ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1140	423/7206	3.01957082562e-53
ko04724	Glutamatergic synapse	90/1140	152/7206	6.13741352463e-35
ko05033	Nicotine addiction	50/1140	56/7206	4.47597212433e-34
ko05032	Morphine addiction	71/1140	110/7206	3.76327942662e-31
ko04727	GABAergic synapse	69/1140	110/7206	3.64656139978e-29
ko04713	Circadian entrainment	77/1140	136/7206	3.47845924061e-28
ko04728	Dopaminergic synapse	88/1140	185/7206	8.58815212895e-25
ko04723	Retrograde endocannabinoid signaling	80/1140	175/7206	3.0571281012e-21
ko04725	Cholinergic synapse	74/1140	160/7206	4.31764932548e-20
ko04024	cAMP signaling pathway	101/1140	279/7206	1.73439404521e-17
ko04721	Synaptic vesicle cycle	45/1140	80/7206	8.70501023405e-17
ko04744	Phototransduction	27/1140	36/7206	4.03862095307e-15
ko04020	Calcium signaling pathway	93/1140	265/7206	5.20299741424e-15
ko04911	Insulin secretion	54/1140	117/7206	6.31773898695e-15
ko04726	Serotonergic synapse	58/1140	137/7206	6.99613149757e-14
ko04921	Oxytocin signaling pathway	75/1140	209/7206	6.02222715039e-13
ko04742	Taste transduction	34/1140	61/7206	7.71133467665e-13
ko05031	Amphetamine addiction	41/1140	91/7206	3.16469197093e-11
ko04720	Long-term potentiation	43/1140	99/7206	4.59928088426e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1140	205/7206	7.31539973926e-11
ko03040	Spliceosome	1/1140	145/7206	5.13355209037e-10
ko04740	Olfactory transduction	36/1140	80/7206	5.3241161648e-10
ko04925	Aldosterone synthesis and secretion	40/1140	105/7206	3.40160309332e-08
ko04970	Salivary secretion	37/1140	95/7206	3.73448183938e-08
ko04360	Axon guidance	69/1140	233/7206	7.19210238053e-08
ko05203	Viral carcinogenesis	15/1140	277/7206	8.51124775606e-08
ko05030	Cocaine addiction	30/1140	73/7206	1.81258576243e-07
ko04971	Gastric acid secretion	35/1140	98/7206	1.05691909134e-06
ko05322	Systemic lupus erythematosus	5/1140	151/7206	1.33909684525e-06
ko04010	MAPK signaling pathway	83/1140	321/7206	2.19064309765e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1140	74/7206	3.33390314659e-06
ko03013	RNA transport	7/1140	166/7206	4.1811810149e-06
ko04730	Long-term depression	28/1140	78/7206	1.22095432705e-05
ko04141	Protein processing in endoplasmic reticulum	10/1140	184/7206	2.11024393832e-05
ko04072	Phospholipase D signaling pathway	54/1140	197/7206	2.59422884717e-05
ko04972	Pancreatic secretion	35/1140	111/7206	3.20914184486e-05
ko04621	NOD-like receptor signaling pathway	8/1140	157/7206	5.33459509046e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1140	79/7206	6.10159332286e-05
ko04060	Cytokine-cytokine receptor interaction	12/1140	191/7206	7.67595911377e-05
ko05168	Herpes simplex infection	11/1140	182/7206	7.77943179374e-05
ko04745	Phototransduction - fly	16/1140	38/7206	9.65340455255e-05
ko04022	cGMP-PKG signaling pathway	56/1140	216/7206	0.000131031722086
ko05164	Influenza A	10/1140	167/7206	0.00014766839511
ko04070	Phosphatidylinositol signaling system	33/1140	112/7206	0.000216956465708
ko04260	Cardiac muscle contraction	30/1140	98/7206	0.000218125405257
ko04514	Cell adhesion molecules (CAMs)	37/1140	130/7206	0.000224361816361
ko04610	Complement and coagulation cascades	2/1140	79/7206	0.000266213396542
ko03008	Ribosome biogenesis in eukaryotes	2/1140	79/7206	0.000266213396542
ko04540	Gap junction	36/1140	128/7206	0.000337438113749
ko04612	Antigen processing and presentation	2/1140	77/7206	0.00040306065289
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1140	59/7206	0.000501956882838
ko05414	Dilated cardiomyopathy	32/1140	112/7206	0.000573383680226
ko04750	Inflammatory mediator regulation of TRP channels	34/1140	122/7206	0.00062533797567
ko04110	Cell cycle	9/1140	145/7206	0.000743932775788
ko00480	Glutathione metabolism	1/1140	55/7206	0.0013353465096
ko05162	Measles	7/1140	120/7206	0.00141609874146
ko05205	Proteoglycans in cancer	25/1140	271/7206	0.00163545969582
ko04711	Circadian rhythm - fly	7/1140	13/7206	0.00173288412876
ko04146	Peroxisome	4/1140	89/7206	0.00180281271078
ko05169	Epstein-Barr virus infection	17/1140	206/7206	0.0018075040849
ko05140	Leishmaniasis	3/1140	75/7206	0.00222997209472
ko04014	Ras signaling pathway	63/1140	279/7206	0.00249935138651
ko04064	NF-kappa B signaling pathway	5/1140	96/7206	0.00270236737105
ko00240	Pyrimidine metabolism	7/1140	110/7206	0.00363405712529
ko04924	Renin secretion	24/1140	86/7206	0.00418191542449
ko04966	Collecting duct acid secretion	10/1140	26/7206	0.00441477826101
ko04915	Estrogen signaling pathway	33/1140	131/7206	0.00511143014672
ko04710	Circadian rhythm	14/1140	43/7206	0.00547005322387
ko04912	GnRH signaling pathway	31/1140	122/7206	0.00558211461605
ko04371	Apelin signaling pathway	42/1140	177/7206	0.00634244249756
ko05144	Malaria	1/1140	45/7206	0.00679934245171
ko00071	Fatty acid degradation	1/1140	45/7206	0.00679934245171
ko03420	Nucleotide excision repair	1/1140	46/7206	0.00699074881499
ko04976	Bile secretion	22/1140	80/7206	0.00789295529209
ko05321	Inflammatory bowel disease (IBD)	2/1140	56/7206	0.00874439887062
ko05110	Vibrio cholerae infection	18/1140	63/7206	0.00876167478079
ko04120	Ubiquitin mediated proteolysis	11/1140	138/7206	0.00912356555269
ko04640	Hematopoietic cell lineage	3/1140	64/7206	0.00943685182257
ko03022	Basal transcription factors	1/1140	44/7206	0.0107916417687
ko04923	Regulation of lipolysis in adipocytes	21/1140	77/7206	0.0108407399102
ko00330	Arginine and proline metabolism	3/1140	61/7206	0.0134550832482
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1140	14/7206	0.0148057316081
ko05161	Hepatitis B	16/1140	173/7206	0.0149468754973
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1140	40/7206	0.0152404017761
ko00140	Steroid hormone biosynthesis	1/1140	41/7206	0.0157585045114
ko05133	Pertussis	6/1140	87/7206	0.0177584657865
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1140	100/7206	0.0179166787678
ko05166	HTLV-I infection	32/1140	292/7206	0.0215213055029
ko05016	Huntington's disease	22/1140	215/7206	0.0223962188739
ko00982	Drug metabolism - cytochrome P450	1/1140	37/7206	0.0226106207805
ko04658	Th1 and Th2 cell differentiation	7/1140	96/7206	0.0229976202735
ko05231	Choline metabolism in cancer	31/1140	134/7206	0.0230620207488
ko03410	Base excision repair	1/1140	38/7206	0.0230983494315
ko04930	Type II diabetes mellitus	15/1140	54/7206	0.0231263585729
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1140	182/7206	0.0236353292556
ko03018	RNA degradation	6/1140	84/7206	0.0240466632043
ko01524	Platinum drug resistance	5/1140	76/7206	0.025707498393
ko00260	Glycine, serine and threonine metabolism	2/1140	48/7206	0.0265602669311
ko04071	Sphingolipid signaling pathway	36/1140	162/7206	0.0290142681626
ko04630	Jak-STAT signaling pathway	12/1140	132/7206	0.0301283299641
ko04062	Chemokine signaling pathway	43/1140	201/7206	0.0311244462416
ko05131	Shigellosis	6/1140	82/7206	0.0323894648149
ko04214	Apoptosis - fly	5/1140	72/7206	0.0347549420443
ko00310	Lysine degradation	5/1140	73/7206	0.0349051066104
ko04115	p53 signaling pathway	5/1140	74/7206	0.0355285941371
ko04918	Thyroid hormone synthesis	21/1140	86/7206	0.0362615405983
ko04964	Proximal tubule bicarbonate reclamation	9/1140	29/7206	0.0370495083916
ko04722	Neurotrophin signaling pathway	35/1140	160/7206	0.037465869915
ko00280	Valine, leucine and isoleucine degradation	3/1140	54/7206	0.0379701861534
ko04142	Lysosome	15/1140	151/7206	0.0427803120774
ko05034	Alcoholism	49/1140	238/7206	0.0465102031423
ko03320	PPAR signaling pathway	5/1140	69/7206	0.0471443039266
ko04113	Meiosis - yeast	5/1140	70/7206	0.0472085511774
ko05215	Prostate cancer	10/1140	111/7206	0.0487648341237
ko05145	Toxoplasmosis	12/1140	126/7206	0.0490507515405