ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	33/589	56/7206	2.91042632261e-22
ko04727	GABAergic synapse	43/589	110/7206	1.60108051801e-19
ko04724	Glutamatergic synapse	51/589	152/7206	1.6462807622e-19
ko05032	Morphine addiction	42/589	110/7206	1.21944156827e-18
ko04721	Synaptic vesicle cycle	34/589	80/7206	5.18663775866e-17
ko04744	Phototransduction	23/589	36/7206	5.40104302432e-17
ko04723	Retrograde endocannabinoid signaling	50/589	175/7206	7.35419083254e-16
ko04713	Circadian entrainment	39/589	136/7206	1.12776287147e-12
ko04728	Dopaminergic synapse	46/589	185/7206	2.84996206373e-12
ko04080	Neuroactive ligand-receptor interaction	77/589	423/7206	6.30204160516e-12
ko04911	Insulin secretion	33/589	117/7206	1.05886954438e-10
ko04725	Cholinergic synapse	39/589	160/7206	2.63105426117e-10
ko04024	cAMP signaling pathway	52/589	279/7206	9.63245806758e-09
ko04261	Adrenergic signaling in cardiomyocytes	40/589	205/7206	1.5824766479e-07
ko04726	Serotonergic synapse	29/589	137/7206	1.34581264855e-06
ko05203	Viral carcinogenesis	4/589	277/7206	1.57682445621e-06
ko05030	Cocaine addiction	19/589	73/7206	3.88092101622e-06
ko04970	Salivary secretion	22/589	95/7206	5.54588632923e-06
ko04514	Cell adhesion molecules (CAMs)	26/589	130/7206	1.40234432733e-05
ko05164	Influenza A	1/589	167/7206	1.95493654928e-05
ko04921	Oxytocin signaling pathway	35/589	209/7206	4.87812091051e-05
ko05205	Proteoglycans in cancer	6/589	271/7206	5.81007985961e-05
ko05322	Systemic lupus erythematosus	1/589	151/7206	6.16707392256e-05
ko04742	Taste transduction	15/589	61/7206	8.2731608643e-05
ko03040	Spliceosome	1/589	145/7206	9.02600915491e-05
ko04966	Collecting duct acid secretion	9/589	26/7206	0.000134732436223
ko04060	Cytokine-cytokine receptor interaction	3/589	191/7206	0.000135208481523
ko04120	Ubiquitin mediated proteolysis	1/589	138/7206	0.000207203688519
ko05168	Herpes simplex infection	3/589	182/7206	0.000282370033984
ko04260	Cardiac muscle contraction	19/589	98/7206	0.000303506678267
ko04964	Proximal tubule bicarbonate reclamation	9/589	29/7206	0.000345632752834
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/589	14/7206	0.00049353551364
ko04010	MAPK signaling pathway	44/589	321/7206	0.000534302188096
ko05161	Hepatitis B	3/589	173/7206	0.00058890450309
ko04972	Pancreatic secretion	20/589	111/7206	0.000652256859429
ko05014	Amyotrophic lateral sclerosis (ALS)	15/589	74/7206	0.000790121604875
ko03013	RNA transport	3/589	166/7206	0.000808957843464
ko05215	Prostate cancer	1/589	111/7206	0.00137382179576
ko05166	HTLV-I infection	10/589	292/7206	0.00141670526449
ko04630	Jak-STAT signaling pathway	2/589	132/7206	0.00192481546375
ko04720	Long-term potentiation	17/589	99/7206	0.00271669617236
ko05169	Epstein-Barr virus infection	6/589	206/7206	0.00276238257099
ko04976	Bile secretion	15/589	80/7206	0.00286636282414
ko05031	Amphetamine addiction	16/589	91/7206	0.00300398394712
ko04022	cGMP-PKG signaling pathway	30/589	216/7206	0.00350025887568
ko04140	Autophagy - animal	4/589	164/7206	0.00355876722649
ko04510	Focal adhesion	8/589	240/7206	0.00368066057672
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/589	182/7206	0.00371312332767
ko04668	TNF signaling pathway	2/589	120/7206	0.00390887856428
ko04660	T cell receptor signaling pathway	2/589	124/7206	0.00412527940562
ko04978	Mineral absorption	9/589	40/7206	0.00419318466062
ko05110	Vibrio cholerae infection	12/589	63/7206	0.00442758614263
ko04730	Long-term depression	14/589	78/7206	0.00512375347966
ko04810	Regulation of actin cytoskeleton	10/589	264/7206	0.00571209947365
ko05418	Fluid shear stress and atherosclerosis	5/589	173/7206	0.00701892538517
ko04020	Calcium signaling pathway	34/589	265/7206	0.00811949159313
ko04068	FoxO signaling pathway	5/589	167/7206	0.00951467028722
ko04110	Cell cycle	4/589	145/7206	0.0131598581994
ko05220	Chronic myeloid leukemia	1/589	85/7206	0.0143815268298
ko04971	Gastric acid secretion	15/589	98/7206	0.0149673024456
ko04620	Toll-like receptor signaling pathway	2/589	100/7206	0.0161438005544
ko04925	Aldosterone synthesis and secretion	16/589	105/7206	0.0174170906875
ko04621	NOD-like receptor signaling pathway	5/589	157/7206	0.0175292810258
ko01524	Platinum drug resistance	1/589	76/7206	0.0196223462437
ko05211	Renal cell carcinoma	2/589	96/7206	0.0229580765569
ko00564	Glycerophospholipid metabolism	2/589	99/7206	0.0240167655853
ko04961	Endocrine and other factor-regulated calcium reabsorption	10/589	59/7206	0.0264508035528
ko04924	Renin secretion	13/589	86/7206	0.027108042259
ko04918	Thyroid hormone synthesis	13/589	86/7206	0.027108042259
ko04141	Protein processing in endoplasmic reticulum	7/589	184/7206	0.0279876843145
ko04214	Apoptosis - fly	1/589	72/7206	0.0286379642652
ko04745	Phototransduction - fly	7/589	38/7206	0.032015547572
ko04146	Peroxisome	2/589	89/7206	0.032291638802
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	12/589	79/7206	0.0350944107571
ko04974	Protein digestion and absorption	14/589	96/7206	0.0357129351777
ko00290	Valine, leucine and isoleucine biosynthesis	2/589	4/7206	0.0358079175912
ko04218	Cellular senescence	7/589	177/7206	0.0363810497676
ko04740	Olfactory transduction	12/589	80/7206	0.0368170080177
ko04210	Apoptosis	7/589	180/7206	0.0371377197478
ko04657	IL-17 signaling pathway	2/589	87/7206	0.0460763614961
ko05133	Pertussis	2/589	87/7206	0.0460763614961
ko01521	EGFR tyrosine kinase inhibitor resistance	3/589	106/7206	0.0467767764629
ko05224	Breast cancer	7/589	174/7206	0.0481463412845
ko04371	Apelin signaling pathway	22/589	177/7206	0.0499046961528