ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 24/491 112/7206 3.46743905912e-07 ko04710 Circadian rhythm 14/491 43/7206 4.82216257226e-07 ko05032 Morphine addiction 19/491 110/7206 0.000137700803964 ko04020 Calcium signaling pathway 35/491 265/7206 0.000148172443215 ko04726 Serotonergic synapse 22/491 137/7206 0.000186004224183 ko04080 Neuroactive ligand-receptor interaction 49/491 423/7206 0.000202589040406 ko04014 Ras signaling pathway 36/491 279/7206 0.000218939474968 ko04024 cAMP signaling pathway 35/491 279/7206 0.000375014372392 ko05322 Systemic lupus erythematosus 1/491 151/7206 0.000463276720579 ko04725 Cholinergic synapse 23/491 160/7206 0.000627451665567 ko04921 Oxytocin signaling pathway 28/491 209/7206 0.000650368101429 ko04925 Aldosterone synthesis and secretion 17/491 105/7206 0.000668643503979 ko03040 Spliceosome 1/491 145/7206 0.000679980728238 ko04750 Inflammatory mediator regulation of TRP channels 19/491 122/7206 0.000712849724125 ko04724 Glutamatergic synapse 22/491 152/7206 0.000823124509766 ko00564 Glycerophospholipid metabolism 16/491 99/7206 0.000973793638755 ko04960 Aldosterone-regulated sodium reabsorption 9/491 41/7206 0.00144325442756 ko03010 Ribosome 1/491 129/7206 0.00217917451676 ko04072 Phospholipase D signaling pathway 25/491 197/7206 0.00228202153327 ko04744 Phototransduction 8/491 36/7206 0.00242495255829 ko04745 Phototransduction - fly 8/491 38/7206 0.00347538832772 ko04919 Thyroid hormone signaling pathway 19/491 143/7206 0.00411148157498 ko05231 Choline metabolism in cancer 18/491 134/7206 0.00490367374911 ko04911 Insulin secretion 16/491 117/7206 0.00792990541149 ko00562 Inositol phosphate metabolism 13/491 89/7206 0.00869389709672 ko05230 Central carbon metabolism in cancer 12/491 81/7206 0.0114640788897 ko04713 Circadian entrainment 17/491 136/7206 0.0144865143002 ko02010 ABC transporters 7/491 39/7206 0.0149296731603 ko04727 GABAergic synapse 14/491 110/7206 0.0204663990998 ko00590 Arachidonic acid metabolism 8/491 52/7206 0.0232339606389 ko04720 Long-term potentiation 13/491 99/7206 0.0236907428845 ko04022 cGMP-PKG signaling pathway 23/491 216/7206 0.0281044497401 ko05203 Viral carcinogenesis 10/491 277/7206 0.0281552428813 ko04930 Type II diabetes mellitus 8/491 54/7206 0.0285478039953 ko04626 Plant-pathogen interaction 4/491 18/7206 0.030308986598 ko05031 Amphetamine addiction 12/491 91/7206 0.0320578759187 ko04922 Glucagon signaling pathway 15/491 128/7206 0.0330976410986 ko00240 Pyrimidine metabolism 2/491 110/7206 0.0336829385881 ko00592 alpha-Linolenic acid metabolism 4/491 19/7206 0.0363863430333 ko04970 Salivary secretion 12/491 95/7206 0.0365356219015 ko04728 Dopaminergic synapse 20/491 185/7206 0.0371984159017 ko04152 AMPK signaling pathway 18/491 161/7206 0.0375755810917 ko04650 Natural killer cell mediated cytotoxicity 12/491 97/7206 0.0396203432332 ko04140 Autophagy - animal 18/491 164/7206 0.04037254051 ko04971 Gastric acid secretion 12/491 98/7206 0.0413769801131 ko04730 Long-term depression 10/491 78/7206 0.0419695001395 ko04512 ECM-receptor interaction 1/491 79/7206 0.0426099598615 ko04110 Cell cycle 4/491 145/7206 0.0457523594284 ko04912 GnRH signaling pathway 14/491 122/7206 0.0458990295678