ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 30/530 68/7206 5.7467582552e-17 ko03040 Spliceosome 39/530 145/7206 3.61912576525e-13 ko04390 Hippo signaling pathway 44/530 188/7206 2.1248303e-12 ko04550 Signaling pathways regulating pluripotency of stem cells 40/530 165/7206 6.82036680614e-12 ko04080 Neuroactive ligand-receptor interaction 3/530 423/7206 6.54032980192e-11 ko03030 DNA replication 16/530 38/7206 2.85650936106e-09 ko04110 Cell cycle 33/530 145/7206 2.88817667725e-09 ko05224 Breast cancer 36/530 174/7206 8.4017681092e-09 ko04310 Wnt signaling pathway 36/530 181/7206 2.503140977e-08 ko03015 mRNA surveillance pathway 24/530 93/7206 3.33919190295e-08 ko05205 Proteoglycans in cancer 44/530 271/7206 5.56939513543e-07 ko05200 Pathways in cancer 66/530 492/7206 9.96702774077e-07 ko03410 Base excision repair 13/530 38/7206 1.55577230611e-06 ko04340 Hedgehog signaling pathway 15/530 58/7206 1.25631249803e-05 ko04020 Calcium signaling pathway 4/530 265/7206 2.0503762629e-05 ko04111 Cell cycle - yeast 19/530 90/7206 2.19186699528e-05 ko04330 Notch signaling pathway 15/530 62/7206 2.98353958837e-05 ko04113 Meiosis - yeast 16/530 70/7206 3.47762814546e-05 ko05166 HTLV-I infection 40/530 292/7206 0.000125007171535 ko04724 Glutamatergic synapse 1/530 152/7206 0.000211212918127 ko05010 Alzheimer's disease 3/530 202/7206 0.000293432570643 ko04350 TGF-beta signaling pathway 18/530 103/7206 0.000451513722411 ko00240 Pyrimidine metabolism 19/530 110/7206 0.000578421169726 ko04921 Oxytocin signaling pathway 4/530 209/7206 0.000684519649392 ko04950 Maturity onset diabetes of the young 8/530 29/7206 0.000873571468581 ko03010 Ribosome 1/530 129/7206 0.000974021108022 ko04360 Axon guidance 31/530 233/7206 0.00121936783421 ko03013 RNA transport 24/530 166/7206 0.00129173746684 ko04062 Chemokine signaling pathway 4/530 201/7206 0.00137710558232 ko04910 Insulin signaling pathway 3/530 172/7206 0.00167298857202 ko04723 Retrograde endocannabinoid signaling 3/530 175/7206 0.00173095836295 ko04916 Melanogenesis 21/530 142/7206 0.00175445100751 ko04072 Phospholipase D signaling pathway 4/530 197/7206 0.00197893988975 ko04070 Phosphatidylinositol signaling system 1/530 112/7206 0.00305711686815 ko04391 Hippo signaling pathway - fly 15/530 90/7206 0.00314688347047 ko05206 MicroRNAs in cancer 24/530 177/7206 0.00314892445304 ko04725 Cholinergic synapse 3/530 160/7206 0.00332850185884 ko05231 Choline metabolism in cancer 2/530 134/7206 0.00403777451909 ko05202 Transcriptional misregulation in cancer 25/530 188/7206 0.00404132826016 ko04726 Serotonergic synapse 2/530 137/7206 0.00418563926771 ko04727 GABAergic synapse 1/530 110/7206 0.00468229427405 ko04621 NOD-like receptor signaling pathway 3/530 157/7206 0.0047567636578 ko00514 Other types of O-glycan biosynthesis 7/530 30/7206 0.00513566696044 ko04630 Jak-STAT signaling pathway 2/530 132/7206 0.00604082017567 ko05222 Small cell lung cancer 14/530 89/7206 0.00620735290394 ko04211 Longevity regulating pathway 2/530 123/7206 0.00822084881437 ko00230 Purine metabolism 24/530 194/7206 0.011257128768 ko04217 Necroptosis 5/530 178/7206 0.0131729229756 ko04144 Endocytosis 14/530 342/7206 0.0145036841033 ko00261 Monobactam biosynthesis 2/530 3/7206 0.0154087781915 ko03050 Proteasome 9/530 54/7206 0.0159189262487 ko04022 cGMP-PKG signaling pathway 7/530 216/7206 0.0163503079032 ko03420 Nucleotide excision repair 8/530 46/7206 0.0176374629562 ko04915 Estrogen signaling pathway 3/530 131/7206 0.0177997852009 ko00562 Inositol phosphate metabolism 1/530 89/7206 0.0214081575368 ko01200 Carbon metabolism 3/530 128/7206 0.0248276812951 ko04922 Glucagon signaling pathway 3/530 128/7206 0.0248276812951 ko04612 Antigen processing and presentation 11/530 77/7206 0.0270698853941 ko04610 Complement and coagulation cascades 1/530 79/7206 0.0291165578536 ko04138 Autophagy - yeast 1/530 81/7206 0.0295407334859 ko04137 Mitophagy - animal 1/530 82/7206 0.0299924375232 ko05034 Alcoholism 9/530 238/7206 0.0309194565415 ko04666 Fc gamma R-mediated phagocytosis 3/530 122/7206 0.0341774497643 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/530 26/7206 0.0382739549699 ko04371 Apelin signaling pathway 6/530 177/7206 0.0401155368945 ko05169 Epstein-Barr virus infection 23/530 206/7206 0.0412287260355 ko05134 Legionellosis 1/530 74/7206 0.042189206601 ko04713 Circadian entrainment 4/530 136/7206 0.0453812732785 ko04931 Insulin resistance 4/530 137/7206 0.04560510257 ko04024 cAMP signaling pathway 12/530 279/7206 0.0462123642988 ko04260 Cardiac muscle contraction 2/530 98/7206 0.0477200061773 ko04971 Gastric acid secretion 2/530 98/7206 0.0477200061773