ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 27/394 68/7206 3.00382700582e-17 ko04550 Signaling pathways regulating pluripotency of stem cells 34/394 165/7206 9.07669552907e-12 ko05224 Breast cancer 33/394 174/7206 1.93354373292e-10 ko04974 Protein digestion and absorption 23/394 96/7206 1.05334155553e-09 ko04340 Hedgehog signaling pathway 17/394 58/7206 6.17678728204e-09 ko05200 Pathways in cancer 59/394 492/7206 6.2066769925e-09 ko04390 Hippo signaling pathway 32/394 188/7206 6.23095669675e-09 ko04512 ECM-receptor interaction 19/394 79/7206 2.87843888425e-08 ko05205 Proteoglycans in cancer 38/394 271/7206 5.67982488053e-08 ko04310 Wnt signaling pathway 29/394 181/7206 1.29972503077e-07 ko04950 Maturity onset diabetes of the young 10/394 29/7206 1.67214633125e-06 ko04916 Melanogenesis 23/394 142/7206 2.21203620328e-06 ko04360 Axon guidance 30/394 233/7206 1.05570118714e-05 ko04510 Focal adhesion 30/394 240/7206 1.71992760202e-05 ko04151 PI3K-Akt signaling pathway 42/394 390/7206 1.74018309809e-05 ko05168 Herpes simplex infection 1/394 182/7206 0.000727314153137 ko05203 Viral carcinogenesis 4/394 277/7206 0.00103310460374 ko04350 TGF-beta signaling pathway 14/394 103/7206 0.00134775058221 ko04145 Phagosome 19/394 162/7206 0.00137978011208 ko04062 Chemokine signaling pathway 2/394 201/7206 0.00146296199303 ko04612 Antigen processing and presentation 11/394 77/7206 0.00290423396157 ko05222 Small cell lung cancer 12/394 89/7206 0.00312388368883 ko04724 Glutamatergic synapse 1/394 152/7206 0.00329359512288 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/394 182/7206 0.00433360044119 ko04921 Oxytocin signaling pathway 3/394 209/7206 0.0049542173099 ko05034 Alcoholism 4/394 238/7206 0.00534700851305 ko04080 Neuroactive ligand-receptor interaction 11/394 423/7206 0.00553362035768 ko04330 Notch signaling pathway 9/394 62/7206 0.00613657783166 ko04723 Retrograde endocannabinoid signaling 2/394 175/7206 0.00619348936149 ko04114 Oocyte meiosis 1/394 139/7206 0.00708684744225 ko05166 HTLV-I infection 27/394 292/7206 0.00784370665555 ko05202 Transcriptional misregulation in cancer 19/394 188/7206 0.00851074908201 ko05410 Hypertrophic cardiomyopathy (HCM) 12/394 100/7206 0.0115320883723 ko04071 Sphingolipid signaling pathway 2/394 162/7206 0.0127287184486 ko04144 Endocytosis 9/394 342/7206 0.0144184927796 ko00190 Oxidative phosphorylation 1/394 127/7206 0.0155342805845 ko04391 Hippo signaling pathway - fly 11/394 90/7206 0.01573503788 ko04341 Hedgehog signaling pathway - fly 6/394 38/7206 0.0160406510403 ko05322 Systemic lupus erythematosus 2/394 151/7206 0.0173995351081 ko05414 Dilated cardiomyopathy 12/394 112/7206 0.0206245565112 ko00670 One carbon pool by folate 4/394 20/7206 0.021226715995 ko04260 Cardiac muscle contraction 11/394 98/7206 0.0214260842794 ko00514 Other types of O-glycan biosynthesis 5/394 30/7206 0.0219014591135 ko05218 Melanoma 10/394 85/7206 0.0251626287268 ko04072 Phospholipase D signaling pathway 4/394 197/7206 0.0256043095294 ko04910 Insulin signaling pathway 3/394 172/7206 0.025814624826 ko05206 MicroRNAs in cancer 17/394 177/7206 0.0271269217026 ko04210 Apoptosis 17/394 180/7206 0.0285275228834 ko04977 Vitamin digestion and absorption 4/394 22/7206 0.0294160058013 ko00970 Aminoacyl-tRNA biosynthesis 6/394 44/7206 0.0312144803547 ko00240 Pyrimidine metabolism 1/394 110/7206 0.0312149578269 ko00350 Tyrosine metabolism 5/394 33/7206 0.0319326411835 ko04070 Phosphatidylinositol signaling system 1/394 112/7206 0.032150497737 ko04713 Circadian entrainment 2/394 136/7206 0.0343997662764 ko04611 Platelet activation 3/394 163/7206 0.0353167982172 ko05216 Thyroid cancer 5/394 34/7206 0.0358199969757 ko05130 Pathogenic Escherichia coli infection 9/394 77/7206 0.036715330523 ko04020 Calcium signaling pathway 7/394 265/7206 0.0379707938694 ko04975 Fat digestion and absorption 5/394 35/7206 0.0399867090386 ko04620 Toll-like receptor signaling pathway 1/394 100/7206 0.0439738146711 ko01200 Carbon metabolism 2/394 128/7206 0.048026326426 ko03010 Ribosome 2/394 129/7206 0.0482515735201 ko05142 Chagas disease (American trypanosomiasis) 2/394 130/7206 0.0485778959152 ko04621 NOD-like receptor signaling pathway 3/394 157/7206 0.048698460087