ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 145/732 423/7206 1.17850390018e-44 ko04724 Glutamatergic synapse 63/732 152/7206 1.58241449679e-24 ko05033 Nicotine addiction 37/732 56/7206 5.01149649363e-24 ko04721 Synaptic vesicle cycle 44/732 80/7206 1.25738130764e-23 ko04727 GABAergic synapse 46/732 110/7206 2.29786542811e-18 ko05032 Morphine addiction 45/732 110/7206 1.52739311039e-17 ko04728 Dopaminergic synapse 57/732 185/7206 3.0458480679e-15 ko04723 Retrograde endocannabinoid signaling 53/732 175/7206 6.59107442479e-14 ko04713 Circadian entrainment 45/732 136/7206 1.62904304096e-13 ko04024 cAMP signaling pathway 65/732 279/7206 8.79561845411e-11 ko04725 Cholinergic synapse 45/732 160/7206 8.94448061387e-11 ko04742 Taste transduction 25/732 61/7206 2.50590126285e-10 ko04020 Calcium signaling pathway 61/732 265/7206 5.18371301873e-10 ko04726 Serotonergic synapse 39/732 137/7206 1.12825871935e-09 ko04911 Insulin secretion 35/732 117/7206 1.91552788384e-09 ko05031 Amphetamine addiction 29/732 91/7206 9.68793217247e-09 ko04744 Phototransduction 17/732 36/7206 1.46160204776e-08 ko04921 Oxytocin signaling pathway 48/732 209/7206 3.65394470304e-08 ko04261 Adrenergic signaling in cardiomyocytes 47/732 205/7206 5.41574824152e-08 ko05030 Cocaine addiction 24/732 73/7206 9.45499344092e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 24/732 74/7206 1.26738254885e-07 ko04966 Collecting duct acid secretion 13/732 26/7206 3.27582563263e-07 ko03040 Spliceosome 1/732 145/7206 4.80196718272e-06 ko05203 Viral carcinogenesis 8/732 277/7206 5.80035362303e-06 ko04120 Ubiquitin mediated proteolysis 1/732 138/7206 1.09267711876e-05 ko05322 Systemic lupus erythematosus 2/732 151/7206 2.81427266496e-05 ko05110 Vibrio cholerae infection 18/732 63/7206 3.39758564364e-05 ko05164 Influenza A 3/732 167/7206 4.03244081189e-05 ko04514 Cell adhesion molecules (CAMs) 29/732 130/7206 4.47766830885e-05 ko05168 Herpes simplex infection 4/732 182/7206 5.11829571385e-05 ko04720 Long-term potentiation 24/732 99/7206 5.9988283435e-05 ko04621 NOD-like receptor signaling pathway 3/732 157/7206 8.18643593711e-05 ko05205 Proteoglycans in cancer 10/732 271/7206 8.50299183291e-05 ko04060 Cytokine-cytokine receptor interaction 5/732 191/7206 8.57847105105e-05 ko04970 Salivary secretion 23/732 95/7206 9.02152916818e-05 ko04010 MAPK signaling pathway 55/732 321/7206 9.03644168133e-05 ko04260 Cardiac muscle contraction 22/732 98/7206 0.000283317660427 ko05162 Measles 2/732 120/7206 0.000602264853207 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/732 79/7206 0.00096095665478 ko03013 RNA transport 5/732 166/7206 0.000969491548011 ko04360 Axon guidance 39/732 233/7206 0.00182571834292 ko04141 Protein processing in endoplasmic reticulum 7/732 184/7206 0.00187500599317 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/732 59/7206 0.00189446613171 ko04730 Long-term depression 17/732 78/7206 0.00199974723832 ko04972 Pancreatic secretion 22/732 111/7206 0.00212903994436 ko04510 Focal adhesion 11/732 240/7206 0.00218793106482 ko04540 Gap junction 24/732 128/7206 0.00275918076914 ko04924 Renin secretion 18/732 86/7206 0.00315811099367 ko05169 Epstein-Barr virus infection 9/732 206/7206 0.00323196301128 ko04612 Antigen processing and presentation 1/732 77/7206 0.00398078420753 ko04610 Complement and coagulation cascades 1/732 79/7206 0.00407438596594 ko03008 Ribosome biogenesis in eukaryotes 1/732 79/7206 0.00407438596594 ko04925 Aldosterone synthesis and secretion 20/732 105/7206 0.00502550905522 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/732 92/7206 0.00517031158177 ko05166 HTLV-I infection 16/732 292/7206 0.00538399538763 ko04971 Gastric acid secretion 19/732 98/7206 0.00597388326993 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/732 182/7206 0.00602718823475 ko04964 Proximal tubule bicarbonate reclamation 8/732 29/7206 0.00674709904706 ko04146 Peroxisome 2/732 89/7206 0.00743135901856 ko04072 Phospholipase D signaling pathway 32/732 197/7206 0.00793967092671 ko04022 cGMP-PKG signaling pathway 34/732 216/7206 0.00835232958821 ko04611 Platelet activation 7/732 163/7206 0.00844138506072 ko04214 Apoptosis - fly 1/732 72/7206 0.00904818526794 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/732 14/7206 0.00978290788757 ko05161 Hepatitis B 8/732 173/7206 0.0106644596702 ko05414 Dilated cardiomyopathy 20/732 112/7206 0.0108781021526 ko05323 Rheumatoid arthritis 17/732 89/7206 0.0116926920052 ko05146 Amoebiasis 3/732 99/7206 0.0117348895926 ko04110 Cell cycle 6/732 145/7206 0.0118383499193 ko04064 NF-kappa B signaling pathway 3/732 96/7206 0.0164154541471 ko04145 Phagosome 26/732 162/7206 0.017197990764 ko00330 Arginine and proline metabolism 1/732 61/7206 0.0184684624594 ko01524 Platinum drug resistance 2/732 76/7206 0.0216024211822 ko04976 Bile secretion 15/732 80/7206 0.0229213551031 ko04140 Autophagy - animal 8/732 164/7206 0.0250081209091 ko04630 Jak-STAT signaling pathway 6/732 132/7206 0.0284047347235 ko05410 Hypertrophic cardiomyopathy (HCM) 17/732 100/7206 0.0293983029381 ko04626 Plant-pathogen interaction 5/732 18/7206 0.0297727449685 ko05200 Pathways in cancer 36/732 492/7206 0.030218204176 ko04668 TNF signaling pathway 5/732 120/7206 0.0310388544246 ko04350 TGF-beta signaling pathway 4/732 103/7206 0.0314612599312 ko05140 Leishmaniasis 2/732 75/7206 0.0316784189857 ko04740 Olfactory transduction 14/732 80/7206 0.038621530082 ko00480 Glutathione metabolism 1/732 55/7206 0.0401801215358 ko05321 Inflammatory bowel disease (IBD) 1/732 56/7206 0.0412127985521 ko03018 RNA degradation 3/732 84/7206 0.0440715609544 ko04962 Vasopressin-regulated water reabsorption 11/732 58/7206 0.0445074450202 ko05220 Chronic myeloid leukemia 3/732 85/7206 0.0445423967758