ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 31/254 167/7206 1.09856818416e-14 ko04380 Osteoclast differentiation 26/254 134/7206 6.00036220979e-13 ko04620 Toll-like receptor signaling pathway 21/254 100/7206 2.30163652981e-11 ko04621 NOD-like receptor signaling pathway 26/254 157/7206 2.68360862779e-11 ko05161 Hepatitis B 27/254 173/7206 4.52587966206e-11 ko05162 Measles 22/254 120/7206 1.27291382885e-10 ko04630 Jak-STAT signaling pathway 23/254 132/7206 1.38755202304e-10 ko05140 Leishmaniasis 17/254 75/7206 5.58313653883e-10 ko04060 Cytokine-cytokine receptor interaction 26/254 191/7206 2.26864965237e-09 ko05321 Inflammatory bowel disease (IBD) 14/254 56/7206 4.94209417769e-09 ko04668 TNF signaling pathway 20/254 120/7206 5.22672510228e-09 ko05152 Tuberculosis 25/254 187/7206 6.86858961392e-09 ko04660 T cell receptor signaling pathway 20/254 124/7206 9.3953952136e-09 ko05145 Toxoplasmosis 20/254 126/7206 1.24795963656e-08 ko04658 Th1 and Th2 cell differentiation 17/254 96/7206 3.01518237718e-08 ko04064 NF-kappa B signaling pathway 17/254 96/7206 3.01518237718e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/254 191/7206 4.77373327622e-08 ko05168 Herpes simplex infection 23/254 182/7206 8.29284842442e-08 ko04659 Th17 cell differentiation 17/254 106/7206 1.37601831777e-07 ko05323 Rheumatoid arthritis 15/254 89/7206 3.93570242177e-07 ko04650 Natural killer cell mediated cytotoxicity 15/254 97/7206 1.23925219393e-06 ko05133 Pertussis 14/254 87/7206 1.72989457306e-06 ko05142 Chagas disease (American trypanosomiasis) 17/254 130/7206 2.68595721599e-06 ko04672 Intestinal immune network for IgA production 9/254 37/7206 3.81679914905e-06 ko04933 AGE-RAGE signaling pathway in diabetic complications 17/254 135/7206 4.54311929424e-06 ko04210 Apoptosis 20/254 180/7206 4.64352455546e-06 ko05340 Primary immunodeficiency 8/254 30/7206 6.3673122184e-06 ko04623 Cytosolic DNA-sensing pathway 9/254 41/7206 9.49858920333e-06 ko04662 B cell receptor signaling pathway 13/254 88/7206 1.08128360583e-05 ko05144 Malaria 9/254 45/7206 2.12340246396e-05 ko05160 Hepatitis C 17/254 153/7206 2.45354519347e-05 ko05150 Staphylococcus aureus infection 8/254 36/7206 2.7394144267e-05 ko05132 Salmonella infection 13/254 98/7206 3.53421681656e-05 ko04917 Prolactin signaling pathway 12/254 87/7206 4.78375232982e-05 ko04217 Necroptosis 18/254 178/7206 5.07008397978e-05 ko04622 RIG-I-like receptor signaling pathway 10/254 62/7206 5.29109192787e-05 ko04610 Complement and coagulation cascades 11/254 79/7206 9.06987128245e-05 ko05166 HTLV-I infection 24/254 292/7206 0.000111116780573 ko05320 Autoimmune thyroid disease 6/254 29/7206 0.000433590499897 ko05330 Allograft rejection 5/254 24/7206 0.00128215492986 ko04612 Antigen processing and presentation 9/254 77/7206 0.00144626292262 ko05169 Epstein-Barr virus infection 17/254 206/7206 0.00147349417299 ko05310 Asthma 4/254 17/7206 0.00249606272883 ko04062 Chemokine signaling pathway 16/254 201/7206 0.00255352057454 ko05416 Viral myocarditis 7/254 55/7206 0.00297339225408 ko04657 IL-17 signaling pathway 9/254 87/7206 0.0033890382424 ko04666 Fc gamma R-mediated phagocytosis 11/254 122/7206 0.00371111982967 ko05134 Legionellosis 8/254 74/7206 0.00430165876442 ko04664 Fc epsilon RI signaling pathway 8/254 77/7206 0.00548694168331 ko04611 Platelet activation 13/254 163/7206 0.00754453682403 ko05146 Amoebiasis 9/254 99/7206 0.00794248503861 ko05131 Shigellosis 8/254 82/7206 0.00799692155495 ko04137 Mitophagy - animal 8/254 82/7206 0.00799692155495 ko04931 Insulin resistance 11/254 137/7206 0.00882139500638 ko04920 Adipocytokine signaling pathway 8/254 89/7206 0.0128472403149 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/254 182/7206 0.0132247847264 ko04080 Neuroactive ligand-receptor interaction 6/254 423/7206 0.0134670128893 ko05332 Graft-versus-host disease 3/254 18/7206 0.023863820362 ko04514 Cell adhesion molecules (CAMs) 10/254 130/7206 0.0252299181603 ko05212 Pancreatic cancer 7/254 83/7206 0.0265677835668 ko04072 Phospholipase D signaling pathway 13/254 197/7206 0.0281286850054 ko04624 Toll and Imd signaling pathway 5/254 49/7206 0.0282214631792 ko05220 Chronic myeloid leukemia 7/254 85/7206 0.0297858771469 ko03013 RNA transport 1/254 166/7206 0.0314730238776 ko05210 Colorectal cancer 7/254 86/7206 0.0314895060171 ko05016 Huntington's disease 2/254 215/7206 0.0359467392269 ko04930 Type II diabetes mellitus 5/254 54/7206 0.0406772610921 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/254 92/7206 0.0430878316298 ko05012 Parkinson's disease 1/254 155/7206 0.0452785425983 ko04115 p53 signaling pathway 6/254 74/7206 0.0455962399479 ko05034 Alcoholism 3/254 238/7206 0.0492137589053 ko05010 Alzheimer's disease 2/254 202/7206 0.0498045725825