ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	118/664	423/7206	1.12219169538e-30
ko05033	Nicotine addiction	38/664	56/7206	7.16267003145e-27
ko04724	Glutamatergic synapse	62/664	152/7206	4.79862766576e-26
ko05032	Morphine addiction	43/664	110/7206	1.5761623539e-17
ko04713	Circadian entrainment	47/664	136/7206	1.52154574022e-16
ko04024	cAMP signaling pathway	71/664	279/7206	3.83434436155e-16
ko04727	GABAergic synapse	40/664	110/7206	4.07454982975e-15
ko04723	Retrograde endocannabinoid signaling	52/664	175/7206	4.89058417844e-15
ko04020	Calcium signaling pathway	66/664	265/7206	1.4279319409e-14
ko04728	Dopaminergic synapse	53/664	185/7206	1.43165037784e-14
ko04721	Synaptic vesicle cycle	31/664	80/7206	7.42343198058e-13
ko04921	Oxytocin signaling pathway	51/664	209/7206	3.83052625732e-11
ko04911	Insulin secretion	35/664	117/7206	1.32643179876e-10
ko04725	Cholinergic synapse	42/664	160/7206	1.89371242458e-10
ko04742	Taste transduction	23/664	61/7206	1.35265652781e-09
ko04726	Serotonergic synapse	36/664	137/7206	3.77330435017e-09
ko05031	Amphetamine addiction	28/664	91/7206	4.78151005829e-09
ko04261	Adrenergic signaling in cardiomyocytes	46/664	205/7206	8.48376868205e-09
ko04970	Salivary secretion	27/664	95/7206	5.9012164024e-08
ko04720	Long-term potentiation	27/664	99/7206	1.51055675527e-07
ko04010	MAPK signaling pathway	58/664	321/7206	4.91910805768e-07
ko04514	Cell adhesion molecules (CAMs)	30/664	130/7206	1.60075739511e-06
ko05030	Cocaine addiction	20/664	73/7206	5.77536103418e-06
ko04022	cGMP-PKG signaling pathway	41/664	216/7206	6.22990900794e-06
ko03040	Spliceosome	1/664	145/7206	1.72571279359e-05
ko04925	Aldosterone synthesis and secretion	24/664	105/7206	2.09052424615e-05
ko04070	Phosphatidylinositol signaling system	25/664	112/7206	2.18077877881e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	19/664	74/7206	2.71165799928e-05
ko04730	Long-term depression	19/664	78/7206	5.97194726234e-05
ko04260	Cardiac muscle contraction	22/664	98/7206	6.14304611753e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/664	79/7206	7.19961746274e-05
ko03010	Ribosome	1/664	129/7206	8.4273651914e-05
ko05203	Viral carcinogenesis	9/664	277/7206	0.000120870761943
ko04072	Phospholipase D signaling pathway	35/664	197/7206	0.000136776195964
ko05164	Influenza A	3/664	167/7206	0.000190458991659
ko04360	Axon guidance	39/664	233/7206	0.000196130389598
ko04971	Gastric acid secretion	21/664	98/7206	0.00025327600336
ko04120	Ubiquitin mediated proteolysis	2/664	138/7206	0.000284162685715
ko04060	Cytokine-cytokine receptor interaction	5/664	191/7206	0.000511611307641
ko05322	Systemic lupus erythematosus	3/664	151/7206	0.000533716980137
ko04972	Pancreatic secretion	22/664	111/7206	0.000665372713
ko05414	Dilated cardiomyopathy	22/664	112/7206	0.000701793863711
ko03013	RNA transport	4/664	166/7206	0.000922841016464
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/664	14/7206	0.000941501509963
ko05168	Herpes simplex infection	5/664	182/7206	0.000996147332814
ko05162	Measles	2/664	120/7206	0.00125352897294
ko04745	Phototransduction - fly	10/664	38/7206	0.00179661633301
ko05169	Epstein-Barr virus infection	7/664	206/7206	0.0019983863385
ko04630	Jak-STAT signaling pathway	3/664	132/7206	0.00218735140505
ko04141	Protein processing in endoplasmic reticulum	6/664	184/7206	0.00268151841876
ko04014	Ras signaling pathway	41/664	279/7206	0.00287696812616
ko04930	Type II diabetes mellitus	12/664	54/7206	0.00311506777546
ko04964	Proximal tubule bicarbonate reclamation	8/664	29/7206	0.00371559033431
ko00240	Pyrimidine metabolism	2/664	110/7206	0.00394853166473
ko05410	Hypertrophic cardiomyopathy (HCM)	18/664	100/7206	0.0047806527155
ko04621	NOD-like receptor signaling pathway	5/664	157/7206	0.00491177399154
ko04924	Renin secretion	16/664	86/7206	0.00705065204024
ko04540	Gap junction	21/664	128/7206	0.00808719825216
ko00562	Inositol phosphate metabolism	16/664	89/7206	0.00846866736848
ko04510	Focal adhesion	11/664	240/7206	0.00876759158742
ko05130	Pathogenic Escherichia coli infection	1/664	77/7206	0.00894305914334
ko04550	Signaling pathways regulating pluripotency of stem cells	6/664	165/7206	0.0090813509833
ko04961	Endocrine and other factor-regulated calcium reabsorption	12/664	59/7206	0.00990018085311
ko04960	Aldosterone-regulated sodium reabsorption	9/664	41/7206	0.01079421958
ko05215	Prostate cancer	3/664	111/7206	0.0121618768653
ko04214	Apoptosis - fly	1/664	72/7206	0.0130337220942
ko04710	Circadian rhythm	9/664	43/7206	0.0147304080193
ko05161	Hepatitis B	7/664	173/7206	0.0156982928081
ko04740	Olfactory transduction	14/664	80/7206	0.0175026318355
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/664	182/7206	0.0190546282112
ko04015	Rap1 signaling pathway	37/664	278/7206	0.0197946363175
ko04750	Inflammatory mediator regulation of TRP channels	19/664	122/7206	0.0251306890426
ko04978	Mineral absorption	8/664	40/7206	0.0270984728903
ko04110	Cell cycle	6/664	145/7206	0.0290462299688
ko05205	Proteoglycans in cancer	15/664	271/7206	0.031794468028
ko04064	NF-kappa B signaling pathway	3/664	96/7206	0.0325128849169
ko00680	Methane metabolism	7/664	34/7206	0.0325696813504
ko04371	Apelin signaling pathway	25/664	177/7206	0.0337970237743
ko04150	mTOR signaling pathway	9/664	184/7206	0.0383232983449
ko05140	Leishmaniasis	2/664	75/7206	0.0443101193352
ko01524	Platinum drug resistance	2/664	76/7206	0.04446085653
ko04217	Necroptosis	9/664	178/7206	0.0492445586166