ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 30/325 134/7206 1.18360486493e-13 ko04060 Cytokine-cytokine receptor interaction 34/325 191/7206 2.90859459215e-12 ko04621 NOD-like receptor signaling pathway 28/325 157/7206 2.58662696419e-10 ko04668 TNF signaling pathway 24/325 120/7206 4.55477921825e-10 ko05164 Influenza A 27/325 167/7206 5.20479774731e-09 ko04064 NF-kappa B signaling pathway 19/325 96/7206 3.75657547167e-08 ko04657 IL-17 signaling pathway 17/325 87/7206 2.41991914657e-07 ko05133 Pertussis 17/325 87/7206 2.41991914657e-07 ko05160 Hepatitis C 22/325 153/7206 1.16193013009e-06 ko04623 Cytosolic DNA-sensing pathway 11/325 41/7206 1.24224183279e-06 ko05168 Herpes simplex infection 24/325 182/7206 1.86004954088e-06 ko04620 Toll-like receptor signaling pathway 17/325 100/7206 1.90341643722e-06 ko04660 T cell receptor signaling pathway 19/325 124/7206 2.40981209186e-06 ko04622 RIG-I-like receptor signaling pathway 13/325 62/7206 2.82155184808e-06 ko05145 Toxoplasmosis 19/325 126/7206 3.08117004971e-06 ko05140 Leishmaniasis 14/325 75/7206 5.02068997424e-06 ko04672 Intestinal immune network for IgA production 9/325 37/7206 2.80556327915e-05 ko04666 Fc gamma R-mediated phagocytosis 17/325 122/7206 2.96999077674e-05 ko05161 Hepatitis B 21/325 173/7206 3.00930286365e-05 ko05131 Shigellosis 13/325 82/7206 6.69867703681e-05 ko04650 Natural killer cell mediated cytotoxicity 14/325 97/7206 0.00010183628485 ko04662 B cell receptor signaling pathway 13/325 88/7206 0.000141216648063 ko05323 Rheumatoid arthritis 13/325 89/7206 0.000158779902775 ko04210 Apoptosis 20/325 180/7206 0.000162011511456 ko04512 ECM-receptor interaction 12/325 79/7206 0.000194018807881 ko05340 Primary immunodeficiency 7/325 30/7206 0.000294962131955 ko05162 Measles 15/325 120/7206 0.00030002232338 ko04658 Th1 and Th2 cell differentiation 13/325 96/7206 0.00034294925303 ko05132 Salmonella infection 13/325 98/7206 0.000420978582826 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/325 191/7206 0.000491557513649 ko04640 Hematopoietic cell lineage 10/325 64/7206 0.000523086586498 ko04217 Necroptosis 19/325 178/7206 0.000638795303751 ko05142 Chagas disease (American trypanosomiasis) 15/325 130/7206 0.000712775398724 ko04610 Complement and coagulation cascades 11/325 79/7206 0.00076551950192 ko05321 Inflammatory bowel disease (IBD) 9/325 56/7206 0.000802195010819 ko05152 Tuberculosis 19/325 187/7206 0.000891101311817 ko05150 Staphylococcus aureus infection 7/325 36/7206 0.000958133527625 ko04933 AGE-RAGE signaling pathway in diabetic complications 15/325 135/7206 0.00105749083378 ko05418 Fluid shear stress and atherosclerosis 18/325 173/7206 0.00106846493045 ko04670 Leukocyte transendothelial migration 16/325 151/7206 0.00121551432243 ko05134 Legionellosis 10/325 74/7206 0.00166462178549 ko05034 Alcoholism 2/325 238/7206 0.00215941079271 ko04810 Regulation of actin cytoskeleton 23/325 264/7206 0.00217217664405 ko00051 Fructose and mannose metabolism 7/325 42/7206 0.00245539421045 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/325 92/7206 0.00270402366559 ko04659 Th17 cell differentiation 12/325 106/7206 0.00280441699848 ko05416 Viral myocarditis 8/325 55/7206 0.00299471239175 ko05144 Malaria 7/325 45/7206 0.00367919934218 ko05330 Allograft rejection 5/325 24/7206 0.0037855519248 ko04723 Retrograde endocannabinoid signaling 1/325 175/7206 0.00490567749808 ko04062 Chemokine signaling pathway 18/325 201/7206 0.00497654306889 ko05410 Hypertrophic cardiomyopathy (HCM) 11/325 100/7206 0.00517633781317 ko04510 Focal adhesion 20/325 240/7206 0.00677658319603 ko04664 Fc epsilon RI signaling pathway 9/325 77/7206 0.00746396296008 ko05332 Graft-versus-host disease 4/325 18/7206 0.0075196162978 ko04611 Platelet activation 15/325 163/7206 0.0110061876069 ko00643 Styrene degradation 2/325 4/7206 0.0114536204443 ko00350 Tyrosine metabolism 5/325 33/7206 0.0151817980023 ko04917 Prolactin signaling pathway 9/325 87/7206 0.0160517069069 ko04514 Cell adhesion molecules (CAMs) 12/325 130/7206 0.0163959948856 ko04630 Jak-STAT signaling pathway 12/325 132/7206 0.0178458812478 ko04728 Dopaminergic synapse 2/325 185/7206 0.0178995354405 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/325 5/7206 0.0185230633138 ko05016 Huntington's disease 3/325 215/7206 0.0188426269847 ko05166 HTLV-I infection 22/325 292/7206 0.0197618848384 ko04114 Oocyte meiosis 1/325 139/7206 0.0215644789202 ko04612 Antigen processing and presentation 8/325 77/7206 0.022064168443 ko04713 Circadian entrainment 1/325 136/7206 0.0328319129006 ko04931 Insulin resistance 12/325 137/7206 0.0333383684046 ko04550 Signaling pathways regulating pluripotency of stem cells 2/325 165/7206 0.034953553817 ko00360 Phenylalanine metabolism 3/325 17/7206 0.0386377357425 ko05310 Asthma 3/325 17/7206 0.0386377357425 ko05320 Autoimmune thyroid disease 4/325 29/7206 0.0396187508596 ko05100 Bacterial invasion of epithelial cells 9/325 99/7206 0.044034907759 ko05146 Amoebiasis 9/325 99/7206 0.044034907759 ko00401 Novobiocin biosynthesis 1/325 1/7206 0.0451013044684 ko00190 Oxidative phosphorylation 1/325 127/7206 0.0470789549949 ko05012 Parkinson's disease 2/325 155/7206 0.0486942758444 ko04390 Hippo signaling pathway 3/325 188/7206 0.0489479300183