ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	186/1103	423/7206	1.7955338398e-48
ko05033	Nicotine addiction	49/1103	56/7206	3.561528748e-33
ko04724	Glutamatergic synapse	85/1103	152/7206	1.39091057699e-31
ko05032	Morphine addiction	68/1103	110/7206	4.30259564327e-29
ko04713	Circadian entrainment	73/1103	136/7206	9.85139126228e-26
ko04727	GABAergic synapse	64/1103	110/7206	2.54761091336e-25
ko04728	Dopaminergic synapse	81/1103	185/7206	5.74388818682e-21
ko04725	Cholinergic synapse	73/1103	160/7206	2.89787059284e-20
ko04723	Retrograde endocannabinoid signaling	76/1103	175/7206	1.77796639014e-19
ko04721	Synaptic vesicle cycle	46/1103	80/7206	3.09986893089e-18
ko04024	cAMP signaling pathway	97/1103	279/7206	2.41193025042e-16
ko04911	Insulin secretion	54/1103	117/7206	1.48149623861e-15
ko04744	Phototransduction	27/1103	36/7206	1.72791415607e-15
ko04742	Taste transduction	35/1103	61/7206	3.88699735486e-14
ko04726	Serotonergic synapse	57/1103	137/7206	6.6250006597e-14
ko04921	Oxytocin signaling pathway	74/1103	209/7206	2.94429477294e-13
ko04020	Calcium signaling pathway	86/1103	265/7206	9.45318820207e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1103	205/7206	9.65924876914e-12
ko05031	Amphetamine addiction	41/1103	91/7206	1.07166036269e-11
ko04720	Long-term potentiation	41/1103	99/7206	2.73844606919e-10
ko03040	Spliceosome	1/1103	145/7206	1.35821516287e-09
ko05030	Cocaine addiction	31/1103	73/7206	2.06048331464e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1103	74/7206	1.22840063509e-07
ko04970	Salivary secretion	35/1103	95/7206	3.14146220976e-07
ko04925	Aldosterone synthesis and secretion	37/1103	105/7206	3.3888722134e-07
ko04740	Olfactory transduction	30/1103	80/7206	9.13480712317e-07
ko05203	Viral carcinogenesis	16/1103	277/7206	9.26067226507e-07
ko04010	MAPK signaling pathway	82/1103	321/7206	1.05125101085e-06
ko04971	Gastric acid secretion	34/1103	98/7206	1.50592869198e-06
ko05322	Systemic lupus erythematosus	5/1103	151/7206	3.06534219989e-06
ko05164	Influenza A	7/1103	167/7206	6.18615899873e-06
ko04360	Axon guidance	62/1103	233/7206	6.86318252908e-06
ko03013	RNA transport	7/1103	166/7206	9.03522698057e-06
ko04514	Cell adhesion molecules (CAMs)	39/1103	130/7206	1.94868987386e-05
ko04060	Cytokine-cytokine receptor interaction	10/1103	191/7206	2.27783619584e-05
ko04972	Pancreatic secretion	34/1103	111/7206	4.44109369168e-05
ko04022	cGMP-PKG signaling pathway	56/1103	216/7206	4.56373355096e-05
ko04072	Phospholipase D signaling pathway	52/1103	197/7206	4.84547821367e-05
ko05168	Herpes simplex infection	10/1103	182/7206	5.96774040957e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1103	79/7206	9.73495943104e-05
ko04621	NOD-like receptor signaling pathway	8/1103	157/7206	0.000110581855253
ko04141	Protein processing in endoplasmic reticulum	11/1103	184/7206	0.000111295002845
ko05162	Measles	5/1103	120/7206	0.000168298245429
ko04070	Phosphatidylinositol signaling system	32/1103	112/7206	0.000287814793697
ko04260	Cardiac muscle contraction	29/1103	98/7206	0.000311548216261
ko03008	Ribosome biogenesis in eukaryotes	2/1103	79/7206	0.00041045419431
ko04612	Antigen processing and presentation	2/1103	77/7206	0.000622159290938
ko04730	Long-term depression	24/1103	78/7206	0.000662010625009
ko05414	Dilated cardiomyopathy	31/1103	112/7206	0.000778105391403
ko04745	Phototransduction - fly	14/1103	38/7206	0.000931816848289
ko05205	Proteoglycans in cancer	23/1103	271/7206	0.00101486604851
ko04110	Cell cycle	9/1103	145/7206	0.00102086581775
ko05161	Hepatitis B	12/1103	173/7206	0.00121806581439
ko04924	Renin secretion	25/1103	86/7206	0.00124113793859
ko04750	Inflammatory mediator regulation of TRP channels	32/1103	122/7206	0.00143670887433
ko05169	Epstein-Barr virus infection	16/1103	206/7206	0.00155975371786
ko04540	Gap junction	33/1103	128/7206	0.00179613028471
ko04710	Circadian rhythm	15/1103	43/7206	0.00196207915857
ko00240	Pyrimidine metabolism	6/1103	110/7206	0.00197414213587
ko04610	Complement and coagulation cascades	3/1103	79/7206	0.00236621794324
ko05110	Vibrio cholerae infection	19/1103	63/7206	0.00240398253968
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1103	14/7206	0.00246311772518
ko04014	Ras signaling pathway	61/1103	279/7206	0.00290209905319
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1103	59/7206	0.00294945579245
ko04915	Estrogen signaling pathway	33/1103	131/7206	0.00300103445239
ko00590	Arachidonic acid metabolism	1/1103	52/7206	0.0031128477113
ko05140	Leishmaniasis	3/1103	75/7206	0.00330380867923
ko04966	Collecting duct acid secretion	10/1103	26/7206	0.0034499308057
ko04064	NF-kappa B signaling pathway	5/1103	96/7206	0.00383115961717
ko04976	Bile secretion	22/1103	80/7206	0.00446694462951
ko04120	Ubiquitin mediated proteolysis	10/1103	138/7206	0.00577034944902
ko04923	Regulation of lipolysis in adipocytes	21/1103	77/7206	0.00619358049357
ko04930	Type II diabetes mellitus	16/1103	54/7206	0.00680893363633
ko03420	Nucleotide excision repair	1/1103	46/7206	0.00694862742036
ko04146	Peroxisome	5/1103	89/7206	0.00725693737702
ko04711	Circadian rhythm - fly	6/1103	13/7206	0.00827312017608
ko04964	Proximal tubule bicarbonate reclamation	10/1103	29/7206	0.0084315948234
ko05321	Inflammatory bowel disease (IBD)	2/1103	56/7206	0.00869256457301
ko04657	IL-17 signaling pathway	5/1103	87/7206	0.0101127663991
ko05133	Pertussis	5/1103	87/7206	0.0101127663991
ko03022	Basal transcription factors	1/1103	44/7206	0.0104203625495
ko04510	Focal adhesion	23/1103	240/7206	0.0105210051688
ko05144	Malaria	1/1103	45/7206	0.0107574029721
ko00071	Fatty acid degradation	1/1103	45/7206	0.0107574029721
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1103	182/7206	0.0119757311499
ko05016	Huntington's disease	20/1103	215/7206	0.0120772865178
ko00480	Glutathione metabolism	2/1103	55/7206	0.0129110272803
ko03018	RNA degradation	5/1103	84/7206	0.01389859023
ko04115	p53 signaling pathway	4/1103	74/7206	0.014059464934
ko05131	Shigellosis	5/1103	82/7206	0.0193565396095
ko00330	Arginine and proline metabolism	3/1103	61/7206	0.0193950707197
ko04622	RIG-I-like receptor signaling pathway	3/1103	62/7206	0.0196818893488
ko03410	Base excision repair	1/1103	38/7206	0.0229895497356
ko04918	Thyroid hormone synthesis	21/1103	86/7206	0.0234086408665
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1103	100/7206	0.0239257973781
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1103	40/7206	0.0242760468863
ko04922	Glucagon signaling pathway	29/1103	128/7206	0.0252218936664
ko05130	Pathogenic Escherichia coli infection	5/1103	77/7206	0.0259654648928
ko04371	Apelin signaling pathway	38/1103	177/7206	0.0260341989262
ko00260	Glycine, serine and threonine metabolism	2/1103	48/7206	0.026297941541
ko05219	Bladder cancer	2/1103	48/7206	0.026297941541
ko03320	PPAR signaling pathway	4/1103	69/7206	0.0273572113113
ko05231	Choline metabolism in cancer	30/1103	134/7206	0.0284473292662
ko04658	Th1 and Th2 cell differentiation	7/1103	96/7206	0.0308889081762
ko05215	Prostate cancer	9/1103	111/7206	0.0329265606945
ko00500	Starch and sucrose metabolism	1/1103	35/7206	0.0341535926807
ko04217	Necroptosis	17/1103	178/7206	0.0342388781022
ko00982	Drug metabolism - cytochrome P450	1/1103	37/7206	0.0354762151823
ko00562	Inositol phosphate metabolism	21/1103	89/7206	0.0369904043271
ko05416	Viral myocarditis	3/1103	55/7206	0.0383612663717
ko04912	GnRH signaling pathway	27/1103	122/7206	0.041765039459
ko04114	Oocyte meiosis	30/1103	139/7206	0.0429750268289
ko04722	Neurotrophin signaling pathway	34/1103	160/7206	0.044704688231
ko04626	Plant-pathogen interaction	6/1103	18/7206	0.0454834033516
ko04210	Apoptosis	18/1103	180/7206	0.0460650206662
ko04214	Apoptosis - fly	5/1103	72/7206	0.047756400414
ko00310	Lysine degradation	5/1103	73/7206	0.0481985663823
ko04620	Toll-like receptor signaling pathway	8/1103	100/7206	0.0486137535562
ko04630	Jak-STAT signaling pathway	12/1103	132/7206	0.0499471749781