ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 60/246 423/7206 1.78345270497e-22 ko04724 Glutamatergic synapse 30/246 152/7206 2.21955883477e-15 ko05033 Nicotine addiction 17/246 56/7206 2.0006302113e-12 ko04720 Long-term potentiation 21/246 99/7206 1.01454009547e-11 ko04713 Circadian entrainment 20/246 136/7206 2.7633507459e-08 ko04728 Dopaminergic synapse 23/246 185/7206 6.22654046999e-08 ko04723 Retrograde endocannabinoid signaling 22/246 175/7206 1.00130340458e-07 ko05030 Cocaine addiction 14/246 73/7206 1.2365532888e-07 ko04727 GABAergic synapse 17/246 110/7206 1.51032981581e-07 ko04742 Taste transduction 12/246 61/7206 7.54934697988e-07 ko05032 Morphine addiction 16/246 110/7206 8.27922291884e-07 ko04261 Adrenergic signaling in cardiomyocytes 22/246 205/7206 1.60221621888e-06 ko05031 Amphetamine addiction 14/246 91/7206 2.0628830383e-06 ko04744 Phototransduction 9/246 36/7206 2.28539242272e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 12/246 74/7206 6.40934287629e-06 ko04970 Salivary secretion 13/246 95/7206 1.79517575849e-05 ko04024 cAMP signaling pathway 24/246 279/7206 2.53151171689e-05 ko04020 Calcium signaling pathway 23/246 265/7206 3.2651949567e-05 ko04730 Long-term depression 11/246 78/7206 6.02799244806e-05 ko04921 Oxytocin signaling pathway 19/246 209/7206 8.72713569484e-05 ko04022 cGMP-PKG signaling pathway 18/246 216/7206 0.000396849696191 ko04911 Insulin secretion 12/246 117/7206 0.000609823041706 ko04924 Renin secretion 10/246 86/7206 0.000647009244218 ko04726 Serotonergic synapse 13/246 137/7206 0.00076958450102 ko05034 Alcoholism 18/246 238/7206 0.00146742739545 ko04915 Estrogen signaling pathway 12/246 131/7206 0.00165618434187 ko04260 Cardiac muscle contraction 10/246 98/7206 0.00178979157184 ko00512 Mucin type O-glycan biosynthesis 5/246 29/7206 0.00270031754853 ko04014 Ras signaling pathway 19/246 279/7206 0.00365650521286 ko04072 Phospholipase D signaling pathway 15/246 197/7206 0.00390413246757 ko04972 Pancreatic secretion 10/246 111/7206 0.004477090358 ko05414 Dilated cardiomyopathy 10/246 112/7206 0.00477247564384 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 8/246 79/7206 0.00530000621527 ko04721 Synaptic vesicle cycle 8/246 80/7206 0.00571994645329 ko05203 Viral carcinogenesis 2/246 277/7206 0.00627694026983 ko04966 Collecting duct acid secretion 4/246 26/7206 0.0109642761858 ko04010 MAPK signaling pathway 19/246 321/7206 0.017341773865 ko04371 Apelin signaling pathway 12/246 177/7206 0.0197526555582 ko05110 Vibrio cholerae infection 6/246 63/7206 0.0199416019802 ko04270 Vascular smooth muscle contraction 11/246 154/7206 0.0205210990775 ko05410 Hypertrophic cardiomyopathy (HCM) 8/246 100/7206 0.0205735245708 ko04141 Protein processing in endoplasmic reticulum 1/246 184/7206 0.0219160788169 ko04725 Cholinergic synapse 11/246 160/7206 0.0243607829213 ko05205 Proteoglycans in cancer 3/246 271/7206 0.0261394885049 ko05010 Alzheimer's disease 13/246 202/7206 0.0273606557947 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/246 1/7206 0.0341382181516 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/246 92/7206 0.0372470580038 ko04015 Rap1 signaling pathway 16/246 278/7206 0.0405879529002 ko04540 Gap junction 9/246 128/7206 0.0418945057656 ko04140 Autophagy - animal 1/246 164/7206 0.0461810014097 ko04971 Gastric acid secretion 7/246 98/7206 0.0496648444643