ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 109/590 423/7206 1.11766385991e-29 ko05033 Nicotine addiction 36/590 56/7206 4.51078851916e-26 ko04721 Synaptic vesicle cycle 41/590 80/7206 3.73874887452e-24 ko04724 Glutamatergic synapse 56/590 152/7206 1.36086415623e-23 ko05032 Morphine addiction 42/590 110/7206 1.29979701148e-18 ko04727 GABAergic synapse 41/590 110/7206 9.49490249773e-18 ko04723 Retrograde endocannabinoid signaling 52/590 175/7206 3.13820884615e-17 ko04728 Dopaminergic synapse 52/590 185/7206 4.320582701e-16 ko04713 Circadian entrainment 41/590 136/7206 4.73359029493e-14 ko04725 Cholinergic synapse 42/590 160/7206 4.07797783008e-12 ko04024 cAMP signaling pathway 57/590 279/7206 6.93411924079e-11 ko04726 Serotonergic synapse 35/590 137/7206 5.97219077573e-10 ko04966 Collecting duct acid secretion 13/590 26/7206 2.50481528948e-08 ko04911 Insulin secretion 29/590 117/7206 3.80079494567e-08 ko05030 Cocaine addiction 22/590 73/7206 3.98342300842e-08 ko05031 Amphetamine addiction 23/590 91/7206 6.80640980046e-07 ko04742 Taste transduction 18/590 61/7206 9.78330279826e-07 ko04921 Oxytocin signaling pathway 38/590 209/7206 2.16588859755e-06 ko04261 Adrenergic signaling in cardiomyocytes 37/590 205/7206 3.48564278846e-06 ko04514 Cell adhesion molecules (CAMs) 27/590 130/7206 4.71758250357e-06 ko05110 Vibrio cholerae infection 17/590 63/7206 7.5621831036e-06 ko04010 MAPK signaling pathway 50/590 321/7206 8.68710168176e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 18/590 74/7206 1.97053071905e-05 ko04720 Long-term potentiation 21/590 99/7206 3.84929772704e-05 ko04730 Long-term depression 18/590 78/7206 4.2252689425e-05 ko04970 Salivary secretion 20/590 95/7206 6.56502743755e-05 ko03040 Spliceosome 1/590 145/7206 9.03106665989e-05 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/590 92/7206 0.000130433268743 ko05205 Proteoglycans in cancer 7/590 271/7206 0.00016309494204 ko04120 Ubiquitin mediated proteolysis 1/590 138/7206 0.000208550685215 ko04260 Cardiac muscle contraction 19/590 98/7206 0.000310147629005 ko04020 Calcium signaling pathway 38/590 265/7206 0.000549782115736 ko04972 Pancreatic secretion 20/590 111/7206 0.000663782849487 ko05203 Viral carcinogenesis 9/590 277/7206 0.00108166725803 ko05323 Rheumatoid arthritis 17/590 89/7206 0.00123314887087 ko05168 Herpes simplex infection 4/590 182/7206 0.001367940093 ko00190 Oxidative phosphorylation 21/590 127/7206 0.00161168305859 ko04060 Cytokine-cytokine receptor interaction 5/590 191/7206 0.00195364196306 ko04744 Phototransduction 9/590 36/7206 0.00196000723954 ko04145 Phagosome 25/590 162/7206 0.00196281306815 ko05322 Systemic lupus erythematosus 3/590 151/7206 0.00231780429965 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/590 59/7206 0.00254341484546 ko04360 Axon guidance 32/590 233/7206 0.00330040584964 ko04014 Ras signaling pathway 37/590 279/7206 0.00347952609153 ko04510 Focal adhesion 8/590 240/7206 0.00369798027773 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/590 14/7206 0.00387959101041 ko05162 Measles 2/590 120/7206 0.00390743656076 ko04540 Gap junction 20/590 128/7206 0.00483999368935 ko04022 cGMP-PKG signaling pathway 29/590 216/7206 0.00760979046094 ko03013 RNA transport 5/590 166/7206 0.00948723048804 ko05164 Influenza A 5/590 167/7206 0.00952550349382 ko04930 Type II diabetes mellitus 10/590 54/7206 0.0111450559867 ko05010 Alzheimer's disease 27/590 202/7206 0.0124818075075 ko04626 Plant-pathogen interaction 5/590 18/7206 0.0126246520294 ko04140 Autophagy - animal 5/590 164/7206 0.0132274952502 ko05034 Alcoholism 30/590 238/7206 0.0157515346926 ko04072 Phospholipase D signaling pathway 26/590 197/7206 0.0166210203311 ko03008 Ribosome biogenesis in eukaryotes 1/590 79/7206 0.0203922333206 ko04962 Vasopressin-regulated water reabsorption 10/590 58/7206 0.0250230942744 ko04141 Protein processing in endoplasmic reticulum 7/590 184/7206 0.0280503024207 ko04214 Apoptosis - fly 1/590 72/7206 0.0286571936744 ko05166 HTLV-I infection 14/590 292/7206 0.0289241809489 ko04925 Aldosterone synthesis and secretion 15/590 105/7206 0.0298782314077 ko04146 Peroxisome 2/590 89/7206 0.0322664832308 ko00240 Pyrimidine metabolism 3/590 110/7206 0.0336412295091 ko04915 Estrogen signaling pathway 18/590 131/7206 0.0342560534595 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/590 79/7206 0.0353018512171 ko04971 Gastric acid secretion 14/590 98/7206 0.0384555508525 ko05169 Epstein-Barr virus infection 9/590 206/7206 0.0390806061594 ko04621 NOD-like receptor signaling pathway 6/590 157/7206 0.0393479957851 ko05161 Hepatitis B 7/590 173/7206 0.0478727843939