ko pathway ratio_in_study ratio_in_pop p_value ko04710 Circadian rhythm 15/681 43/7206 4.47750591925e-06 ko04020 Calcium signaling pathway 48/681 265/7206 8.18221364278e-06 ko04070 Phosphatidylinositol signaling system 26/681 112/7206 1.11555018513e-05 ko03010 Ribosome 1/681 129/7206 5.57324903216e-05 ko03040 Spliceosome 2/681 145/7206 0.000135773064395 ko04921 Oxytocin signaling pathway 37/681 209/7206 0.000158650761633 ko04060 Cytokine-cytokine receptor interaction 34/681 191/7206 0.000236966758698 ko00120 Primary bile acid biosynthesis 8/681 20/7206 0.000274308024607 ko04650 Natural killer cell mediated cytotoxicity 21/681 97/7206 0.000283369909951 ko04022 cGMP-PKG signaling pathway 37/681 216/7206 0.000328909851933 ko04922 Glucagon signaling pathway 25/681 128/7206 0.000362799830866 ko04713 Circadian entrainment 26/681 136/7206 0.000495021941097 ko04724 Glutamatergic synapse 28/681 152/7206 0.000600285497879 ko03013 RNA transport 4/681 166/7206 0.000643052254833 ko04110 Cell cycle 3/681 145/7206 0.000778029166682 ko04925 Aldosterone synthesis and secretion 21/681 105/7206 0.00102066926923 ko00051 Fructose and mannose metabolism 11/681 42/7206 0.00137998216073 ko05322 Systemic lupus erythematosus 4/681 151/7206 0.00173581879535 ko04080 Neuroactive ligand-receptor interaction 59/681 423/7206 0.00194953687952 ko04725 Cholinergic synapse 27/681 160/7206 0.00245322462927 ko04726 Serotonergic synapse 24/681 137/7206 0.00275849750447 ko04072 Phospholipase D signaling pathway 31/681 197/7206 0.0041845107677 ko04270 Vascular smooth muscle contraction 25/681 154/7206 0.00738316952365 ko04970 Salivary secretion 17/681 95/7206 0.0117104296068 ko04137 Mitophagy - animal 15/681 82/7206 0.0117661314497 ko00680 Methane metabolism 8/681 34/7206 0.0120632522655 ko00010 Glycolysis / Gluconeogenesis 14/681 74/7206 0.014026243298 ko04720 Long-term potentiation 17/681 99/7206 0.0140556312782 ko01230 Biosynthesis of amino acids 15/681 85/7206 0.0146323523981 ko05203 Viral carcinogenesis 15/681 277/7206 0.0158919782892 ko04911 Insulin secretion 19/681 117/7206 0.0163247996065 ko05031 Amphetamine addiction 16/681 91/7206 0.0168504005807 ko04640 Hematopoietic cell lineage 12/681 64/7206 0.0170811947534 ko04730 Long-term depression 14/681 78/7206 0.0173679133297 ko04672 Intestinal immune network for IgA production 8/681 37/7206 0.0199564109601 ko04014 Ras signaling pathway 38/681 279/7206 0.0210201091916 ko05230 Central carbon metabolism in cancer 14/681 81/7206 0.0214750767666 ko04745 Phototransduction - fly 8/681 38/7206 0.0232553947878 ko04380 Osteoclast differentiation 21/681 134/7206 0.0237082179714 ko04662 B cell receptor signaling pathway 15/681 88/7206 0.0251153594275 ko00592 alpha-Linolenic acid metabolism 5/681 19/7206 0.0281844791898 ko04711 Circadian rhythm - fly 4/681 13/7206 0.0282754142113 ko04611 Platelet activation 24/681 163/7206 0.02888614775 ko05130 Pathogenic Escherichia coli infection 2/681 77/7206 0.0312594659187 ko00350 Tyrosine metabolism 7/681 33/7206 0.031641296319 ko03015 mRNA surveillance pathway 3/681 93/7206 0.0323492499799 ko00564 Glycerophospholipid metabolism 16/681 99/7206 0.035163811778 ko05321 Inflammatory bowel disease (IBD) 10/681 56/7206 0.0388151634614 ko04924 Renin secretion 14/681 86/7206 0.0392986196679 ko05032 Morphine addiction 17/681 110/7206 0.0460337575823 ko00561 Glycerolipid metabolism 11/681 63/7206 0.0466066789339 ko00290 Valine, leucine and isoleucine biosynthesis 2/681 4/7206 0.04702748729 ko05224 Breast cancer 9/681 174/7206 0.0490027640076 ko00380 Tryptophan metabolism 9/681 50/7206 0.0492022103926 ko04610 Complement and coagulation cascades 13/681 79/7206 0.0492416549743