ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 28/293 167/7206 1.01580550197e-10 ko04060 Cytokine-cytokine receptor interaction 30/293 191/7206 1.12988736166e-10 ko04217 Necroptosis 28/293 178/7206 4.73307756102e-10 ko05340 Primary immunodeficiency 12/293 30/7206 7.32982106877e-10 ko04650 Natural killer cell mediated cytotoxicity 20/293 97/7206 1.28147898604e-09 ko05162 Measles 20/293 120/7206 5.92523854288e-08 ko04621 NOD-like receptor signaling pathway 23/293 157/7206 7.16276865136e-08 ko04380 Osteoclast differentiation 21/293 134/7206 8.28611207781e-08 ko04660 T cell receptor signaling pathway 20/293 124/7206 1.04272962957e-07 ko05152 Tuberculosis 25/293 187/7206 1.20280955053e-07 ko04612 Antigen processing and presentation 15/293 77/7206 3.46839777542e-07 ko05145 Toxoplasmosis 19/293 126/7206 6.4639136822e-07 ko05168 Herpes simplex infection 23/293 182/7206 1.08486688531e-06 ko04630 Jak-STAT signaling pathway 19/293 132/7206 1.34193907779e-06 ko05321 Inflammatory bowel disease (IBD) 12/293 56/7206 1.82747877182e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/293 191/7206 2.53477838184e-06 ko04658 Th1 and Th2 cell differentiation 15/293 96/7206 6.39150255057e-06 ko05140 Leishmaniasis 13/293 75/7206 8.32457342066e-06 ko04620 Toll-like receptor signaling pathway 15/293 100/7206 1.06850172986e-05 ko05133 Pertussis 13/293 87/7206 4.33866263159e-05 ko04664 Fc epsilon RI signaling pathway 12/293 77/7206 5.59276232017e-05 ko04659 Th17 cell differentiation 14/293 106/7206 8.95256575903e-05 ko04145 Phagosome 18/293 162/7206 9.38755040533e-05 ko00120 Primary bile acid biosynthesis 6/293 20/7206 0.00010267770695 ko04064 NF-kappa B signaling pathway 13/293 96/7206 0.000123213604257 ko04062 Chemokine signaling pathway 20/293 201/7206 0.000180617908202 ko04662 B cell receptor signaling pathway 12/293 88/7206 0.000209527185053 ko00590 Arachidonic acid metabolism 9/293 52/7206 0.000211507118629 ko05330 Allograft rejection 6/293 24/7206 0.000310711753239 ko04611 Platelet activation 17/293 163/7206 0.000316188008544 ko04666 Fc gamma R-mediated phagocytosis 14/293 122/7206 0.000403468288914 ko05150 Staphylococcus aureus infection 7/293 36/7206 0.000516615063965 ko05132 Salmonella infection 12/293 98/7206 0.000576615857514 ko04672 Intestinal immune network for IgA production 7/293 37/7206 0.000615335090319 ko05161 Hepatitis B 17/293 173/7206 0.000634390816906 ko05142 Chagas disease (American trypanosomiasis) 14/293 130/7206 0.000770324223288 ko05320 Autoimmune thyroid disease 6/293 29/7206 0.000923793632953 ko00980 Metabolism of xenobiotics by cytochrome P450 7/293 40/7206 0.00100378494125 ko04080 Neuroactive ligand-receptor interaction 6/293 423/7206 0.00215478679295 ko05204 Chemical carcinogenesis 7/293 48/7206 0.00300349658101 ko04210 Apoptosis 16/293 180/7206 0.00312340172811 ko04668 TNF signaling pathway 12/293 120/7206 0.00337939453651 ko04622 RIG-I-like receptor signaling pathway 8/293 62/7206 0.00339449905888 ko00982 Drug metabolism - cytochrome P450 6/293 37/7206 0.00344113343035 ko01524 Platinum drug resistance 9/293 76/7206 0.00349134514496 ko04640 Hematopoietic cell lineage 8/293 64/7206 0.00414332731657 ko05310 Asthma 4/293 17/7206 0.00418749073435 ko05332 Graft-versus-host disease 4/293 18/7206 0.00521407231757 ko05160 Hepatitis C 14/293 153/7206 0.00527957233796 ko00140 Steroid hormone biosynthesis 6/293 41/7206 0.00581029801122 ko00480 Glutathione metabolism 7/293 55/7206 0.0065007575616 ko05034 Alcoholism 2/293 238/7206 0.0065057014299 ko04310 Wnt signaling pathway 1/293 181/7206 0.00715132979986 ko04390 Hippo signaling pathway 1/293 188/7206 0.00739760391929 ko05144 Malaria 6/293 45/7206 0.009192736413 ko04670 Leukocyte transendothelial migration 13/293 151/7206 0.0100838659313 ko04610 Complement and coagulation cascades 8/293 79/7206 0.0144844054404 ko05131 Shigellosis 8/293 82/7206 0.0178349657403 ko02010 ABC transporters 5/293 39/7206 0.0199184779632 ko03050 Proteasome 6/293 54/7206 0.0215341745051 ko05012 Parkinson's disease 1/293 155/7206 0.0217965417176 ko05416 Viral myocarditis 6/293 55/7206 0.0233750010696 ko04530 Tight junction 3/293 228/7206 0.0261011519709 ko05323 Rheumatoid arthritis 8/293 89/7206 0.0277530797772 ko04916 Melanogenesis 1/293 142/7206 0.0311949148961 ko04940 Type I diabetes mellitus 4/293 32/7206 0.0393167540132 ko00592 alpha-Linolenic acid metabolism 3/293 19/7206 0.0397937594198 ko00966 Glucosinolate biosynthesis 1/293 1/7206 0.0406605606441 ko04215 Apoptosis - multiple species 5/293 47/7206 0.0408876957709 ko04514 Cell adhesion molecules (CAMs) 10/293 130/7206 0.0428539616192 ko04137 Mitophagy - animal 7/293 82/7206 0.0485045541072 ko00750 Vitamin B6 metabolism 2/293 9/7206 0.0491010050131 ko04723 Retrograde endocannabinoid signaling 2/293 175/7206 0.0495689666305