ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 32/547 134/7206 3.08207265474e-09 ko00120 Primary bile acid biosynthesis 11/547 20/7206 3.90648470083e-08 ko04060 Cytokine-cytokine receptor interaction 36/547 191/7206 2.34373450881e-07 ko04064 NF-kappa B signaling pathway 20/547 96/7206 2.60855685555e-05 ko04621 NOD-like receptor signaling pathway 27/547 157/7206 4.69204582005e-05 ko05321 Inflammatory bowel disease (IBD) 14/547 56/7206 5.24686266524e-05 ko04710 Circadian rhythm 12/547 43/7206 5.60191883744e-05 ko04137 Mitophagy - animal 17/547 82/7206 0.000111215690324 ko03040 Spliceosome 1/547 145/7206 0.000204020053231 ko04610 Complement and coagulation cascades 16/547 79/7206 0.000234257013668 ko04668 TNF signaling pathway 21/547 120/7206 0.000306579927427 ko04650 Natural killer cell mediated cytotoxicity 18/547 97/7206 0.000308859479324 ko03013 RNA transport 2/547 166/7206 0.00031112871398 ko04672 Intestinal immune network for IgA production 10/547 37/7206 0.000311817370371 ko04660 T cell receptor signaling pathway 21/547 124/7206 0.000426822186975 ko05164 Influenza A 26/547 167/7206 0.000500582371551 ko00350 Tyrosine metabolism 9/547 33/7206 0.000578251279 ko03010 Ribosome 1/547 129/7206 0.000652866049192 ko00051 Fructose and mannose metabolism 10/547 42/7206 0.000932756564207 ko05152 Tuberculosis 27/547 187/7206 0.00108076922734 ko05150 Staphylococcus aureus infection 9/547 36/7206 0.00114978715648 ko04659 Th17 cell differentiation 18/547 106/7206 0.0011523774582 ko04630 Jak-STAT signaling pathway 21/547 132/7206 0.00120809672699 ko05140 Leishmaniasis 14/547 75/7206 0.00132572205407 ko00590 Arachidonic acid metabolism 11/547 52/7206 0.00150047003515 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/547 4/7206 0.00164214144396 ko00643 Styrene degradation 3/547 4/7206 0.00164214144396 ko05145 Toxoplasmosis 20/547 126/7206 0.00170043901456 ko03320 PPAR signaling pathway 13/547 69/7206 0.0017871092685 ko00592 alpha-Linolenic acid metabolism 6/547 19/7206 0.00214569871253 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/547 191/7206 0.00325158663298 ko05323 Rheumatoid arthritis 15/547 89/7206 0.00347111141597 ko04723 Retrograde endocannabinoid signaling 4/547 175/7206 0.00361989522368 ko04068 FoxO signaling pathway 23/547 167/7206 0.00456291076102 ko00950 Isoquinoline alkaloid biosynthesis 4/547 10/7206 0.00476387221107 ko05224 Breast cancer 4/547 174/7206 0.00521750455894 ko00330 Arginine and proline metabolism 11/547 61/7206 0.0055808328619 ko05144 Malaria 9/547 45/7206 0.00586959164912 ko04658 Th1 and Th2 cell differentiation 15/547 96/7206 0.00598144749802 ko05340 Primary immunodeficiency 7/547 30/7206 0.00610473202677 ko04110 Cell cycle 3/547 145/7206 0.00652805598234 ko04662 B cell receptor signaling pathway 14/547 88/7206 0.00703742728196 ko00360 Phenylalanine metabolism 5/547 17/7206 0.00710700561386 ko04390 Hippo signaling pathway 5/547 188/7206 0.00728135493538 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/547 135/7206 0.00783963583533 ko05034 Alcoholism 8/547 238/7206 0.0086586588586 ko00140 Steroid hormone biosynthesis 8/547 41/7206 0.0106969324765 ko04620 Toll-like receptor signaling pathway 15/547 100/7206 0.0113316250856 ko05162 Measles 17/547 120/7206 0.0131174127831 ko04217 Necroptosis 23/547 178/7206 0.0136665448758 ko04111 Cell cycle - yeast 1/547 90/7206 0.0141356609976 ko04391 Hippo signaling pathway - fly 1/547 90/7206 0.0141356609976 ko04611 Platelet activation 21/547 163/7206 0.0156318083943 ko05160 Hepatitis C 20/547 153/7206 0.0189858010848 ko04072 Phospholipase D signaling pathway 24/547 197/7206 0.0195306742406 ko00564 Glycerophospholipid metabolism 14/547 99/7206 0.0203399437842 ko04550 Signaling pathways regulating pluripotency of stem cells 5/547 165/7206 0.024253907456 ko00220 Arginine biosynthesis 5/547 24/7206 0.0314567000847 ko05168 Herpes simplex infection 22/547 182/7206 0.0317457423403 ko04932 Non-alcoholic fatty liver disease (NAFLD) 22/547 182/7206 0.0317457423403 ko04623 Cytosolic DNA-sensing pathway 7/547 41/7206 0.0327927963659 ko00830 Retinol metabolism 7/547 42/7206 0.036878912158 ko00565 Ether lipid metabolism 7/547 42/7206 0.036878912158 ko05133 Pertussis 12/547 87/7206 0.0388396175111 ko04062 Chemokine signaling pathway 23/547 201/7206 0.0423394962161 ko05322 Systemic lupus erythematosus 5/547 151/7206 0.0427172562612 ko04146 Peroxisome 12/547 89/7206 0.0429050228955 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/547 5/7206 0.0493037314613