7/1156	110/7206	0.00362154198527
ko04626	Plant-pathogen interaction	8/1156	18/7206	0.00414108665653
ko00330	Arginine and proline metabolism	2/1156	61/7206	0.00417312615394
ko04923	Regulation of lipolysis in adipocytes	22/1156	77/7206	0.0046288458841
ko00260	Glycine, serine and threonine metabolism	1/1156	48/7206	0.00462919170947
ko04657	IL-17 signaling pathway	5/1156	87/7206	0.0050608466094
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1156	100/7206	0.0054652306223
ko05321	Inflammatory bowel disease (IBD)	2/1156	56/7206	0.0057773061719
ko03022	Basal transcription factors	1/1156	44/7206	0.00671953968525
ko05144	Malaria	1/1156	45/7206	0.00682103641164
ko00071	Fatty acid degradation	1/1156	45/7206	0.00682103641164
ko03420	Nucleotide excision repair	1/1156	46/7206	0.00716480360854
ko04640	Hematopoietic cell lineage	3/1156	64/7206	0.00939953598219
ko05131	Shigellosis	5/1156	82/7206	0.00973790954355
ko03018	RNA degradation	5/1156	84/7206	0.0100479246901
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1156	182/7206	0.0103876821579
ko04015	Rap1 signaling pathway	60/1156	278/7206	0.0123431414791
ko04210	Apoptosis	17/1156	180/7206	0.0132271940413
ko04622	RIG-I-like receptor signaling pathway	3/1156	62/7206	0.0135854141575
ko04214	Apoptosis - fly	4/1156	72/7206	0.0141263826137
ko05206	MicroRNAs in cancer	17/1156	177/7206	0.0167346244851
ko04217	Necroptosis	17/1156	178/7206	0.0168637516466
ko05133	Pertussis	6/1156	87/7206	0.0177505026848
ko04964	Proximal tubule bicarbonate reclamation	10/1156	29/7206	0.0179149268449
ko00380	Tryptophan metabolism	2/1156	50/7206	0.0182681184627
ko05418	Fluid shear stress and atherosclerosis	17/1156	173/7206	0.0211117030526
ko05166	HTLV-I infection	33/1156	292/7206	0.022598932325
ko03410	Base excision repair	1/1156	38/7206	0.023459162145
ko04140	Autophagy - animal	16/1156	164/7206	0.0237818291972
ko04115	p53 signaling pathway	5/1156	74/7206	0.025327255763
ko00620	Pyruvate metabolism	2/1156	46/7206	0.0256869722182
ko00270	Cysteine and methionine metabolism	2/1156	47/7206	0.0260922975275
ko01524	Platinum drug resistance	5/1156	76/7206	0.0261407533502
ko05145	Toxoplasmosis	11/1156	126/7206	0.026514393732
ko04620	Toll-like receptor signaling pathway	8/1156	100/7206	0.0272047497259
ko04922	Glucagon signaling pathway	30/1156	128/7206	0.0279645858018
ko00562	Inositol phosphate metabolism	22/1156	89/7206	0.0293362650661
ko04630	Jak-STAT signaling pathway	12/1156	132/7206	0.0302780325715
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1156	92/7206	0.0305021553227
ko05231	Choline metabolism in cancer	31/1156	134/7206	0.0315930361722
ko00640	Propanoate metabolism	1/1156	34/7206	0.0334286447152
ko00860	Porphyrin and chlorophyll metabolism	1/1156	34/7206	0.0334286447152
ko00500	Starch and sucrose metabolism	1/1156	35/7206	0.0342499544562
ko00310	Lysine degradation	5/1156	73/7206	0.0353194148127
ko04658	Th1 and Th2 cell differentiation	8/1156	96/7206	0.035671143806
ko04330	Notch signaling pathway	4/1156	62/7206	0.0364806064824
ko04916	Melanogenesis	32/1156	142/7206	0.0375712974065
ko00280	Valine, leucine and isoleucine degradation	3/1156	54/7206	0.038277434221
ko04350	TGF-beta signaling pathway	9/1156	103/7206	0.0419955467919
ko04668	TNF signaling pathway	11/1156	120/7206	0.0436040501032
ko04270	Vascular smooth muscle contraction	34/1156	154/7206	0.0452869963035
ko04912	GnRH signaling pathway	28/1156	122/7206	0.045470171493
ko03015	mRNA surveillance pathway	8/1156	93/7206	0.0468249762717
ko05215	Prostate cancer	10/1156	111/7206	0.0492195987635
ko04136	Autophagy - other	1/1156	31/7206	0.0495505084737