ko pathway ratio_in_study ratio_in_pop p_value ko04974 Protein digestion and absorption 30/521 96/7206 1.9976983403e-12 ko04020 Calcium signaling pathway 49/521 265/7206 5.19210491191e-10 ko04740 Olfactory transduction 22/521 80/7206 2.64135080527e-08 ko04972 Pancreatic secretion 26/521 111/7206 5.42829433592e-08 ko04080 Neuroactive ligand-receptor interaction 61/521 423/7206 1.06059245558e-07 ko04971 Gastric acid secretion 23/521 98/7206 3.09281253164e-07 ko04976 Bile secretion 20/521 80/7206 6.23584990559e-07 ko04744 Phototransduction 13/521 36/7206 6.25482506639e-07 ko04970 Salivary secretion 20/521 95/7206 1.08259883815e-05 ko04713 Circadian entrainment 25/521 136/7206 1.13674504306e-05 ko05166 HTLV-I infection 5/521 292/7206 2.52423392813e-05 ko04978 Mineral absorption 11/521 40/7206 8.52117062418e-05 ko04270 Vascular smooth muscle contraction 25/521 154/7206 0.000107420927647 ko04921 Oxytocin signaling pathway 31/521 209/7206 0.000107776142528 ko00230 Purine metabolism 29/521 194/7206 0.000182541935844 ko05168 Herpes simplex infection 2/521 182/7206 0.000219905878705 ko05203 Viral carcinogenesis 6/521 277/7206 0.000317102930185 ko04742 Taste transduction 13/521 61/7206 0.000332030476877 ko03040 Spliceosome 1/521 145/7206 0.000475654428069 ko05161 Hepatitis B 2/521 173/7206 0.000477160587623 ko05033 Nicotine addiction 12/521 56/7206 0.000530321896558 ko04724 Glutamatergic synapse 23/521 152/7206 0.000660709138254 ko04550 Signaling pathways regulating pluripotency of stem cells 2/521 165/7206 0.000664852526039 ko03013 RNA transport 2/521 166/7206 0.000671987969241 ko04022 cGMP-PKG signaling pathway 29/521 216/7206 0.00114781861043 ko04024 cAMP signaling pathway 35/521 279/7206 0.00128105882777 ko00643 Styrene degradation 3/521 4/7206 0.00142261390772 ko04660 T cell receptor signaling pathway 1/521 124/7206 0.00143386160287 ko02010 ABC transporters 9/521 39/7206 0.00150186310761 ko00350 Tyrosine metabolism 8/521 33/7206 0.00195151158584 ko05322 Systemic lupus erythematosus 2/521 151/7206 0.00206901420808 ko05162 Measles 1/521 120/7206 0.00210403205993 ko00830 Retinol metabolism 9/521 42/7206 0.00260252755622 ko05167 Kaposi's sarcoma-associated herpesvirus infection 4/521 191/7206 0.00264421103455 ko04540 Gap junction 19/521 128/7206 0.00268067036455 ko04110 Cell cycle 2/521 145/7206 0.00294091578648 ko04925 Aldosterone synthesis and secretion 16/521 105/7206 0.00371916039165 ko05200 Pathways in cancer 20/521 492/7206 0.00374580039082 ko04964 Proximal tubule bicarbonate reclamation 7/521 29/7206 0.00381516889688 ko05169 Epstein-Barr virus infection 5/521 206/7206 0.00383363870275 ko04924 Renin secretion 14/521 86/7206 0.0047180720897 ko04745 Phototransduction - fly 8/521 38/7206 0.00499439204875 ko04726 Serotonergic synapse 19/521 137/7206 0.00653700287312 ko00140 Steroid hormone biosynthesis 8/521 41/7206 0.0080631860159 ko00190 Oxidative phosphorylation 2/521 127/7206 0.00839428605315 ko00380 Tryptophan metabolism 9/521 50/7206 0.00873729684483 ko00983 Drug metabolism - other enzymes 8/521 42/7206 0.00934804682987 ko05100 Bacterial invasion of epithelial cells 1/521 99/7206 0.00967163366435 ko04620 Toll-like receptor signaling pathway 1/521 100/7206 0.00982238086603 ko04144 Endocytosis 13/521 342/7206 0.00988594888102 ko04668 TNF signaling pathway 2/521 120/7206 0.0117642056064 ko00120 Primary bile acid biosynthesis 5/521 20/7206 0.0120926903284 ko04730 Long-term depression 12/521 78/7206 0.0124411430422 ko04150 mTOR signaling pathway 5/521 184/7206 0.0133357889581 ko03015 mRNA surveillance pathway 1/521 93/7206 0.0139982370848 ko04727 GABAergic synapse 15/521 110/7206 0.0147213311962 ko05032 Morphine addiction 15/521 110/7206 0.0147213311962 ko04720 Long-term potentiation 14/521 99/7206 0.0163042181158 ko04380 Osteoclast differentiation 3/521 134/7206 0.0178439622347 ko04218 Cellular senescence 5/521 177/7206 0.0179018933292 ko04217 Necroptosis 5/521 178/7206 0.0180006323185 ko04662 B cell receptor signaling pathway 1/521 88/7206 0.0204560649114 ko05204 Chemical carcinogenesis 8/521 48/7206 0.0204563529992 ko05323 Rheumatoid arthritis 1/521 89/7206 0.0207736025122 ko04725 Cholinergic synapse 19/521 160/7206 0.0294316833926 ko00360 Phenylalanine metabolism 4/521 17/7206 0.0301889279016 ko00340 Histidine metabolism 5/521 25/7206 0.0307726585394 ko05202 Transcriptional misregulation in cancer 6/521 188/7206 0.0308186886769 ko05164 Influenza A 5/521 167/7206 0.0326587895506 ko04659 Th17 cell differentiation 2/521 106/7206 0.0344708320405 ko04975 Fat digestion and absorption 6/521 35/7206 0.0374031986577 ko05031 Amphetamine addiction 12/521 91/7206 0.0385497230795 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/521 11/7206 0.0400479637067 ko05205 Proteoglycans in cancer 11/521 271/7206 0.0411758922507 ko05140 Leishmaniasis 1/521 75/7206 0.0422623523174 ko05130 Pathogenic Escherichia coli infection 1/521 77/7206 0.0429533937081 ko04664 Fc epsilon RI signaling pathway 1/521 77/7206 0.0429533937081 ko05016 Huntington's disease 8/521 215/7206 0.0439686044636 ko04931 Insulin resistance 4/521 137/7206 0.0453893848349 ko05211 Renal cell carcinoma 2/521 96/7206 0.0463218538693 ko04064 NF-kappa B signaling pathway 2/521 96/7206 0.0463218538693 ko04650 Natural killer cell mediated cytotoxicity 2/521 97/7206 0.0464967621279 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 5/521 28/7206 0.0476930066922