ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1258	423/7206	1.49837361327e-51
ko04724	Glutamatergic synapse	88/1258	152/7206	9.33930137188e-30
ko05033	Nicotine addiction	47/1258	56/7206	1.70716544471e-27
ko04713	Circadian entrainment	78/1258	136/7206	4.22728825331e-26
ko05032	Morphine addiction	68/1258	110/7206	1.47920637214e-25
ko04727	GABAergic synapse	64/1258	110/7206	4.54185101236e-22
ko04721	Synaptic vesicle cycle	51/1258	80/7206	2.56925001511e-20
ko04728	Dopaminergic synapse	85/1258	185/7206	9.04623775365e-20
ko04725	Cholinergic synapse	76/1258	160/7206	7.74166507048e-19
ko04020	Calcium signaling pathway	106/1258	265/7206	9.20740886927e-19
ko04723	Retrograde endocannabinoid signaling	77/1258	175/7206	1.12895585345e-16
ko04024	cAMP signaling pathway	105/1258	279/7206	3.58243448219e-16
ko04742	Taste transduction	38/1258	61/7206	5.70378378594e-15
ko04726	Serotonergic synapse	63/1258	137/7206	5.7426814808e-15
ko04911	Insulin secretion	56/1258	117/7206	2.25601275664e-14
ko04921	Oxytocin signaling pathway	82/1258	209/7206	3.59453830611e-14
ko04970	Salivary secretion	46/1258	95/7206	2.90948650326e-12
ko04744	Phototransduction	24/1258	36/7206	7.72049205359e-11
ko04720	Long-term potentiation	44/1258	99/7206	3.05441096513e-10
ko03040	Spliceosome	2/1258	145/7206	5.94231399338e-10
ko05031	Amphetamine addiction	41/1258	91/7206	7.43378351417e-10
ko04261	Adrenergic signaling in cardiomyocytes	72/1258	205/7206	8.90309818713e-10
ko04360	Axon guidance	77/1258	233/7206	4.0020351722e-09
ko05203	Viral carcinogenesis	17/1258	277/7206	2.61949022192e-08
ko04022	cGMP-PKG signaling pathway	70/1258	216/7206	7.67241182633e-08
ko03013	RNA transport	7/1258	166/7206	2.5487538788e-07
ko04925	Aldosterone synthesis and secretion	40/1258	105/7206	3.86114995714e-07
ko05322	Systemic lupus erythematosus	6/1258	151/7206	6.43449666218e-07
ko04924	Renin secretion	34/1258	86/7206	1.03224929725e-06
ko04971	Gastric acid secretion	37/1258	98/7206	1.37247919853e-06
ko05168	Herpes simplex infection	10/1258	182/7206	2.31564611733e-06
ko04060	Cytokine-cytokine receptor interaction	11/1258	191/7206	2.48474947416e-06
ko04540	Gap junction	44/1258	128/7206	2.98571189442e-06
ko05164	Influenza A	9/1258	167/7206	4.2204440725e-06
ko04966	Collecting duct acid secretion	15/1258	26/7206	4.42818798271e-06
ko04740	Olfactory transduction	31/1258	80/7206	4.97879377601e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1258	74/7206	8.06036801597e-06
ko04514	Cell adhesion molecules (CAMs)	43/1258	130/7206	1.19377681145e-05
ko04730	Long-term depression	30/1258	78/7206	1.32338073653e-05
ko05030	Cocaine addiction	28/1258	73/7206	1.7905599573e-05
ko04120	Ubiquitin mediated proteolysis	7/1258	138/7206	2.06701479492e-05
ko04010	MAPK signaling pathway	86/1258	321/7206	2.20226749561e-05
ko04070	Phosphatidylinositol signaling system	38/1258	112/7206	2.31954955764e-05
ko04972	Pancreatic secretion	37/1258	111/7206	4.13680809439e-05
ko04621	NOD-like receptor signaling pathway	10/1258	157/7206	6.79229002665e-05
ko04610	Complement and coagulation cascades	2/1258	79/7206	7.02635233305e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1258	79/7206	7.02635233305e-05
ko04110	Cell cycle	9/1258	145/7206	9.1926335689e-05
ko04976	Bile secretion	28/1258	80/7206	0.000148370564668
ko04141	Protein processing in endoplasmic reticulum	14/1258	184/7206	0.000159908261119
ko05169	Epstein-Barr virus infection	17/1258	206/7206	0.000177241446478
ko04260	Cardiac muscle contraction	32/1258	98/7206	0.000232041758272
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1258	79/7206	0.000278400084288
ko04745	Phototransduction - fly	16/1258	38/7206	0.000317586496457
ko04014	Ras signaling pathway	72/1258	279/7206	0.000371955968732
ko04750	Inflammatory mediator regulation of TRP channels	37/1258	122/7206	0.00041762640268
ko04964	Proximal tubule bicarbonate reclamation	13/1258	29/7206	0.0005588391391
ko04064	NF-kappa B signaling pathway	5/1258	96/7206	0.000596077066784
ko05140	Leishmaniasis	3/1258	75/7206	0.000658693118417
ko05110	Vibrio cholerae infection	22/1258	63/7206	0.000709730015475
ko04710	Circadian rhythm	17/1258	43/7206	0.000762045225826
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1258	59/7206	0.00078223730861
ko04072	Phospholipase D signaling pathway	53/1258	197/7206	0.000798828767088
ko04371	Apelin signaling pathway	48/1258	177/7206	0.00122705095705
ko05161	Hepatitis B	15/1258	173/7206	0.00153463940097
ko05414	Dilated cardiomyopathy	33/1258	112/7206	0.00153898174018
ko04626	Plant-pathogen interaction	9/1258	18/7206	0.00157043074599
ko04146	Peroxisome	5/1258	89/7206	0.001718076511
ko05162	Measles	9/1258	120/7206	0.00226934389288
ko05205	Proteoglycans in cancer	29/1258	271/7206	0.00243040334779
ko05144	Malaria	1/1258	45/7206	0.00276826969665
ko00071	Fatty acid degradation	1/1258	45/7206	0.00276826969665
ko03420	Nucleotide excision repair	1/1258	46/7206	0.00278895492202
ko04923	Regulation of lipolysis in adipocytes	24/1258	77/7206	0.0035501366357
ko04915	Estrogen signaling pathway	36/1258	131/7206	0.00356461054901
ko00480	Glutathione metabolism	2/1258	55/7206	0.00369199393006
ko05321	Inflammatory bowel disease (IBD)	2/1258	56/7206	0.00385045147354
ko03022	Basal transcription factors	1/1258	44/7206	0.00427141125347
ko00310	Lysine degradation	4/1258	73/7206	0.00466202395989
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1258	14/7206	0.00533009436426
ko00590	Arachidonic acid metabolism	2/1258	52/7206	0.00538623862143
ko04930	Type II diabetes mellitus	18/1258	54/7206	0.00580574396447
ko00330	Arginine and proline metabolism	3/1258	61/7206	0.00613176348132
ko04622	RIG-I-like receptor signaling pathway	3/1258	62/7206	0.00627874449521
ko04657	IL-17 signaling pathway	6/1258	87/7206	0.0065017860088
ko05133	Pertussis	6/1258	87/7206	0.0065017860088
ko00240	Pyrimidine metabolism	9/1258	110/7206	0.00752878134779
ko00380	Tryptophan metabolism	2/1258	50/7206	0.00793583256127
ko05145	Toxoplasmosis	11/1258	126/7206	0.00866126389938
ko03018	RNA degradation	6/1258	84/7206	0.00893639639584
ko04612	Antigen processing and presentation	5/1258	77/7206	0.0093914822327
ko04630	Jak-STAT signaling pathway	12/1258	132/7206	0.0103397403876
ko05166	HTLV-I infection	35/1258	292/7206	0.0115696271101
ko05131	Shigellosis	6/1258	82/7206	0.0122741560413
ko04115	p53 signaling pathway	5/1258	74/7206	0.0128507341189
ko04640	Hematopoietic cell lineage	4/1258	64/7206	0.0129131411567
ko04658	Th1 and Th2 cell differentiation	8/1258	96/7206	0.0145618911654
ko04711	Circadian rhythm - fly	6/1258	13/7206	0.0157558085894
ko04217	Necroptosis	19/1258	178/7206	0.0159463277342
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1258	100/7206	0.0162445627364
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1258	182/7206	0.0175557696202
ko04214	Apoptosis - fly	5/1258	72/7206	0.017962119945
ko04330	Notch signaling pathway	4/1258	62/7206	0.0180594223671
ko04922	Glucagon signaling pathway	33/1258	128/7206	0.0180638725684
ko04916	Melanogenesis	36/1258	142/7206	0.0183571473962
ko01524	Platinum drug resistance	6/1258	76/7206	0.022798778051
ko04620	Toll-like receptor signaling pathway	9/1258	100/7206	0.0235131613937
ko04270	Vascular smooth muscle contraction	38/1258	154/7206	0.023563479619
ko00562	Inositol phosphate metabolism	24/1258	89/7206	0.0236936642563
ko03320	PPAR signaling pathway	5/1258	69/7206	0.0244042009544
ko04668	TNF signaling pathway	12/1258	120/7206	0.0286875002186
ko05215	Prostate cancer	11/1258	111/7206	0.0322042097906
ko05222	Small cell lung cancer	8/1258	89/7206	0.0342939597574
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1258	40/7206	0.0355133527844
ko04015	Rap1 signaling pathway	62/1258	278/7206	0.0358132847276
ko05219	Bladder cancer	3/1258	48/7206	0.0360707193563
ko04210	Apoptosis	21/1258	180/7206	0.0367962740945
ko05231	Choline metabolism in cancer	33/1258	134/7206	0.0376976636784
ko04973	Carbohydrate digestion and absorption	13/1258	42/7206	0.0380436202462
ko04912	GnRH signaling pathway	30/1258	122/7206	0.0408343939015
ko00280	Valine, leucine and isoleucine degradation	4/1258	54/7206	0.048393441542
ko05340	Primary immunodeficiency	1/1258	30/7206	0.0494003254933