ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1288	423/7206	1.03499536755e-54
ko04724	Glutamatergic synapse	92/1288	152/7206	2.27585482135e-32
ko05033	Nicotine addiction	48/1288	56/7206	1.97636964372e-28
ko05032	Morphine addiction	70/1288	110/7206	9.4545940372e-27
ko04713	Circadian entrainment	79/1288	136/7206	3.17802063686e-26
ko04727	GABAergic synapse	66/1288	110/7206	3.51008552867e-23
ko04721	Synaptic vesicle cycle	52/1288	80/7206	8.82600401905e-21
ko04728	Dopaminergic synapse	86/1288	185/7206	1.03989281451e-19
ko04725	Cholinergic synapse	78/1288	160/7206	1.59044646233e-19
ko04024	cAMP signaling pathway	110/1288	279/7206	4.59680750675e-18
ko04020	Calcium signaling pathway	106/1288	265/7206	5.56791297797e-18
ko04723	Retrograde endocannabinoid signaling	79/1288	175/7206	2.9507252393e-17
ko04911	Insulin secretion	59/1288	117/7206	6.4213926438e-16
ko04742	Taste transduction	39/1288	61/7206	1.56637363903e-15
ko04726	Serotonergic synapse	63/1288	137/7206	1.82238580586e-14
ko04744	Phototransduction	27/1288	36/7206	9.13784708297e-14
ko04921	Oxytocin signaling pathway	82/1288	209/7206	1.44223402421e-13
ko04970	Salivary secretion	46/1288	95/7206	6.89583234488e-12
ko04740	Olfactory transduction	41/1288	80/7206	9.5011547502e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1288	205/7206	3.20813796186e-11
ko04720	Long-term potentiation	46/1288	99/7206	4.20845045739e-11
ko05031	Amphetamine addiction	43/1288	91/7206	9.24928440437e-11
ko03040	Spliceosome	2/1288	145/7206	2.28379867666e-10
ko04360	Axon guidance	78/1288	233/7206	5.30947570451e-09
ko05203	Viral carcinogenesis	17/1288	277/7206	8.79012848938e-09
ko04022	cGMP-PKG signaling pathway	73/1288	216/7206	1.18946374307e-08
ko04925	Aldosterone synthesis and secretion	43/1288	105/7206	2.24405048551e-08
ko05168	Herpes simplex infection	8/1288	182/7206	6.5686734368e-08
ko03013	RNA transport	7/1288	166/7206	1.66188987607e-07
ko04540	Gap junction	47/1288	128/7206	2.94669430964e-07
ko04971	Gastric acid secretion	39/1288	98/7206	3.23472435955e-07
ko04060	Cytokine-cytokine receptor interaction	11/1288	191/7206	1.1660847442e-06
ko05030	Cocaine addiction	31/1288	73/7206	1.30749791139e-06
ko05322	Systemic lupus erythematosus	7/1288	151/7206	1.54207744413e-06
ko04924	Renin secretion	34/1288	86/7206	2.49086742269e-06
ko04621	NOD-like receptor signaling pathway	8/1288	157/7206	2.54898024467e-06
ko04966	Collecting duct acid secretion	15/1288	26/7206	6.00432108165e-06
ko04514	Cell adhesion molecules (CAMs)	44/1288	130/7206	1.29348019783e-05
ko04972	Pancreatic secretion	39/1288	111/7206	1.37551354975e-05
ko04010	MAPK signaling pathway	88/1288	321/7206	1.39015686444e-05
ko04120	Ubiquitin mediated proteolysis	7/1288	138/7206	1.4195580115e-05
ko04730	Long-term depression	30/1288	78/7206	1.66991924459e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1288	74/7206	1.94358085626e-05
ko04260	Cardiac muscle contraction	35/1288	98/7206	2.42924779698e-05
ko04976	Bile secretion	30/1288	80/7206	2.59079236903e-05
ko04141	Protein processing in endoplasmic reticulum	13/1288	184/7206	3.42009625337e-05
ko05164	Influenza A	11/1288	167/7206	3.44610651549e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1288	79/7206	4.44838835643e-05
ko04923	Regulation of lipolysis in adipocytes	28/1288	77/7206	0.00012056619728
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1288	79/7206	0.000164948647925
ko04110	Cell cycle	10/1288	145/7206	0.000172411571711
ko04014	Ras signaling pathway	74/1288	279/7206	0.000232511822976
ko04146	Peroxisome	4/1288	89/7206	0.000246680470286
ko05414	Dilated cardiomyopathy	36/1288	112/7206	0.000248566748335
ko05169	Epstein-Barr virus infection	18/1288	206/7206	0.000285783266589
ko04610	Complement and coagulation cascades	3/1288	79/7206	0.000300021761629
ko04750	Inflammatory mediator regulation of TRP channels	38/1288	122/7206	0.000301888896097
ko05110	Vibrio cholerae infection	23/1288	63/7206	0.00038354751707
ko04064	NF-kappa B signaling pathway	5/1288	96/7206	0.000403744071573
ko04745	Phototransduction - fly	16/1288	38/7206	0.000419338716622
ko04072	Phospholipase D signaling pathway	55/1288	197/7206	0.000437675795151
ko00240	Pyrimidine metabolism	7/1288	110/7206	0.000632885212327
ko05205	Proteoglycans in cancer	28/1288	271/7206	0.000645404922631
ko05162	Measles	8/1288	120/7206	0.000654836773232
ko04371	Apelin signaling pathway	50/1288	177/7206	0.000655874891962
ko04070	Phosphatidylinositol signaling system	35/1288	112/7206	0.000662639779961
ko05140	Leishmaniasis	3/1288	75/7206	0.000663560375681
ko04964	Proximal tubule bicarbonate reclamation	13/1288	29/7206	0.000707090730785
ko04214	Apoptosis - fly	3/1288	72/7206	0.000944614580729
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1288	59/7206	0.000981648709194
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1288	14/7206	0.00110167122039
ko04612	Antigen processing and presentation	4/1288	77/7206	0.00154448885109
ko04657	IL-17 signaling pathway	5/1288	87/7206	0.00167768557512
ko04915	Estrogen signaling pathway	38/1288	131/7206	0.00169755215057
ko05161	Hepatitis B	16/1288	173/7206	0.00175566848649
ko04270	Vascular smooth muscle contraction	43/1288	154/7206	0.00189257015536
ko05321	Inflammatory bowel disease (IBD)	2/1288	56/7206	0.0024401905976
ko03022	Basal transcription factors	1/1288	44/7206	0.00270385998811
ko00071	Fatty acid degradation	1/1288	45/7206	0.00272857531945
ko03420	Nucleotide excision repair	1/1288	46/7206	0.00288727061988
ko00310	Lysine degradation	4/1288	73/7206	0.00315786011946
ko05131	Shigellosis	5/1288	82/7206	0.00332293850177
ko00280	Valine, leucine and isoleucine degradation	2/1288	54/7206	0.00363902945706
ko04622	RIG-I-like receptor signaling pathway	3/1288	62/7206	0.00416656912639
ko05133	Pertussis	6/1288	87/7206	0.00460117650326
ko00590	Arachidonic acid metabolism	2/1288	52/7206	0.00543681347533
ko04630	Jak-STAT signaling pathway	12/1288	132/7206	0.005761163563
ko00330	Arginine and proline metabolism	3/1288	61/7206	0.00627510571237
ko01524	Platinum drug resistance	5/1288	76/7206	0.00646168555387
ko00380	Tryptophan metabolism	2/1288	50/7206	0.00813173919714
ko04626	Plant-pathogen interaction	8/1288	18/7206	0.00817892191904
ko05418	Fluid shear stress and atherosclerosis	18/1288	173/7206	0.00867814134214
ko04115	p53 signaling pathway	5/1288	74/7206	0.00901171394726
ko03018	RNA degradation	6/1288	84/7206	0.00908651216937
ko04217	Necroptosis	19/1288	178/7206	0.00975813066208
ko04658	Th1 and Th2 cell differentiation	8/1288	96/7206	0.0106824238313
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1288	100/7206	0.0118653284771
ko00480	Glutathione metabolism	3/1288	55/7206	0.0124182271815
ko05145	Toxoplasmosis	12/1288	126/7206	0.0131620415004
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1288	182/7206	0.0138857117232
ko04922	Glucagon signaling pathway	34/1288	128/7206	0.0139437105688
ko03320	PPAR signaling pathway	5/1288	69/7206	0.0173082227325
ko04620	Toll-like receptor signaling pathway	9/1288	100/7206	0.0175210921361
ko04330	Notch signaling pathway	4/1288	62/7206	0.0182556852598
ko05166	HTLV-I infection	37/1288	292/7206	0.0190143948207
ko00860	Porphyrin and chlorophyll metabolism	1/1288	34/7206	0.0218439888748
ko04668	TNF signaling pathway	12/1288	120/7206	0.0219639253795
ko04918	Thyroid hormone synthesis	24/1288	86/7206	0.0222835948934
ko04912	GnRH signaling pathway	32/1288	122/7206	0.0226815429812
ko05215	Prostate cancer	11/1288	111/7206	0.0245362615291
ko04015	Rap1 signaling pathway	64/1288	278/7206	0.025308612573
ko05222	Small cell lung cancer	8/1288	89/7206	0.0255120024242
ko04916	Melanogenesis	36/1288	142/7206	0.0261754669079
ko04210	Apoptosis	21/1288	180/7206	0.0296403229744
ko04930	Type II diabetes mellitus	16/1288	54/7206	0.0312661384612
ko00562	Inositol phosphate metabolism	24/1288	89/7206	0.0353605364857
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1288	40/7206	0.0357722679139
ko00260	Glycine, serine and threonine metabolism	3/1288	48/7206	0.0358412439671
ko05219	Bladder cancer	3/1288	48/7206	0.0358412439671
ko04973	Carbohydrate digestion and absorption	13/1288	42/7206	0.0402949472821
ko04113	Meiosis - yeast	6/1288	70/7206	0.0409813348763
ko04213	Longevity regulating pathway - multiple species	23/1288	86/7206	0.0458365376884
ko05132	Salmonella infection	10/1288	98/7206	0.0461964696384
ko05320	Autoimmune thyroid disease	1/1288	29/7206	0.0481901965107