ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1312	423/7206	3.94626432978e-51
ko04724	Glutamatergic synapse	93/1312	152/7206	1.39690246754e-32
ko05033	Nicotine addiction	48/1312	56/7206	4.72165335532e-28
ko04713	Circadian entrainment	80/1312	136/7206	1.70313015156e-26
ko05032	Morphine addiction	70/1312	110/7206	3.04004140943e-26
ko04727	GABAergic synapse	69/1312	110/7206	2.45783523952e-25
ko04725	Cholinergic synapse	82/1312	160/7206	9.92489306709e-22
ko04728	Dopaminergic synapse	88/1312	185/7206	2.0153315043e-20
ko04721	Synaptic vesicle cycle	52/1312	80/7206	2.10296168843e-20
ko04020	Calcium signaling pathway	107/1312	265/7206	8.16322273156e-18
ko04024	cAMP signaling pathway	110/1312	279/7206	1.93874905759e-17
ko04723	Retrograde endocannabinoid signaling	79/1312	175/7206	9.03161769037e-17
ko04911	Insulin secretion	60/1312	117/7206	3.19537568058e-16
ko04726	Serotonergic synapse	65/1312	137/7206	2.61897250612e-15
ko04744	Phototransduction	28/1312	36/7206	1.01379226141e-14
ko04742	Taste transduction	38/1312	61/7206	2.35439578544e-14
ko04921	Oxytocin signaling pathway	82/1312	209/7206	4.4565013423e-13
ko04970	Salivary secretion	47/1312	95/7206	3.00957195061e-12
ko04720	Long-term potentiation	48/1312	99/7206	4.5323266828e-12
ko05031	Amphetamine addiction	45/1312	91/7206	8.97121071982e-12
ko04740	Olfactory transduction	41/1312	80/7206	1.75815889971e-11
ko04261	Adrenergic signaling in cardiomyocytes	76/1312	205/7206	8.46436576737e-11
ko03040	Spliceosome	2/1312	145/7206	1.37307424139e-10
ko04360	Axon guidance	80/1312	233/7206	2.2261838692e-09
ko04022	cGMP-PKG signaling pathway	74/1312	216/7206	9.6048930007e-09
ko04925	Aldosterone synthesis and secretion	43/1312	105/7206	5.21635311204e-08
ko03013	RNA transport	7/1312	166/7206	1.11451704869e-07
ko05168	Herpes simplex infection	9/1312	182/7206	1.51475083724e-07
ko04540	Gap junction	48/1312	128/7206	1.8674594963e-07
ko05030	Cocaine addiction	32/1312	73/7206	3.32822860238e-07
ko04621	NOD-like receptor signaling pathway	7/1312	157/7206	3.33429034863e-07
ko04971	Gastric acid secretion	39/1312	98/7206	4.54580794527e-07
ko04730	Long-term depression	33/1312	78/7206	7.37110813952e-07
ko05322	Systemic lupus erythematosus	7/1312	151/7206	1.02311954942e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1312	74/7206	5.86267254207e-06
ko04060	Cytokine-cytokine receptor interaction	13/1312	191/7206	6.40035375443e-06
ko05203	Viral carcinogenesis	24/1312	277/7206	7.47921894914e-06
ko04966	Collecting duct acid secretion	15/1312	26/7206	7.6138436907e-06
ko04972	Pancreatic secretion	40/1312	111/7206	8.70047102403e-06
ko04110	Cell cycle	8/1312	145/7206	1.02542728149e-05
ko04010	MAPK signaling pathway	89/1312	321/7206	1.61554703591e-05
ko04141	Protein processing in endoplasmic reticulum	13/1312	184/7206	1.70260830862e-05
ko04745	Phototransduction - fly	18/1312	38/7206	3.57483995513e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1312	122/7206	4.20249957465e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1312	79/7206	4.5846040069e-05
ko04072	Phospholipase D signaling pathway	59/1312	197/7206	4.79766087844e-05
ko04976	Bile secretion	30/1312	80/7206	5.08465820324e-05
ko04070	Phosphatidylinositol signaling system	38/1312	112/7206	5.88461284613e-05
ko05164	Influenza A	12/1312	167/7206	6.28403784895e-05
ko04514	Cell adhesion molecules (CAMs)	42/1312	130/7206	8.24303203127e-05
ko04014	Ras signaling pathway	77/1312	279/7206	9.44766852449e-05
ko04924	Renin secretion	31/1312	86/7206	9.97126194044e-05
ko04120	Ubiquitin mediated proteolysis	9/1312	138/7206	0.000123270587367
ko04064	NF-kappa B signaling pathway	5/1312	96/7206	0.000273775748892
ko04612	Antigen processing and presentation	3/1312	77/7206	0.000289499190737
ko05414	Dilated cardiomyopathy	36/1312	112/7206	0.000303331829665
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1312	79/7206	0.000316471073602
ko00520	Amino sugar and nucleotide sugar metabolism	1/1312	55/7206	0.000325409574073
ko05169	Epstein-Barr virus infection	19/1312	206/7206	0.00033460772165
ko05140	Leishmaniasis	3/1312	75/7206	0.000426886773701
ko05110	Vibrio cholerae infection	23/1312	63/7206	0.000475596948452
ko04923	Regulation of lipolysis in adipocytes	27/1312	77/7206	0.000477257599213
ko04371	Apelin signaling pathway	51/1312	177/7206	0.000498627672983
ko04915	Estrogen signaling pathway	40/1312	131/7206	0.000534465193051
ko04260	Cardiac muscle contraction	31/1312	98/7206	0.00133370969312
ko04270	Vascular smooth muscle contraction	44/1312	154/7206	0.00142560793178
ko03420	Nucleotide excision repair	1/1312	46/7206	0.00174655531815
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1312	59/7206	0.00178122170271
ko05131	Shigellosis	5/1312	82/7206	0.00228793855593
ko03022	Basal transcription factors	1/1312	44/7206	0.00266239368741
ko00071	Fatty acid degradation	1/1312	45/7206	0.0027952347848
ko04964	Proximal tubule bicarbonate reclamation	12/1312	29/7206	0.00307096330325
ko00310	Lysine degradation	4/1312	73/7206	0.00323127565344
ko04146	Peroxisome	6/1312	89/7206	0.00330525583894
ko05145	Toxoplasmosis	11/1312	126/7206	0.00350110595646
ko05162	Measles	10/1312	120/7206	0.00385173133377
ko00330	Arginine and proline metabolism	3/1312	61/7206	0.00410063313237
ko04622	RIG-I-like receptor signaling pathway	3/1312	62/7206	0.00422842755598
ko04710	Circadian rhythm	16/1312	43/7206	0.00432285058324
ko04657	IL-17 signaling pathway	6/1312	87/7206	0.00464812179512
ko05133	Pertussis	6/1312	87/7206	0.00464812179512
ko05205	Proteoglycans in cancer	32/1312	271/7206	0.00483052133992
ko04922	Glucagon signaling pathway	36/1312	128/7206	0.00526657352515
ko03018	RNA degradation	6/1312	84/7206	0.00632733456405
ko05231	Choline metabolism in cancer	37/1312	134/7206	0.00645013090244
ko04960	Aldosterone-regulated sodium reabsorption	15/1312	41/7206	0.00669054160935
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1312	14/7206	0.00678737312803
ko04930	Type II diabetes mellitus	18/1312	54/7206	0.007060355687
ko04973	Carbohydrate digestion and absorption	15/1312	42/7206	0.00747471623787
ko04217	Necroptosis	19/1312	178/7206	0.00762057813256
ko05214	Glioma	24/1312	79/7206	0.0077807216175
ko05321	Inflammatory bowel disease (IBD)	3/1312	56/7206	0.00850646501438
ko04214	Apoptosis - fly	5/1312	72/7206	0.00889443729327
ko04626	Plant-pathogen interaction	8/1312	18/7206	0.00916485337537
ko00630	Glyoxylate and dicarboxylate metabolism	1/1312	38/7206	0.00955077189827
ko04015	Rap1 signaling pathway	67/1312	278/7206	0.0111619394788
ko04610	Complement and coagulation cascades	6/1312	79/7206	0.0119555125067
ko00240	Pyrimidine metabolism	10/1312	110/7206	0.0120970328354
ko00280	Valine, leucine and isoleucine degradation	3/1312	54/7206	0.0122483314522
ko00860	Porphyrin and chlorophyll metabolism	1/1312	34/7206	0.0138511883183
ko04213	Longevity regulating pathway - multiple species	25/1312	86/7206	0.0157992313771
ko04912	GnRH signaling pathway	33/1312	122/7206	0.0171984884712
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1312	100/7206	0.0178751795902
ko00562	Inositol phosphate metabolism	25/1312	89/7206	0.0187367340836
ko05016	Huntington's disease	26/1312	215/7206	0.0192512935925
ko04916	Melanogenesis	37/1312	142/7206	0.0204213993908
ko05230	Central carbon metabolism in cancer	23/1312	81/7206	0.0206222740943
ko05161	Hepatitis B	20/1312	173/7206	0.0214342474243
ko04115	p53 signaling pathway	6/1312	74/7206	0.0222459771082
ko04658	Th1 and Th2 cell differentiation	9/1312	96/7206	0.0229441819286
ko04918	Thyroid hormone synthesis	24/1312	86/7206	0.0240644793155
ko05166	HTLV-I infection	39/1312	292/7206	0.0298760978392
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1312	182/7206	0.0318322161988
ko03410	Base excision repair	2/1312	38/7206	0.0346693543516
ko05217	Basal cell carcinoma	6/1312	68/7206	0.040654324661
ko04062	Chemokine signaling pathway	48/1312	201/7206	0.0409556756347
ko04113	Meiosis - yeast	6/1312	70/7206	0.0413158298337
ko04142	Lysosome	18/1312	151/7206	0.0427774737559
ko01212	Fatty acid metabolism	5/1312	60/7206	0.0441790394379
ko00590	Arachidonic acid metabolism	4/1312	52/7206	0.0473632834961
ko04722	Neurotrophin signaling pathway	39/1312	160/7206	0.048440290063
ko04152	AMPK signaling pathway	39/1312	161/7206	0.0496830092707