ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 80/252 423/7206 4.5689172903e-39 ko05033 Nicotine addiction 25/252 56/7206 2.54805846651e-22 ko04724 Glutamatergic synapse 35/252 152/7206 9.27559297483e-20 ko04742 Taste transduction 17/252 61/7206 1.38600322534e-11 ko04024 cAMP signaling pathway 33/252 279/7206 4.75184401773e-10 ko04728 Dopaminergic synapse 26/252 185/7206 9.4655309684e-10 ko04020 Calcium signaling pathway 31/252 265/7206 2.21018498686e-09 ko05030 Cocaine addiction 16/252 73/7206 2.75569871393e-09 ko04723 Retrograde endocannabinoid signaling 24/252 175/7206 7.16644805773e-09 ko05031 Amphetamine addiction 17/252 91/7206 1.15657730569e-08 ko04727 GABAergic synapse 18/252 110/7206 3.73363982039e-08 ko05032 Morphine addiction 18/252 110/7206 3.73363982039e-08 ko04720 Long-term potentiation 17/252 99/7206 4.32129884578e-08 ko04713 Circadian entrainment 19/252 136/7206 2.11130272445e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 12/252 74/7206 8.20506241525e-06 ko04726 Serotonergic synapse 15/252 137/7206 8.03936477903e-05 ko04261 Adrenergic signaling in cardiomyocytes 19/252 205/7206 9.29139956882e-05 ko05200 Pathways in cancer 5/252 492/7206 0.000796147460184 ko05203 Viral carcinogenesis 1/252 277/7206 0.00114870458163 ko04921 Oxytocin signaling pathway 17/252 209/7206 0.00151697248614 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9/252 79/7206 0.00164341318369 ko04260 Cardiac muscle contraction 10/252 98/7206 0.00213903995035 ko04072 Phospholipase D signaling pathway 16/252 197/7206 0.00222797716338 ko04911 Insulin secretion 11/252 117/7206 0.00251785058561 ko05414 Dilated cardiomyopathy 10/252 112/7206 0.00564534959783 ko04730 Long-term depression 8/252 78/7206 0.0056613994795 ko05034 Alcoholism 17/252 238/7206 0.00576245731771 ko04970 Salivary secretion 9/252 95/7206 0.0057856343127 ko04740 Olfactory transduction 8/252 80/7206 0.00659387006938 ko04744 Phototransduction 5/252 36/7206 0.00780379566181 ko05410 Hypertrophic cardiomyopathy (HCM) 9/252 100/7206 0.00805796427342 ko04014 Ras signaling pathway 18/252 279/7206 0.0114026270197 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/252 26/7206 0.0119046732556 ko04725 Cholinergic synapse 12/252 160/7206 0.013256210082 ko04060 Cytokine-cytokine receptor interaction 1/252 191/7206 0.0151611143873 ko05167 Kaposi's sarcoma-associated herpesvirus infection 1/252 191/7206 0.0151611143873 ko04972 Pancreatic secretion 9/252 111/7206 0.0153887568397 ko00512 Mucin type O-glycan biosynthesis 4/252 29/7206 0.0174317740696 ko04971 Gastric acid secretion 8/252 98/7206 0.0209794569389 ko04150 mTOR signaling pathway 1/252 184/7206 0.0224718323741 ko05205 Proteoglycans in cancer 3/252 271/7206 0.0265369665942 ko00510 N-Glycan biosynthesis 5/252 50/7206 0.0295996478466 ko04550 Signaling pathways regulating pluripotency of stem cells 1/252 165/7206 0.0314135346283 ko03013 RNA transport 1/252 166/7206 0.0314185052553 ko05418 Fluid shear stress and atherosclerosis 1/252 173/7206 0.0324844285493 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/252 1/7206 0.0349708576187 ko00562 Inositol phosphate metabolism 7/252 89/7206 0.035666484903 ko04140 Autophagy - animal 1/252 164/7206 0.0477661928108 ko05166 HTLV-I infection 4/252 292/7206 0.0484247924497 ko04915 Estrogen signaling pathway 9/252 131/7206 0.0487131944216 ko04510 Focal adhesion 3/252 240/7206 0.0492126839619