ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	144/845	423/7206	3.64181278125e-36
ko04721	Synaptic vesicle cycle	52/845	80/7206	1.10350602123e-29
ko05033	Nicotine addiction	43/845	56/7206	1.50773131831e-29
ko04724	Glutamatergic synapse	72/845	152/7206	2.05262210693e-28
ko04727	GABAergic synapse	54/845	110/7206	1.78751672302e-22
ko05032	Morphine addiction	53/845	110/7206	1.35560637938e-21
ko04723	Retrograde endocannabinoid signaling	65/845	175/7206	9.71103131361e-19
ko04713	Circadian entrainment	55/845	136/7206	5.67175552497e-18
ko04728	Dopaminergic synapse	66/845	185/7206	6.02379371475e-18
ko04725	Cholinergic synapse	59/845	160/7206	6.22604778333e-17
ko04742	Taste transduction	30/845	61/7206	4.72395177415e-13
ko04024	cAMP signaling pathway	74/845	279/7206	3.53611634884e-12
ko04911	Insulin secretion	42/845	117/7206	5.99631041751e-12
ko04726	Serotonergic synapse	44/845	137/7206	1.33602843006e-10
ko04921	Oxytocin signaling pathway	57/845	209/7206	4.50882178749e-10
ko05031	Amphetamine addiction	33/845	91/7206	8.46510236903e-10
ko04261	Adrenergic signaling in cardiomyocytes	53/845	205/7206	1.38962132591e-08
ko04020	Calcium signaling pathway	63/845	265/7206	2.50989752685e-08
ko04720	Long-term potentiation	32/845	99/7206	3.85098437774e-08
ko04744	Phototransduction	17/845	36/7206	1.25952398135e-07
ko04966	Collecting duct acid secretion	14/845	26/7206	2.08174104165e-07
ko05030	Cocaine addiction	25/845	73/7206	3.44686302521e-07
ko03040	Spliceosome	1/845	145/7206	3.53069235203e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	24/845	74/7206	1.817371337e-06
ko05168	Herpes simplex infection	4/845	182/7206	3.40784830352e-06
ko04260	Cardiac muscle contraction	28/845	98/7206	4.38223630311e-06
ko05110	Vibrio cholerae infection	21/845	63/7206	4.89990470148e-06
ko04514	Cell adhesion molecules (CAMs)	34/845	130/7206	5.28740509848e-06
ko05203	Viral carcinogenesis	11/845	277/7206	6.04957054148e-06
ko04970	Salivary secretion	27/845	95/7206	7.22669489506e-06
ko04010	MAPK signaling pathway	63/845	321/7206	2.61055576557e-05
ko04626	Plant-pathogen interaction	9/845	18/7206	7.29959681292e-05
ko04120	Ubiquitin mediated proteolysis	3/845	138/7206	7.53151262154e-05
ko03013	RNA transport	5/845	166/7206	7.66651094209e-05
ko05164	Influenza A	5/845	167/7206	7.69839110677e-05
ko05162	Measles	2/845	120/7206	7.72872726009e-05
ko04925	Aldosterone synthesis and secretion	27/845	105/7206	8.02924221315e-05
ko04971	Gastric acid secretion	25/845	98/7206	0.000176538583754
ko05205	Proteoglycans in cancer	14/845	271/7206	0.000235075296747
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/845	79/7206	0.000260549747798
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/845	59/7206	0.000295694347941
ko04060	Cytokine-cytokine receptor interaction	8/845	191/7206	0.000363955989202
ko00190	Oxidative phosphorylation	29/845	127/7206	0.000384840795586
ko04740	Olfactory transduction	20/845	80/7206	0.000748675426128
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/845	92/7206	0.000878150095226
ko03008	Ribosome biogenesis in eukaryotes	1/845	79/7206	0.00116947158428
ko05322	Systemic lupus erythematosus	6/845	151/7206	0.00125146950313
ko05161	Hepatitis B	8/845	173/7206	0.0017251375598
ko04730	Long-term depression	19/845	78/7206	0.0019763805511
ko04540	Gap junction	27/845	128/7206	0.00203948413341
ko04110	Cell cycle	6/845	145/7206	0.00241120961264
ko04972	Pancreatic secretion	24/845	111/7206	0.00256956493895
ko05010	Alzheimer's disease	38/845	202/7206	0.00262345531554
ko05169	Epstein-Barr virus infection	11/845	206/7206	0.00276814735085
ko04510	Focal adhesion	14/845	240/7206	0.0028792232475
ko04962	Vasopressin-regulated water reabsorption	15/845	58/7206	0.00291615447355
ko04371	Apelin signaling pathway	34/845	177/7206	0.00299100306155
ko04014	Ras signaling pathway	49/845	279/7206	0.00315434427597
ko04360	Axon guidance	42/845	233/7206	0.00366960355102
ko05034	Alcoholism	43/845	238/7206	0.00385815627061
ko04141	Protein processing in endoplasmic reticulum	10/845	184/7206	0.00506630697954
ko04022	cGMP-PKG signaling pathway	39/845	216/7206	0.00508586020087
ko04064	NF-kappa B signaling pathway	3/845	96/7206	0.00577342226777
ko04915	Estrogen signaling pathway	26/845	131/7206	0.00586839222301
ko04924	Renin secretion	19/845	86/7206	0.00598939364842
ko04630	Jak-STAT signaling pathway	6/845	132/7206	0.00608343293115
ko05166	HTLV-I infection	20/845	292/7206	0.00685125454175
ko05414	Dilated cardiomyopathy	23/845	112/7206	0.00693440371945
ko05323	Rheumatoid arthritis	19/845	89/7206	0.00764849891004
ko04621	NOD-like receptor signaling pathway	8/845	157/7206	0.00782919636641
ko00330	Arginine and proline metabolism	1/845	61/7206	0.00816188487532
ko00310	Lysine degradation	2/845	73/7206	0.0100356517636
ko04745	Phototransduction - fly	10/845	38/7206	0.0102295728506
ko05140	Leishmaniasis	2/845	75/7206	0.0102296799973
ko01524	Platinum drug resistance	2/845	76/7206	0.0105312535551
ko04146	Peroxisome	3/845	89/7206	0.0115297948737
ko04072	Phospholipase D signaling pathway	35/845	197/7206	0.012863935573
ko04976	Bile secretion	17/845	80/7206	0.0131782795563
ko04214	Apoptosis - fly	2/845	72/7206	0.0148677926687
ko04964	Proximal tubule bicarbonate reclamation	8/845	29/7206	0.0156310096973
ko00280	Valine, leucine and isoleucine degradation	1/845	54/7206	0.017688930177
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/845	14/7206	0.0177117279891
ko00520	Amino sugar and nucleotide sugar metabolism	1/845	55/7206	0.0181132420244
ko00480	Glutathione metabolism	1/845	55/7206	0.0181132420244
ko04210	Apoptosis	11/845	180/7206	0.0181390958965
ko04750	Inflammatory mediator regulation of TRP channels	23/845	122/7206	0.0218114389539
ko04611	Platelet activation	10/845	163/7206	0.0256692396657
ko00590	Arachidonic acid metabolism	1/845	52/7206	0.027023252263
ko05410	Hypertrophic cardiomyopathy (HCM)	19/845	100/7206	0.0282355020978
ko04330	Notch signaling pathway	2/845	62/7206	0.0293783827471
ko04640	Hematopoietic cell lineage	2/845	64/7206	0.029678179345
ko04930	Type II diabetes mellitus	12/845	54/7206	0.0298124748217
ko05222	Small cell lung cancer	4/845	89/7206	0.0301065780092
ko04612	Antigen processing and presentation	3/845	77/7206	0.0307499810824
ko04145	Phagosome	28/845	162/7206	0.0346976036046
ko00240	Pyrimidine metabolism	6/845	110/7206	0.0362382679136
ko05215	Prostate cancer	6/845	111/7206	0.0363582069903
ko03420	Nucleotide excision repair	1/845	46/7206	0.0377628357579
ko05219	Bladder cancer	1/845	48/7206	0.0389174375956
ko05146	Amoebiasis	5/845	99/7206	0.0392499399592
ko05220	Chronic myeloid leukemia	4/845	85/7206	0.0410425207325
ko04115	p53 signaling pathway	3/845	74/7206	0.0431404817835
ko04218	Cellular senescence	12/845	177/7206	0.043201848026
ko04668	TNF signaling pathway	7/845	120/7206	0.0441155247227
ko01521	EGFR tyrosine kinase inhibitor resistance	6/845	106/7206	0.0480716586241