ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1267	423/7206	2.61413661451e-50
ko04724	Glutamatergic synapse	90/1267	152/7206	3.26085356407e-31
ko05033	Nicotine addiction	47/1267	56/7206	2.36992497499e-27
ko04713	Circadian entrainment	78/1267	136/7206	6.87986551357e-26
ko05032	Morphine addiction	68/1267	110/7206	2.28653823893e-25
ko04727	GABAergic synapse	65/1267	110/7206	9.72226515071e-23
ko04728	Dopaminergic synapse	86/1267	185/7206	3.40762038588e-20
ko04725	Cholinergic synapse	77/1267	160/7206	2.62956219662e-19
ko04020	Calcium signaling pathway	105/1267	265/7206	5.68260266562e-18
ko04723	Retrograde endocannabinoid signaling	79/1267	175/7206	1.08119863892e-17
ko04911	Insulin secretion	60/1267	117/7206	5.73057646883e-17
ko04721	Synaptic vesicle cycle	47/1267	80/7206	1.24195795843e-16
ko04024	cAMP signaling pathway	106/1267	279/7206	1.2868723837e-16
ko04726	Serotonergic synapse	63/1267	137/7206	8.15332482646e-15
ko04921	Oxytocin signaling pathway	82/1267	209/7206	7.61604842306e-14
ko04742	Taste transduction	36/1267	61/7206	4.01305034254e-13
ko05031	Amphetamine addiction	44/1267	91/7206	1.18984174149e-11
ko04970	Salivary secretion	45/1267	95/7206	1.69607723503e-11
ko04744	Phototransduction	24/1267	36/7206	9.01877916132e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1267	205/7206	3.24820144594e-10
ko03040	Spliceosome	2/1267	145/7206	3.72353392221e-10
ko04720	Long-term potentiation	44/1267	99/7206	3.87664286736e-10
ko03010	Ribosome	1/1267	129/7206	5.60977320989e-10
ko04925	Aldosterone synthesis and secretion	44/1267	105/7206	5.04488051822e-09
ko04022	cGMP-PKG signaling pathway	71/1267	216/7206	3.0854449979e-08
ko04971	Gastric acid secretion	40/1267	98/7206	5.17899648339e-08
ko05322	Systemic lupus erythematosus	5/1267	151/7206	1.05500015136e-07
ko05168	Herpes simplex infection	9/1267	182/7206	5.08204926673e-07
ko05030	Cocaine addiction	31/1267	73/7206	5.36587220715e-07
ko04972	Pancreatic secretion	41/1267	111/7206	9.24205549325e-07
ko03013	RNA transport	8/1267	166/7206	1.32899604885e-06
ko04730	Long-term depression	31/1267	78/7206	3.2379836082e-06
ko04070	Phosphatidylinositol signaling system	40/1267	112/7206	3.78834357171e-06
ko04360	Axon guidance	69/1267	233/7206	4.3047666544e-06
ko04072	Phospholipase D signaling pathway	59/1267	197/7206	1.56469589192e-05
ko04745	Phototransduction - fly	18/1267	38/7206	2.18599992632e-05
ko04010	MAPK signaling pathway	86/1267	321/7206	2.41695632971e-05
ko04966	Collecting duct acid secretion	14/1267	26/7206	2.95013771467e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1267	74/7206	3.59671085243e-05
ko04014	Ras signaling pathway	76/1267	279/7206	3.92314256696e-05
ko04060	Cytokine-cytokine receptor interaction	14/1267	191/7206	4.6088411367e-05
ko04621	NOD-like receptor signaling pathway	10/1267	157/7206	4.77872634683e-05
ko05203	Viral carcinogenesis	25/1267	277/7206	5.22574820392e-05
ko04540	Gap junction	41/1267	128/7206	5.51483379752e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1267	79/7206	7.12523853441e-05
ko04110	Cell cycle	9/1267	145/7206	9.23964396889e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1267	122/7206	9.69115326977e-05
ko04141	Protein processing in endoplasmic reticulum	14/1267	184/7206	0.000115595705436
ko05164	Influenza A	12/1267	167/7206	0.000124136150253
ko04740	Olfactory transduction	28/1267	80/7206	0.000160975866096
ko04371	Apelin signaling pathway	51/1267	177/7206	0.00018876998046
ko04514	Cell adhesion molecules (CAMs)	40/1267	130/7206	0.000255709265613
ko05110	Vibrio cholerae infection	23/1267	63/7206	0.000324632545803
ko04270	Vascular smooth muscle contraction	45/1267	154/7206	0.000355604049425
ko04612	Antigen processing and presentation	3/1267	77/7206	0.000445845980511
ko04976	Bile secretion	27/1267	80/7206	0.000514941960394
ko04964	Proximal tubule bicarbonate reclamation	13/1267	29/7206	0.00060019090581
ko04922	Glucagon signaling pathway	38/1267	128/7206	0.000619802070084
ko05162	Measles	8/1267	120/7206	0.000652525984497
ko05169	Epstein-Barr virus infection	19/1267	206/7206	0.00078731563099
ko04710	Circadian rhythm	17/1267	43/7206	0.000791531024831
ko04924	Renin secretion	28/1267	86/7206	0.000836276527666
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1267	79/7206	0.000880811279162
ko04915	Estrogen signaling pathway	38/1267	131/7206	0.0010771548773
ko04120	Ubiquitin mediated proteolysis	11/1267	138/7206	0.00150167926474
ko05414	Dilated cardiomyopathy	33/1267	112/7206	0.00164366214755
ko04064	NF-kappa B signaling pathway	6/1267	96/7206	0.00173226278759
ko05144	Malaria	1/1267	45/7206	0.00274215545943
ko03420	Nucleotide excision repair	1/1267	46/7206	0.00280301913637
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1267	59/7206	0.0028091291902
ko04260	Cardiac muscle contraction	29/1267	98/7206	0.00303464853215
ko05140	Leishmaniasis	4/1267	75/7206	0.00326691061442
ko04217	Necroptosis	17/1267	178/7206	0.00361993256358
ko00280	Valine, leucine and isoleucine degradation	2/1267	54/7206	0.00363773855323
ko00520	Amino sugar and nucleotide sugar metabolism	2/1267	55/7206	0.0037122700662
ko03022	Basal transcription factors	1/1267	44/7206	0.00431298745353
ko04912	GnRH signaling pathway	34/1267	122/7206	0.00536586711644
ko04930	Type II diabetes mellitus	18/1267	54/7206	0.00594034758114
ko05161	Hepatitis B	17/1267	173/7206	0.00603732289645
ko04622	RIG-I-like receptor signaling pathway	3/1267	62/7206	0.00636325807609
ko04657	IL-17 signaling pathway	6/1267	87/7206	0.00652180273005
ko05133	Pertussis	6/1267	87/7206	0.00652180273005
ko04610	Complement and coagulation cascades	5/1267	79/7206	0.00672724832209
ko04626	Plant-pathogen interaction	8/1267	18/7206	0.00738615949253
ko03410	Base excision repair	1/1267	38/7206	0.00942025582204
ko04918	Thyroid hormone synthesis	25/1267	86/7206	0.00944399563138
ko04923	Regulation of lipolysis in adipocytes	23/1267	77/7206	0.00953279254683
ko04916	Melanogenesis	37/1267	142/7206	0.0101578701243
ko05016	Huntington's disease	24/1267	215/7206	0.0106857859555
ko04960	Aldosterone-regulated sodium reabsorption	14/1267	41/7206	0.0113696829909
ko05131	Shigellosis	6/1267	82/7206	0.0123076070816
ko04142	Lysosome	15/1267	151/7206	0.0124470429144
ko04214	Apoptosis - fly	5/1267	72/7206	0.0126888644283
ko04973	Carbohydrate digestion and absorption	14/1267	42/7206	0.0129054620219
ko04658	Th1 and Th2 cell differentiation	8/1267	96/7206	0.0145277762273
ko04630	Jak-STAT signaling pathway	13/1267	132/7206	0.015359667276
ko05145	Toxoplasmosis	12/1267	126/7206	0.0174599349276
ko05205	Proteoglycans in cancer	33/1267	271/7206	0.0180052693608
ko04015	Rap1 signaling pathway	64/1267	278/7206	0.0194823844187
ko05231	Choline metabolism in cancer	34/1267	134/7206	0.0215000064876
ko00860	Porphyrin and chlorophyll metabolism	1/1267	34/7206	0.021549466382
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1267	14/7206	0.0243686411468
ko00562	Inositol phosphate metabolism	24/1267	89/7206	0.0244913180855
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1267	182/7206	0.0297232080207
ko04666	Fc gamma R-mediated phagocytosis	31/1267	122/7206	0.0299360293842
ko04115	p53 signaling pathway	6/1267	74/7206	0.0307388864789
ko00240	Pyrimidine metabolism	11/1267	110/7206	0.0321126866433
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1267	100/7206	0.033407499501
ko05321	Inflammatory bowel disease (IBD)	4/1267	56/7206	0.0349346374917
ko05219	Bladder cancer	3/1267	48/7206	0.0358921558788
ko04210	Apoptosis	21/1267	180/7206	0.0367876185013
ko04620	Toll-like receptor signaling pathway	10/1267	100/7206	0.0466125797404
ko05416	Viral myocarditis	4/1267	55/7206	0.048613595937
ko05130	Pathogenic Escherichia coli infection	7/1267	77/7206	0.0499821430454