ko pathway ratio_in_study ratio_in_pop p_value ko03010 Ribosome 44/342 129/7206 6.94275368103e-27 ko04380 Osteoclast differentiation 21/342 134/7206 1.10731325358e-06 ko04621 NOD-like receptor signaling pathway 23/342 157/7206 1.15208439986e-06 ko04060 Cytokine-cytokine receptor interaction 24/342 191/7206 1.05800326638e-05 ko05164 Influenza A 22/342 167/7206 1.16484046886e-05 ko04623 Cytosolic DNA-sensing pathway 10/342 41/7206 1.52565922761e-05 ko05131 Shigellosis 14/342 82/7206 2.62286806729e-05 ko04668 TNF signaling pathway 17/342 120/7206 4.57389314822e-05 ko04666 Fc gamma R-mediated phagocytosis 17/342 122/7206 5.66894914341e-05 ko05132 Salmonella infection 14/342 98/7206 0.000195279279083 ko04080 Neuroactive ligand-receptor interaction 6/342 423/7206 0.000228011193392 ko04660 T cell receptor signaling pathway 16/342 124/7206 0.000234268509865 ko00643 Styrene degradation 3/342 4/7206 0.000409082327856 ko00980 Metabolism of xenobiotics by cytochrome P450 8/342 40/7206 0.000480097618841 ko05168 Herpes simplex infection 20/342 182/7206 0.000497450574499 ko04064 NF-kappa B signaling pathway 13/342 96/7206 0.000558983931489 ko04622 RIG-I-like receptor signaling pathway 10/342 62/7206 0.00060162085105 ko04662 B cell receptor signaling pathway 12/342 88/7206 0.00085017590848 ko00982 Drug metabolism - cytochrome P450 7/342 37/7206 0.00152978096723 ko05162 Measles 14/342 120/7206 0.0015576565429 ko05204 Chemical carcinogenesis 8/342 48/7206 0.00169189332145 ko04620 Toll-like receptor signaling pathway 12/342 100/7206 0.00261122411883 ko05016 Huntington's disease 2/342 215/7206 0.00304924633546 ko05130 Pathogenic Escherichia coli infection 10/342 77/7206 0.00326820362979 ko05034 Alcoholism 3/342 238/7206 0.00500987084723 ko04630 Jak-STAT signaling pathway 14/342 132/7206 0.00534916310093 ko04650 Natural killer cell mediated cytotoxicity 11/342 97/7206 0.0059970013346 ko04217 Necroptosis 17/342 178/7206 0.00610242143361 ko04210 Apoptosis 17/342 180/7206 0.00650867334292 ko05100 Bacterial invasion of epithelial cells 11/342 99/7206 0.00698729221983 ko04020 Calcium signaling pathway 4/342 265/7206 0.00743798589317 ko04657 IL-17 signaling pathway 10/342 87/7206 0.00784877415576 ko05133 Pertussis 10/342 87/7206 0.00784877415576 ko05134 Legionellosis 9/342 74/7206 0.00796136148176 ko05323 Rheumatoid arthritis 10/342 89/7206 0.00917851268584 ko00051 Fructose and mannose metabolism 6/342 42/7206 0.0135152596688 ko05167 Kaposi's sarcoma-associated herpesvirus infection 17/342 191/7206 0.0138181607245 ko04110 Cell cycle 1/342 145/7206 0.0154727329166 ko04142 Lysosome 14/342 151/7206 0.0174407228267 ko04723 Retrograde endocannabinoid signaling 2/342 175/7206 0.0177360514246 ko04062 Chemokine signaling pathway 17/342 201/7206 0.0177668326787 ko00350 Tyrosine metabolism 5/342 33/7206 0.0185641040911 ko04151 PI3K-Akt signaling pathway 9/342 390/7206 0.0190747397245 ko00281 Geraniol degradation 2/342 5/7206 0.0204158492649 ko04215 Apoptosis - multiple species 6/342 47/7206 0.0227166809942 ko04550 Signaling pathways regulating pluripotency of stem cells 2/342 165/7206 0.0247945570582 ko03013 RNA transport 2/342 166/7206 0.0249037716551 ko05140 Leishmaniasis 8/342 75/7206 0.0250722586548 ko05150 Staphylococcus aureus infection 5/342 36/7206 0.0262807592316 ko01524 Platinum drug resistance 8/342 76/7206 0.026910342822 ko04750 Inflammatory mediator regulation of TRP channels 1/342 122/7206 0.0308476368384 ko04066 HIF-1 signaling pathway 1/342 123/7206 0.0308929761965 ko00190 Oxidative phosphorylation 1/342 127/7206 0.0317496262982 ko00040 Pentose and glucuronate interconversions 4/342 26/7206 0.032609639269 ko05160 Hepatitis C 13/342 153/7206 0.0342690293213 ko00520 Amino sugar and nucleotide sugar metabolism 6/342 55/7206 0.0448523151239 ko00480 Glutathione metabolism 6/342 55/7206 0.0448523151239 ko05161 Hepatitis B 14/342 173/7206 0.0448715739665 ko04911 Insulin secretion 1/342 117/7206 0.0450167726575 ko00966 Glucosinolate biosynthesis 1/342 1/7206 0.0474604496254 ko00626 Naphthalene degradation 1/342 1/7206 0.0474604496254 ko00401 Novobiocin biosynthesis 1/342 1/7206 0.0474604496254 ko04310 Wnt signaling pathway 3/342 181/7206 0.049201044317 ko05322 Systemic lupus erythematosus 2/342 151/7206 0.0495767233732