ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1224	423/7206	8.41760189311e-51
ko04724	Glutamatergic synapse	91/1224	152/7206	2.62524227179e-33
ko05032	Morphine addiction	70/1224	110/7206	3.68078242687e-28
ko04713	Circadian entrainment	79/1224	136/7206	9.11436730114e-28
ko05033	Nicotine addiction	46/1224	56/7206	1.15743949661e-26
ko04727	GABAergic synapse	67/1224	110/7206	2.25061432027e-25
ko04725	Cholinergic synapse	78/1224	160/7206	6.28284969604e-21
ko04721	Synaptic vesicle cycle	51/1224	80/7206	7.25248612934e-21
ko04728	Dopaminergic synapse	85/1224	185/7206	1.42663269198e-20
ko04020	Calcium signaling pathway	106/1224	265/7206	1.1110357442e-19
ko04024	cAMP signaling pathway	109/1224	279/7206	2.71190946106e-19
ko04723	Retrograde endocannabinoid signaling	79/1224	175/7206	1.28185873911e-18
ko04911	Insulin secretion	60/1224	117/7206	1.02709540791e-17
ko04726	Serotonergic synapse	63/1224	137/7206	1.47901016256e-15
ko04742	Taste transduction	38/1224	61/7206	2.25004971765e-15
ko04921	Oxytocin signaling pathway	82/1224	209/7206	7.07560308236e-15
ko04970	Salivary secretion	48/1224	95/7206	4.2511392691e-14
ko04261	Adrenergic signaling in cardiomyocytes	74/1224	205/7206	2.10731206962e-11
ko04744	Phototransduction	24/1224	36/7206	4.2419876629e-11
ko04720	Long-term potentiation	44/1224	99/7206	1.21372907483e-10
ko05031	Amphetamine addiction	41/1224	91/7206	3.12632125382e-10
ko03040	Spliceosome	2/1224	145/7206	9.85985530945e-10
ko04925	Aldosterone synthesis and secretion	44/1224	105/7206	1.22519989038e-09
ko03010	Ribosome	1/1224	129/7206	1.53602582321e-09
ko04971	Gastric acid secretion	41/1224	98/7206	4.78228118608e-09
ko04022	cGMP-PKG signaling pathway	70/1224	216/7206	1.82864718188e-08
ko05203	Viral carcinogenesis	16/1224	277/7206	1.93384372544e-08
ko04740	Olfactory transduction	33/1224	80/7206	2.27997395228e-07
ko04972	Pancreatic secretion	41/1224	111/7206	3.3021691937e-07
ko05168	Herpes simplex infection	8/1224	182/7206	3.40264320475e-07
ko03013	RNA transport	7/1224	166/7206	5.70654164483e-07
ko04360	Axon guidance	69/1224	233/7206	1.22549291479e-06
ko05322	Systemic lupus erythematosus	6/1224	151/7206	1.50101564476e-06
ko04540	Gap junction	44/1224	128/7206	2.01931959719e-06
ko04976	Bile secretion	31/1224	80/7206	2.95166983269e-06
ko04966	Collecting duct acid secretion	15/1224	26/7206	3.10242445093e-06
ko04070	Phosphatidylinositol signaling system	39/1224	112/7206	5.03912689513e-06
ko04060	Cytokine-cytokine receptor interaction	11/1224	191/7206	5.14659063544e-06
ko04514	Cell adhesion molecules (CAMs)	43/1224	130/7206	8.26350070475e-06
ko04621	NOD-like receptor signaling pathway	8/1224	157/7206	8.26835563749e-06
ko05164	Influenza A	9/1224	167/7206	8.94458806191e-06
ko04120	Ubiquitin mediated proteolysis	6/1224	138/7206	9.33655387326e-06
ko05030	Cocaine addiction	28/1224	73/7206	1.12223843673e-05
ko04010	MAPK signaling pathway	85/1224	321/7206	1.25549438135e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1224	74/7206	1.45634858015e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1224	122/7206	1.54046422696e-05
ko04924	Renin secretion	31/1224	86/7206	1.69338587014e-05
ko04730	Long-term depression	29/1224	78/7206	2.20220464956e-05
ko05110	Vibrio cholerae infection	25/1224	63/7206	2.25918222972e-05
ko04141	Protein processing in endoplasmic reticulum	12/1224	184/7206	3.70624775918e-05
ko04923	Regulation of lipolysis in adipocytes	28/1224	77/7206	4.13461746054e-05
ko04110	Cell cycle	8/1224	145/7206	4.68477623951e-05
ko04745	Phototransduction - fly	17/1224	38/7206	5.81831916624e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1224	79/7206	6.12770321103e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1224	59/7206	6.18237192805e-05
ko05169	Epstein-Barr virus infection	15/1224	206/7206	6.46681180076e-05
ko05414	Dilated cardiomyopathy	36/1224	112/7206	6.72247643914e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1224	79/7206	0.000110965105412
ko04072	Phospholipase D signaling pathway	54/1224	197/7206	0.000223533717697
ko04260	Cardiac muscle contraction	31/1224	98/7206	0.00033925646971
ko04710	Circadian rhythm	17/1224	43/7206	0.000363765560491
ko04964	Proximal tubule bicarbonate reclamation	13/1224	29/7206	0.000424032820176
ko04014	Ras signaling pathway	70/1224	279/7206	0.00044465676722
ko04612	Antigen processing and presentation	3/1224	77/7206	0.000680798342204
ko04064	NF-kappa B signaling pathway	5/1224	96/7206	0.000873505577357
ko05161	Hepatitis B	14/1224	173/7206	0.000954121571448
ko05140	Leishmaniasis	3/1224	75/7206	0.000990539073966
ko04371	Apelin signaling pathway	47/1224	177/7206	0.00110918665157
ko04330	Notch signaling pathway	2/1224	62/7206	0.0017788214259
ko04915	Estrogen signaling pathway	36/1224	131/7206	0.00215560906195
ko04270	Vascular smooth muscle contraction	41/1224	154/7206	0.0022445294934
ko05166	HTLV-I infection	31/1224	292/7206	0.0024158995355
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1224	100/7206	0.00280520230091
ko04930	Type II diabetes mellitus	18/1224	54/7206	0.0030330876299
ko05162	Measles	9/1224	120/7206	0.00316292255418
ko04217	Necroptosis	16/1224	178/7206	0.00317567247362
ko05205	Proteoglycans in cancer	29/1224	271/7206	0.00383220373715
ko03022	Basal transcription factors	1/1224	44/7206	0.00427403964296
ko05144	Malaria	1/1224	45/7206	0.00434146473578
ko03420	Nucleotide excision repair	1/1224	46/7206	0.00459211317432
ko04626	Plant-pathogen interaction	8/1224	18/7206	0.00595153228101
ko04622	RIG-I-like receptor signaling pathway	3/1224	62/7206	0.00627065565022
ko04630	Jak-STAT signaling pathway	11/1224	132/7206	0.00668205958751
ko00310	Lysine degradation	4/1224	73/7206	0.00687055104039
ko04658	Th1 and Th2 cell differentiation	7/1224	96/7206	0.00876781025923
ko00330	Arginine and proline metabolism	3/1224	61/7206	0.00913940071508
ko04657	IL-17 signaling pathway	6/1224	87/7206	0.00914872982864
ko05133	Pertussis	6/1224	87/7206	0.00914872982864
ko04610	Complement and coagulation cascades	5/1224	79/7206	0.00954864372597
ko04912	GnRH signaling pathway	32/1224	122/7206	0.010056126425
ko05145	Toxoplasmosis	11/1224	126/7206	0.0114416153769
ko05219	Bladder cancer	2/1224	48/7206	0.0118029471534
ko04922	Glucagon signaling pathway	33/1224	128/7206	0.0119939772216
ko04916	Melanogenesis	36/1224	142/7206	0.0124274555959
ko03018	RNA degradation	6/1224	84/7206	0.0124897326408
ko04918	Thyroid hormone synthesis	24/1224	86/7206	0.0130051213634
ko03410	Base excision repair	1/1224	38/7206	0.0149133886616
ko00562	Inositol phosphate metabolism	24/1224	89/7206	0.0154728920833
ko05131	Shigellosis	6/1224	82/7206	0.0171104122741
ko00480	Glutathione metabolism	3/1224	55/7206	0.0182674004005
ko04115	p53 signaling pathway	5/1224	74/7206	0.0182787422233
ko04640	Hematopoietic cell lineage	4/1224	64/7206	0.0183989102591
ko05321	Inflammatory bowel disease (IBD)	3/1224	56/7206	0.0185893266878
ko04960	Aldosterone-regulated sodium reabsorption	13/1224	41/7206	0.0195475032777
ko04210	Apoptosis	19/1224	180/7206	0.0202804531775
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1224	14/7206	0.0207432845431
ko05215	Prostate cancer	10/1224	111/7206	0.0215608100187
ko04146	Peroxisome	7/1224	89/7206	0.0218795853419
ko04973	Carbohydrate digestion and absorption	13/1224	42/7206	0.0223230539669
ko00071	Fatty acid degradation	2/1224	45/7206	0.0258522149393
ko00590	Arachidonic acid metabolism	3/1224	52/7206	0.0258958496942
ko00280	Valine, leucine and isoleucine degradation	3/1224	54/7206	0.0268108760867
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1224	182/7206	0.0276750091791
ko04015	Rap1 signaling pathway	61/1224	278/7206	0.0277993747144
ko00240	Pyrimidine metabolism	10/1224	110/7206	0.0285699760438
ko04620	Toll-like receptor signaling pathway	9/1224	100/7206	0.0313333227354
ko05016	Huntington's disease	25/1224	215/7206	0.0336864296228
ko04978	Mineral absorption	12/1224	40/7206	0.0348084847147
ko00380	Tryptophan metabolism	3/1224	50/7206	0.0365826244054
ko04142	Lysosome	16/1224	151/7206	0.0367603382372
ko04213	Longevity regulating pathway - multiple species	22/1224	86/7206	0.0419165239118
ko05320	Autoimmune thyroid disease	1/1224	29/7206	0.0483956431555
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1224	92/7206	0.0492391613504