ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 53/506 152/7206 2.89343103955e-24 ko04080 Neuroactive ligand-receptor interaction 80/506 423/7206 3.55309463887e-17 ko05033 Nicotine addiction 25/506 56/7206 5.85200896825e-15 ko04713 Circadian entrainment 38/506 136/7206 4.4654432101e-14 ko04723 Retrograde endocannabinoid signaling 41/506 175/7206 2.66067833581e-12 ko04728 Dopaminergic synapse 42/506 185/7206 4.34611524709e-12 ko04727 GABAergic synapse 31/506 110/7206 8.23238423743e-12 ko04721 Synaptic vesicle cycle 26/506 80/7206 1.16862131432e-11 ko04911 Insulin secretion 30/506 117/7206 2.38630130857e-10 ko04720 Long-term potentiation 27/506 99/7206 4.29240498144e-10 ko04726 Serotonergic synapse 31/506 137/7206 3.35722283743e-09 ko05032 Morphine addiction 27/506 110/7206 5.44662050976e-09 ko04921 Oxytocin signaling pathway 39/506 209/7206 1.1330323011e-08 ko04261 Adrenergic signaling in cardiomyocytes 38/506 205/7206 2.12532115851e-08 ko04070 Phosphatidylinositol signaling system 26/506 112/7206 3.64204271119e-08 ko04020 Calcium signaling pathway 44/506 265/7206 5.30055248136e-08 ko04970 Salivary secretion 23/506 95/7206 9.89495109935e-08 ko05031 Amphetamine addiction 22/506 91/7206 1.93543033855e-07 ko04024 cAMP signaling pathway 44/506 279/7206 2.55592406627e-07 ko04725 Cholinergic synapse 30/506 160/7206 5.25806931515e-07 ko04730 Long-term depression 19/506 78/7206 1.17393203074e-06 ko04744 Phototransduction 12/506 36/7206 3.32484755585e-06 ko04260 Cardiac muscle contraction 20/506 98/7206 1.14560817274e-05 ko04514 Cell adhesion molecules (CAMs) 23/506 130/7206 3.02089644527e-05 ko04925 Aldosterone synthesis and secretion 20/506 105/7206 3.32434265278e-05 ko04745 Phototransduction - fly 11/506 38/7206 3.8660242669e-05 ko05168 Herpes simplex infection 1/506 182/7206 4.54294239829e-05 ko04010 MAPK signaling pathway 42/506 321/7206 7.28224944072e-05 ko04972 Pancreatic secretion 20/506 111/7206 7.59514190503e-05 ko05203 Viral carcinogenesis 5/506 277/7206 0.000101859049683 ko04022 cGMP-PKG signaling pathway 31/506 216/7206 0.000114712349492 ko00562 Inositol phosphate metabolism 17/506 89/7206 0.000123795461647 ko05030 Cocaine addiction 15/506 73/7206 0.000131052841956 ko05164 Influenza A 1/506 167/7206 0.000154022205576 ko04742 Taste transduction 13/506 61/7206 0.000249250981522 ko04072 Phospholipase D signaling pathway 28/506 197/7206 0.000310182989921 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/506 79/7206 0.000328426855738 ko05169 Epstein-Barr virus infection 3/506 206/7206 0.000427030198821 ko03040 Spliceosome 1/506 145/7206 0.000456525169844 ko05014 Amyotrophic lateral sclerosis (ALS) 14/506 74/7206 0.000535612087245 ko04060 Cytokine-cytokine receptor interaction 3/506 191/7206 0.000841956723065 ko05110 Vibrio cholerae infection 12/506 63/7206 0.00123881151624 ko04630 Jak-STAT signaling pathway 1/506 132/7206 0.00150871065985 ko04966 Collecting duct acid secretion 7/506 26/7206 0.00163995084099 ko04971 Gastric acid secretion 16/506 98/7206 0.00195622542388 ko05322 Systemic lupus erythematosus 2/506 151/7206 0.00198979028893 ko05205 Proteoglycans in cancer 7/506 271/7206 0.00217718234811 ko05224 Breast cancer 3/506 174/7206 0.00239134925295 ko04924 Renin secretion 14/506 86/7206 0.00245087830671 ko04668 TNF signaling pathway 1/506 120/7206 0.00318706764439 ko05166 HTLV-I infection 9/506 292/7206 0.00473532846279 ko05010 Alzheimer's disease 25/506 202/7206 0.00483401288956 ko04626 Plant-pathogen interaction 5/506 18/7206 0.00666105729024 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/506 59/7206 0.00737144633282 ko00680 Methane metabolism 7/506 34/7206 0.00822932222619 ko04510 Focal adhesion 7/506 240/7206 0.00945875469708 ko05161 Hepatitis B 4/506 173/7206 0.00976014296617 ko04110 Cell cycle 3/506 145/7206 0.0129491712826 ko05200 Pathways in cancer 21/506 492/7206 0.0131760237018 ko04550 Signaling pathways regulating pluripotency of stem cells 4/506 165/7206 0.0133447423561 ko03013 RNA transport 4/506 166/7206 0.0133481883009 ko04964 Proximal tubule bicarbonate reclamation 6/506 29/7206 0.0137907494981 ko05414 Dilated cardiomyopathy 15/506 112/7206 0.0138527884231 ko05211 Renal cell carcinoma 1/506 96/7206 0.0141214225501 ko05410 Hypertrophic cardiomyopathy (HCM) 14/506 100/7206 0.0153542415782 ko04014 Ras signaling pathway 30/506 279/7206 0.0166559026649 ko04120 Ubiquitin mediated proteolysis 3/506 138/7206 0.01793869381 ko04141 Protein processing in endoplasmic reticulum 5/506 184/7206 0.0181868484667 ko05222 Small cell lung cancer 1/506 89/7206 0.0202997079895 ko04540 Gap junction 16/506 128/7206 0.0217407482559 ko05215 Prostate cancer 2/506 111/7206 0.0235779521549 ko05034 Alcoholism 26/506 238/7206 0.0269905249708 ko05218 Melanoma 1/506 85/7206 0.0298458160884 ko04750 Inflammatory mediator regulation of TRP channels 15/506 122/7206 0.0301923156437 ko04657 IL-17 signaling pathway 1/506 87/7206 0.0308989508523 ko04371 Apelin signaling pathway 20/506 177/7206 0.0351428781635 ko04810 Regulation of actin cytoskeleton 10/506 264/7206 0.0360862134115 ko00010 Glycolysis / Gluconeogenesis 10/506 74/7206 0.0375033400166 ko05130 Pathogenic Escherichia coli infection 1/506 77/7206 0.0424341006773 ko01524 Platinum drug resistance 1/506 76/7206 0.0424484473832 ko03008 Ribosome biogenesis in eukaryotes 1/506 79/7206 0.0430066013852 ko04620 Toll-like receptor signaling pathway 2/506 100/7206 0.0467295464113 ko00512 Mucin type O-glycan biosynthesis 5/506 29/7206 0.0489506670846