ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/965	423/7206	1.10561548757e-52
ko05033	Nicotine addiction	48/965	56/7206	2.12000095406e-34
ko04724	Glutamatergic synapse	79/965	152/7206	1.33456397213e-30
ko05032	Morphine addiction	60/965	110/7206	6.3823144347e-25
ko04727	GABAergic synapse	59/965	110/7206	5.15748105549e-24
ko04723	Retrograde endocannabinoid signaling	72/965	175/7206	2.7900089511e-20
ko04728	Dopaminergic synapse	74/965	185/7206	5.86424733606e-20
ko04713	Circadian entrainment	61/965	136/7206	1.32668268503e-19
ko04721	Synaptic vesicle cycle	44/965	80/7206	9.15896537443e-19
ko04024	cAMP signaling pathway	91/965	279/7206	2.66341113962e-17
ko04725	Cholinergic synapse	63/965	160/7206	9.62341326431e-17
ko04742	Taste transduction	33/965	61/7206	4.17333585162e-14
ko04020	Calcium signaling pathway	81/965	265/7206	1.07481307889e-13
ko04911	Insulin secretion	47/965	117/7206	3.55726596284e-13
ko04726	Serotonergic synapse	51/965	137/7206	1.17543320931e-12
ko04261	Adrenergic signaling in cardiomyocytes	63/965	205/7206	5.04382420778e-11
ko04921	Oxytocin signaling pathway	63/965	209/7206	1.49481529996e-10
ko04744	Phototransduction	21/965	36/7206	2.85034529838e-10
ko05031	Amphetamine addiction	35/965	91/7206	1.55115918419e-09
ko04720	Long-term potentiation	36/965	99/7206	5.3840026587e-09
ko03040	Spliceosome	1/965	145/7206	3.79419960357e-08
ko05030	Cocaine addiction	28/965	73/7206	7.27732634701e-08
ko05203	Viral carcinogenesis	11/965	277/7206	1.86389918124e-07
ko04970	Salivary secretion	32/965	95/7206	2.98184545645e-07
ko04060	Cytokine-cytokine receptor interaction	5/965	191/7206	4.07942164051e-07
ko04925	Aldosterone synthesis and secretion	33/965	105/7206	1.4311477042e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/965	74/7206	1.55204333891e-06
ko04010	MAPK signaling pathway	73/965	321/7206	3.11953216013e-06
ko05168	Herpes simplex infection	6/965	182/7206	4.53211361768e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/965	79/7206	6.24711425063e-06
ko04022	cGMP-PKG signaling pathway	53/965	216/7206	6.37698448687e-06
ko04072	Phospholipase D signaling pathway	48/965	197/7206	2.66360693767e-05
ko04260	Cardiac muscle contraction	29/965	98/7206	3.04975847097e-05
ko04971	Gastric acid secretion	29/965	98/7206	3.04975847097e-05
ko04514	Cell adhesion molecules (CAMs)	35/965	130/7206	3.72764369776e-05
ko05322	Systemic lupus erythematosus	5/965	151/7206	4.9018733651e-05
ko04972	Pancreatic secretion	31/965	111/7206	5.29890859092e-05
ko05414	Dilated cardiomyopathy	31/965	112/7206	5.83333702403e-05
ko04141	Protein processing in endoplasmic reticulum	8/965	184/7206	6.40725965615e-05
ko04621	NOD-like receptor signaling pathway	6/965	157/7206	7.65921581606e-05
ko03013	RNA transport	7/965	166/7206	0.00011747172227
ko05164	Influenza A	7/965	167/7206	0.00011915518147
ko04966	Collecting duct acid secretion	11/965	26/7206	0.000264992284226
ko04360	Axon guidance	51/965	233/7206	0.000269859672144
ko04612	Antigen processing and presentation	1/965	77/7206	0.000308131866579
ko04610	Complement and coagulation cascades	1/965	79/7206	0.000326239856064
ko05205	Proteoglycans in cancer	18/965	271/7206	0.00050136455035
ko05169	Epstein-Barr virus infection	12/965	206/7206	0.000561537894642
ko04350	TGF-beta signaling pathway	3/965	103/7206	0.000624903852952
ko04740	Olfactory transduction	22/965	80/7206	0.00072307402756
ko04976	Bile secretion	22/965	80/7206	0.00072307402756
ko04070	Phosphatidylinositol signaling system	28/965	112/7206	0.00106128928573
ko04915	Estrogen signaling pathway	31/965	131/7206	0.00111309745656
ko04110	Cell cycle	7/965	145/7206	0.00118754062997
ko05110	Vibrio cholerae infection	18/965	63/7206	0.00124015575364
ko04064	NF-kappa B signaling pathway	3/965	96/7206	0.00126013466107
ko05161	Hepatitis B	10/965	173/7206	0.00148733417312
ko04540	Gap junction	30/965	128/7206	0.00157068612235
ko04120	Ubiquitin mediated proteolysis	7/965	138/7206	0.00221040416115
ko03008	Ribosome biogenesis in eukaryotes	2/965	79/7206	0.00223862363459
ko04217	Necroptosis	11/965	178/7206	0.00250971125622
ko04146	Peroxisome	3/965	89/7206	0.00255194649662
ko05140	Leishmaniasis	2/965	75/7206	0.00314834478483
ko04730	Long-term depression	20/965	78/7206	0.00371381351209
ko04630	Jak-STAT signaling pathway	7/965	132/7206	0.00413911724585
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/965	59/7206	0.00577107320437
ko04924	Renin secretion	21/965	86/7206	0.00586659825809
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/965	14/7206	0.0065423616516
ko04750	Inflammatory mediator regulation of TRP channels	27/965	122/7206	0.00693328663612
ko05410	Hypertrophic cardiomyopathy (HCM)	23/965	100/7206	0.0073711501505
ko04510	Focal adhesion	19/965	240/7206	0.00911501624684
ko04640	Hematopoietic cell lineage	2/965	64/7206	0.00940363457462
ko05162	Measles	7/965	120/7206	0.0100982973312
ko04140	Autophagy - animal	11/965	164/7206	0.0101515721194
ko00240	Pyrimidine metabolism	6/965	110/7206	0.0105591763567
ko05215	Prostate cancer	6/965	111/7206	0.0106812027608
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/965	182/7206	0.010774714464
ko04964	Proximal tubule bicarbonate reclamation	9/965	29/7206	0.0109193914194
ko00590	Arachidonic acid metabolism	1/965	52/7206	0.0119554734925
ko04745	Phototransduction - fly	11/965	38/7206	0.0132071499878
ko04330	Notch signaling pathway	2/965	62/7206	0.0136411547098
ko04930	Type II diabetes mellitus	14/965	54/7206	0.0137475191871
ko04214	Apoptosis - fly	3/965	72/7206	0.0147214364828
ko00310	Lysine degradation	3/965	73/7206	0.01472180444
ko03018	RNA degradation	4/965	84/7206	0.015030087483
ko03420	Nucleotide excision repair	1/965	46/7206	0.0166055025439
ko05145	Toxoplasmosis	8/965	126/7206	0.0168839046427
ko05219	Bladder cancer	1/965	48/7206	0.0169881980938
ko03022	Basal transcription factors	1/965	44/7206	0.0245704135666
ko05144	Malaria	1/965	45/7206	0.0251387027651
ko00071	Fatty acid degradation	1/965	45/7206	0.0251387027651
ko04210	Apoptosis	14/965	180/7206	0.0259085171552
ko05222	Small cell lung cancer	5/965	89/7206	0.0275310992176
ko00480	Glutathione metabolism	2/965	55/7206	0.0279231348408
ko05321	Inflammatory bowel disease (IBD)	2/965	56/7206	0.0282181210298
ko04658	Th1 and Th2 cell differentiation	6/965	96/7206	0.0346910050277
ko05166	HTLV-I infection	27/965	292/7206	0.0348609090201
ko04550	Signaling pathways regulating pluripotency of stem cells	13/965	165/7206	0.0366402484543
ko04657	IL-17 signaling pathway	5/965	87/7206	0.0377472745363
ko05133	Pertussis	5/965	87/7206	0.0377472745363
ko04115	p53 signaling pathway	4/965	74/7206	0.0392767170689
ko05418	Fluid shear stress and atherosclerosis	14/965	173/7206	0.0411143660457