ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 53/534 152/7206 3.8939747436e-23 ko05032 Morphine addiction 40/534 110/7206 1.89607910975e-18 ko05033 Nicotine addiction 28/534 56/7206 1.23476530909e-17 ko04727 GABAergic synapse 39/534 110/7206 1.4333836563e-17 ko04723 Retrograde endocannabinoid signaling 49/534 175/7206 6.49420252786e-17 ko04721 Synaptic vesicle cycle 32/534 80/7206 2.12365924243e-16 ko04713 Circadian entrainment 42/534 136/7206 2.50287699506e-16 ko04080 Neuroactive ligand-receptor interaction 80/534 423/7206 8.95743394921e-16 ko04728 Dopaminergic synapse 46/534 185/7206 8.00358183664e-14 ko04744 Phototransduction 19/534 36/7206 6.46850139924e-13 ko04726 Serotonergic synapse 37/534 137/7206 1.63697828421e-12 ko04911 Insulin secretion 31/534 117/7206 1.88041400064e-10 ko04024 cAMP signaling pathway 52/534 279/7206 2.70180858372e-10 ko04725 Cholinergic synapse 36/534 160/7206 9.28840897499e-10 ko04921 Oxytocin signaling pathway 37/534 209/7206 5.27754242588e-07 ko04261 Adrenergic signaling in cardiomyocytes 36/534 205/7206 8.97428831625e-07 ko05031 Amphetamine addiction 21/534 91/7206 2.03312188704e-06 ko05030 Cocaine addiction 18/534 73/7206 4.01179001652e-06 ko04970 Salivary secretion 21/534 95/7206 4.24687975939e-06 ko04720 Long-term potentiation 21/534 99/7206 8.46258778635e-06 ko04060 Cytokine-cytokine receptor interaction 1/534 191/7206 8.91106954782e-06 ko04020 Calcium signaling pathway 40/534 265/7206 1.180499193e-05 ko04010 MAPK signaling pathway 45/534 321/7206 2.60461281124e-05 ko04966 Collecting duct acid secretion 9/534 26/7206 6.27168684485e-05 ko04730 Long-term depression 16/534 78/7206 0.000151748358346 ko05203 Viral carcinogenesis 6/534 277/7206 0.000156637701829 ko04972 Pancreatic secretion 20/534 111/7206 0.000159365679176 ko05110 Vibrio cholerae infection 14/534 63/7206 0.000159801306133 ko05322 Systemic lupus erythematosus 1/534 151/7206 0.00021107992163 ko04925 Aldosterone synthesis and secretion 19/534 105/7206 0.000218276492894 ko04260 Cardiac muscle contraction 18/534 98/7206 0.000262197625182 ko03040 Spliceosome 1/534 145/7206 0.000307881147296 ko04742 Taste transduction 13/534 61/7206 0.000421878336534 ko04120 Ubiquitin mediated proteolysis 1/534 138/7206 0.000447667427414 ko05164 Influenza A 2/534 167/7206 0.000458670269387 ko04514 Cell adhesion molecules (CAMs) 21/534 130/7206 0.000565205207829 ko04022 cGMP-PKG signaling pathway 29/534 216/7206 0.00144302100362 ko04745 Phototransduction - fly 9/534 38/7206 0.00146724965323 ko04070 Phosphatidylinositol signaling system 18/534 112/7206 0.00153468255646 ko04072 Phospholipase D signaling pathway 27/534 197/7206 0.00204482966923 ko05162 Measles 1/534 120/7206 0.00218774369545 ko04971 Gastric acid secretion 16/534 98/7206 0.00260016181912 ko05014 Amyotrophic lateral sclerosis (ALS) 13/534 74/7206 0.0027681913145 ko05169 Epstein-Barr virus infection 5/534 206/7206 0.00276950470903 ko05205 Proteoglycans in cancer 8/534 271/7206 0.00282681432587 ko04014 Ras signaling pathway 34/534 279/7206 0.00339671110291 ko05120 Epithelial cell signaling in Helicobacter pylori infection 15/534 92/7206 0.0036985023268 ko04350 TGF-beta signaling pathway 1/534 103/7206 0.00670311827232 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 13/534 79/7206 0.0071752143675 ko04740 Olfactory transduction 13/534 80/7206 0.00758520212167 ko04960 Aldosterone-regulated sodium reabsorption 8/534 41/7206 0.00930963473816 ko04110 Cell cycle 3/534 145/7206 0.00934882030947 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/534 59/7206 0.0106125434282 ko04924 Renin secretion 13/534 86/7206 0.0114821147621 ko04510 Focal adhesion 8/534 240/7206 0.0115737194629 ko05166 HTLV-I infection 11/534 292/7206 0.011853622731 ko05168 Herpes simplex infection 5/534 182/7206 0.0136585132441 ko04540 Gap junction 17/534 128/7206 0.0161947325454 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/534 14/7206 0.0164036758315 ko05215 Prostate cancer 2/534 111/7206 0.0165348456647 ko04964 Proximal tubule bicarbonate reclamation 6/534 29/7206 0.0176351989295 ko04810 Regulation of actin cytoskeleton 10/534 264/7206 0.0220125145398 ko04750 Inflammatory mediator regulation of TRP channels 16/534 122/7206 0.0222022892467 ko03013 RNA transport 5/534 166/7206 0.0239381517785 ko04550 Signaling pathways regulating pluripotency of stem cells 5/534 165/7206 0.0239390054314 ko04978 Mineral absorption 7/534 40/7206 0.0258423688016 ko04610 Complement and coagulation cascades 1/534 79/7206 0.0291352481898 ko03008 Ribosome biogenesis in eukaryotes 1/534 79/7206 0.0291352481898 ko04141 Protein processing in endoplasmic reticulum 6/534 184/7206 0.0308782739425 ko05323 Rheumatoid arthritis 12/534 89/7206 0.0387805348457 ko04626 Plant-pathogen interaction 4/534 18/7206 0.0396438510163 ko04218 Cellular senescence 6/534 177/7206 0.0403696868688 ko00310 Lysine degradation 1/534 73/7206 0.0420707274006 ko05140 Leishmaniasis 1/534 75/7206 0.0427102787215 ko05034 Alcoholism 26/534 238/7206 0.0431183947624 ko04621 NOD-like receptor signaling pathway 5/534 157/7206 0.0433662950245