ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	87/667	145/7206	6.99499615486e-54
ko03013	RNA transport	71/667	166/7206	3.40215882265e-31
ko04110	Cell cycle	65/667	145/7206	4.49159288731e-30
ko03008	Ribosome biogenesis in eukaryotes	45/667	79/7206	9.55355684375e-27
ko03030	DNA replication	31/667	38/7206	3.22132983428e-26
ko04111	Cell cycle - yeast	45/667	90/7206	1.46912308757e-23
ko03440	Homologous recombination	26/667	41/7206	1.40990003548e-17
ko00240	Pyrimidine metabolism	43/667	110/7206	1.86867157973e-17
ko04080	Neuroactive ligand-receptor interaction	1/667	423/7206	2.72257866933e-17
ko03430	Mismatch repair	18/667	22/7206	1.03134334913e-15
ko03460	Fanconi anemia pathway	26/667	51/7206	2.24336173057e-14
ko04113	Meiosis - yeast	30/667	70/7206	8.194850241e-14
ko03050	Proteasome	25/667	54/7206	1.18970091523e-12
ko04144	Endocytosis	2/667	342/7206	2.17059669413e-12
ko03020	RNA polymerase	18/667	29/7206	2.6101421522e-12
ko03420	Nucleotide excision repair	22/667	46/7206	1.21672207459e-11
ko03410	Base excision repair	19/667	38/7206	1.17586124607e-10
ko03015	mRNA surveillance pathway	29/667	93/7206	1.98398581938e-09
ko00230	Purine metabolism	45/667	194/7206	3.73426725048e-09
ko04024	cAMP signaling pathway	3/667	279/7206	9.51799676406e-09
ko04810	Regulation of actin cytoskeleton	3/667	264/7206	2.99965827283e-08
ko05010	Alzheimer's disease	1/667	202/7206	9.21811371495e-08
ko04022	cGMP-PKG signaling pathway	2/667	216/7206	2.7537480991e-07
ko03018	RNA degradation	24/667	84/7206	3.14721255452e-07
ko04510	Focal adhesion	3/667	240/7206	3.18530166241e-07
ko04060	Cytokine-cytokine receptor interaction	1/667	191/7206	3.30824545229e-07
ko04371	Apelin signaling pathway	1/667	177/7206	1.06548154034e-06
ko05169	Epstein-Barr virus infection	41/667	206/7206	1.94692249107e-06
ko04072	Phospholipase D signaling pathway	2/667	197/7206	2.10194339576e-06
ko04261	Adrenergic signaling in cardiomyocytes	3/667	205/7206	6.68041645616e-06
ko04014	Ras signaling pathway	7/667	279/7206	7.5326149315e-06
ko04062	Chemokine signaling pathway	3/667	201/7206	9.82547366258e-06
ko04724	Glutamatergic synapse	1/667	152/7206	1.2088779314e-05
ko04910	Insulin signaling pathway	2/667	172/7206	1.35441295212e-05
ko04151	PI3K-Akt signaling pathway	14/667	390/7206	1.37720460349e-05
ko04723	Retrograde endocannabinoid signaling	2/667	175/7206	1.43730207077e-05
ko04360	Axon guidance	5/667	233/7206	1.57785610965e-05
ko04010	MAPK signaling pathway	10/667	321/7206	1.83521467828e-05
ko04611	Platelet activation	2/667	163/7206	2.91735210189e-05
ko04015	Rap1 signaling pathway	8/667	278/7206	3.17937302459e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	3/667	182/7206	4.21265895227e-05
ko04725	Cholinergic synapse	2/667	160/7206	4.31255613865e-05
ko05012	Parkinson's disease	2/667	155/7206	6.26835233448e-05
ko04621	NOD-like receptor signaling pathway	2/667	157/7206	6.49731729701e-05
ko04915	Estrogen signaling pathway	1/667	131/7206	8.94018718377e-05
ko04728	Dopaminergic synapse	4/667	185/7206	0.000155824794452
ko04931	Insulin resistance	2/667	137/7206	0.000283108396574
ko04726	Serotonergic synapse	2/667	137/7206	0.000283108396574
ko04972	Pancreatic secretion	1/667	111/7206	0.000404429994167
ko04727	GABAergic synapse	1/667	110/7206	0.000404783932452
ko05032	Morphine addiction	1/667	110/7206	0.000404783932452
ko04070	Phosphatidylinositol signaling system	1/667	112/7206	0.000408969235722
ko04630	Jak-STAT signaling pathway	2/667	132/7206	0.000411942993883
ko04713	Circadian entrainment	2/667	136/7206	0.000437658188193
ko05152	Tuberculosis	5/667	187/7206	0.000498823824887
ko04114	Oocyte meiosis	26/667	139/7206	0.000505517799972
ko04670	Leukocyte transendothelial migration	3/667	151/7206	0.000535879008991
ko05166	HTLV-I infection	45/667	292/7206	0.000593329443306
ko04659	Th17 cell differentiation	1/667	106/7206	0.000597311412388
ko01521	EGFR tyrosine kinase inhibitor resistance	1/667	106/7206	0.000597311412388
ko05142	Chagas disease (American trypanosomiasis)	2/667	130/7206	0.000607716590723
ko04012	ErbB signaling pathway	1/667	109/7206	0.000624406611046
ko04071	Sphingolipid signaling pathway	4/667	162/7206	0.000882900085421
ko05145	Toxoplasmosis	2/667	126/7206	0.000887205561126
ko04120	Ubiquitin mediated proteolysis	25/667	138/7206	0.000922274653084
ko04530	Tight junction	8/667	228/7206	0.0010512196906
ko04666	Fc gamma R-mediated phagocytosis	2/667	122/7206	0.00129463267789
ko04720	Long-term potentiation	1/667	99/7206	0.00131495542197
ko04066	HIF-1 signaling pathway	2/667	123/7206	0.00133396439144
ko03450	Non-homologous end-joining	6/667	15/7206	0.00148272651518
ko04914	Progesterone-mediated oocyte maturation	20/667	104/7206	0.00162585188466
ko03022	Basal transcription factors	11/667	44/7206	0.00175623666906
ko04911	Insulin secretion	2/667	117/7206	0.00184318021924
ko04380	Osteoclast differentiation	3/667	134/7206	0.00222633300867
ko04933	AGE-RAGE signaling pathway in diabetic complications	3/667	135/7206	0.00227468057096
ko00562	Inositol phosphate metabolism	1/667	89/7206	0.00281735976968
ko05031	Amphetamine addiction	1/667	91/7206	0.00288620384953
ko04922	Glucagon signaling pathway	3/667	128/7206	0.00309574038851
ko03010	Ribosome	3/667	129/7206	0.00312513827663
ko04152	AMPK signaling pathway	5/667	161/7206	0.00356935921415
ko04217	Necroptosis	6/667	178/7206	0.00363324983118
ko04924	Renin secretion	1/667	86/7206	0.00418656768074
ko05133	Pertussis	1/667	87/7206	0.00427472518878
ko04218	Cellular senescence	28/667	177/7206	0.00524921034868
ko04925	Aldosterone synthesis and secretion	2/667	105/7206	0.00563518488041
ko04976	Bile secretion	1/667	80/7206	0.00607346426009
ko04138	Autophagy - yeast	1/667	81/7206	0.00609433312042
ko04668	TNF signaling pathway	3/667	120/7206	0.00621001007441
ko04750	Inflammatory mediator regulation of TRP channels	3/667	122/7206	0.00645409744847
ko05160	Hepatitis C	5/667	153/7206	0.00678290491788
ko00670	One carbon pool by folate	6/667	20/7206	0.0076871291422
ko05132	Salmonella infection	2/667	98/7206	0.00770479386783
ko00564	Glycerophospholipid metabolism	2/667	99/7206	0.00779132718912
ko04620	Toll-like receptor signaling pathway	2/667	100/7206	0.00794238289253
ko04013	MAPK signaling pathway - fly	3/667	115/7206	0.00867426158982
ko04923	Regulation of lipolysis in adipocytes	1/667	77/7206	0.00896160975887
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1/667	79/7206	0.00936381159691
ko04512	ECM-receptor interaction	1/667	79/7206	0.00936381159691
ko05217	Basal cell carcinoma	13/667	68/7206	0.00990091644553
ko04658	Th1 and Th2 cell differentiation	2/667	96/7206	0.0114533771548
ko04722	Neurotrophin signaling pathway	6/667	160/7206	0.012253195174
ko04540	Gap junction	4/667	128/7206	0.0127231168651
ko05030	Cocaine addiction	1/667	73/7206	0.0131736751205
ko05140	Leishmaniasis	1/667	75/7206	0.0138423768402
ko04146	Peroxisome	2/667	89/7206	0.0156565534193
ko05120	Epithelial cell signaling in Helicobacter pylori infection	2/667	92/7206	0.0164864234528
ko04912	GnRH signaling pathway	4/667	122/7206	0.0172363329896
ko00970	Aminoacyl-tRNA biosynthesis	9/667	44/7206	0.0175220744959
ko04660	T cell receptor signaling pathway	4/667	124/7206	0.0176164810314
ko03320	PPAR signaling pathway	1/667	69/7206	0.0193552010354
ko04068	FoxO signaling pathway	7/667	167/7206	0.0206627400849
ko04142	Lysosome	6/667	151/7206	0.022034564356
ko04213	Longevity regulating pathway - multiple species	2/667	86/7206	0.0226047018466
ko04917	Prolactin signaling pathway	2/667	87/7206	0.0230591268692
ko00561	Glycerolipid metabolism	1/667	63/7206	0.0277023463596
ko00600	Sphingolipid metabolism	1/667	63/7206	0.0277023463596
ko05221	Acute myeloid leukemia	1/667	63/7206	0.0277023463596
ko04622	RIG-I-like receptor signaling pathway	1/667	62/7206	0.0277206734412
ko01200	Carbon metabolism	5/667	128/7206	0.0307730242911
ko05230	Central carbon metabolism in cancer	2/667	81/7206	0.031745739143
ko05211	Renal cell carcinoma	3/667	96/7206	0.0324999409068
ko04962	Vasopressin-regulated water reabsorption	1/667	58/7206	0.0402528375505
ko04115	p53 signaling pathway	12/667	74/7206	0.0442177955231
ko04370	VEGF signaling pathway	2/667	77/7206	0.0450699646163
ko04664	Fc epsilon RI signaling pathway	2/667	77/7206	0.0450699646163