ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 29/486 68/7206 5.68597535663e-17 ko04390 Hippo signaling pathway 41/486 188/7206 8.51069748141e-12 ko04550 Signaling pathways regulating pluripotency of stem cells 37/486 165/7206 3.91710509302e-11 ko04310 Wnt signaling pathway 36/486 181/7206 2.48960813915e-09 ko04080 Neuroactive ligand-receptor interaction 4/486 423/7206 5.51194359617e-09 ko05224 Breast cancer 34/486 174/7206 1.12845077277e-08 ko04340 Hedgehog signaling pathway 18/486 58/7206 2.19017643455e-08 ko04330 Notch signaling pathway 18/486 62/7206 6.98263494122e-08 ko04110 Cell cycle 27/486 145/7206 1.03218298019e-06 ko04360 Axon guidance 36/486 233/7206 3.13838431594e-06 ko03040 Spliceosome 26/486 145/7206 3.42574223638e-06 ko04391 Hippo signaling pathway - fly 19/486 90/7206 6.34125100056e-06 ko03050 Proteasome 14/486 54/7206 8.83199392663e-06 ko03015 mRNA surveillance pathway 19/486 93/7206 1.04969560408e-05 ko05205 Proteoglycans in cancer 38/486 271/7206 1.74915179627e-05 ko05200 Pathways in cancer 58/486 492/7206 2.23361741863e-05 ko04350 TGF-beta signaling pathway 19/486 103/7206 4.76303125098e-05 ko05169 Epstein-Barr virus infection 30/486 206/7206 5.26805957113e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/486 182/7206 6.6783236158e-05 ko04950 Maturity onset diabetes of the young 9/486 29/7206 7.93670187433e-05 ko04921 Oxytocin signaling pathway 2/486 209/7206 0.000110088365104 ko05010 Alzheimer's disease 2/486 202/7206 0.000157026315007 ko04111 Cell cycle - yeast 16/486 90/7206 0.000291062307226 ko04725 Cholinergic synapse 1/486 160/7206 0.000322386195085 ko04020 Calcium signaling pathway 5/486 265/7206 0.000400594819771 ko03410 Base excision repair 9/486 38/7206 0.000748792517226 ko03030 DNA replication 9/486 38/7206 0.000748792517226 ko04144 Endocytosis 9/486 342/7206 0.000834443700433 ko05202 Transcriptional misregulation in cancer 25/486 188/7206 0.000974047749081 ko04022 cGMP-PKG signaling pathway 4/486 216/7206 0.00137665395935 ko04726 Serotonergic synapse 1/486 137/7206 0.00151356749248 ko04922 Glucagon signaling pathway 1/486 128/7206 0.00214114595732 ko04915 Estrogen signaling pathway 1/486 131/7206 0.00221089206828 ko04630 Jak-STAT signaling pathway 1/486 132/7206 0.00225956504223 ko04723 Retrograde endocannabinoid signaling 3/486 175/7206 0.00340060897373 ko04072 Phospholipase D signaling pathway 4/486 197/7206 0.00371927062788 ko04013 MAPK signaling pathway - fly 16/486 115/7206 0.00456866687278 ko04910 Insulin signaling pathway 3/486 172/7206 0.0049012256226 ko04612 Antigen processing and presentation 12/486 77/7206 0.00507656005059 ko05206 MicroRNAs in cancer 22/486 177/7206 0.00548228437313 ko05166 HTLV-I infection 32/486 292/7206 0.00580378586899 ko05222 Small cell lung cancer 13/486 89/7206 0.00826156191875 ko05231 Choline metabolism in cancer 2/486 134/7206 0.00837511808491 ko04931 Insulin resistance 2/486 137/7206 0.00862802840975 ko04925 Aldosterone synthesis and secretion 1/486 105/7206 0.00972559496912 ko04916 Melanogenesis 18/486 142/7206 0.0097793860805 ko04217 Necroptosis 4/486 178/7206 0.00979498485049 ko04062 Chemokine signaling pathway 5/486 201/7206 0.00986010220753 ko04341 Hedgehog signaling pathway - fly 7/486 38/7206 0.012321261457 ko05034 Alcoholism 7/486 238/7206 0.0123825020917 ko00514 Other types of O-glycan biosynthesis 6/486 30/7206 0.0135067758617 ko04971 Gastric acid secretion 1/486 98/7206 0.0140793904375 ko04211 Longevity regulating pathway 2/486 123/7206 0.0169440823008 ko04066 HIF-1 signaling pathway 2/486 123/7206 0.0169440823008 ko05211 Renal cell carcinoma 1/486 96/7206 0.0212751610099 ko04911 Insulin secretion 2/486 117/7206 0.0239313386569 ko04011 MAPK signaling pathway - yeast 8/486 53/7206 0.0244340928252 ko04113 Meiosis - yeast 10/486 70/7206 0.0255401675288 ko04924 Renin secretion 1/486 86/7206 0.0295515589623 ko04662 B cell receptor signaling pathway 1/486 88/7206 0.0298823828217 ko04920 Adipocytokine signaling pathway 1/486 89/7206 0.0302500476457 ko05031 Amphetamine addiction 1/486 91/7206 0.0313903376721 ko04270 Vascular smooth muscle contraction 4/486 154/7206 0.0339354781092 ko04070 Phosphatidylinositol signaling system 2/486 112/7206 0.0340370291248 ko04621 NOD-like receptor signaling pathway 4/486 157/7206 0.0344952071146 ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 4/486 19/7206 0.0352196404532 ko04713 Circadian entrainment 3/486 136/7206 0.0356524678669 ko05130 Pathogenic Escherichia coli infection 10/486 77/7206 0.0376229725496 ko00670 One carbon pool by folate 4/486 20/7206 0.0417542194379 ko04512 ECM-receptor interaction 10/486 79/7206 0.0425431739192 ko04721 Synaptic vesicle cycle 1/486 80/7206 0.0426806431517 ko04976 Bile secretion 1/486 80/7206 0.0426806431517 ko04740 Olfactory transduction 1/486 80/7206 0.0426806431517 ko05230 Central carbon metabolism in cancer 1/486 81/7206 0.042825902765 ko04138 Autophagy - yeast 1/486 81/7206 0.042825902765 ko05322 Systemic lupus erythematosus 4/486 151/7206 0.0466829391472 ko04212 Longevity regulating pathway - worm 11/486 87/7206 0.0475509447078 ko04151 PI3K-Akt signaling pathway 36/486 390/7206 0.0484194687487