ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 133/701 423/7206 2.73919901821e-38 ko05033 Nicotine addiction 42/701 56/7206 1.56954778022e-31 ko04724 Glutamatergic synapse 67/701 152/7206 4.21119405714e-29 ko05032 Morphine addiction 46/701 110/7206 3.96536088272e-19 ko04727 GABAergic synapse 45/701 110/7206 2.77266723592e-18 ko04024 cAMP signaling pathway 75/701 279/7206 4.12867247557e-17 ko04713 Circadian entrainment 47/701 136/7206 1.29908947699e-15 ko04723 Retrograde endocannabinoid signaling 54/701 175/7206 2.45797212481e-15 ko04728 Dopaminergic synapse 52/701 185/7206 5.38140449152e-13 ko04725 Cholinergic synapse 47/701 160/7206 1.28112925706e-12 ko04742 Taste transduction 26/701 61/7206 1.40613215692e-11 ko04911 Insulin secretion 37/701 117/7206 3.0982086704e-11 ko04721 Synaptic vesicle cycle 29/701 80/7206 1.09095153691e-10 ko04020 Calcium signaling pathway 60/701 265/7206 2.1704003989e-10 ko04726 Serotonergic synapse 38/701 137/7206 1.20966135454e-09 ko04744 Phototransduction 17/701 36/7206 7.56007687161e-09 ko05030 Cocaine addiction 25/701 73/7206 8.32024372841e-09 ko04921 Oxytocin signaling pathway 48/701 209/7206 8.57590767071e-09 ko05031 Amphetamine addiction 27/701 91/7206 6.78891652592e-08 ko04970 Salivary secretion 26/701 95/7206 6.90115389914e-07 ko05203 Viral carcinogenesis 6/701 277/7206 7.49343104164e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 22/701 74/7206 1.07877558664e-06 ko04972 Pancreatic secretion 28/701 111/7206 1.57519054697e-06 ko04720 Long-term potentiation 26/701 99/7206 1.63506252558e-06 ko04261 Adrenergic signaling in cardiomyocytes 42/701 205/7206 3.19049327392e-06 ko03040 Spliceosome 1/701 145/7206 1.17436998824e-05 ko05164 Influenza A 2/701 167/7206 1.40637871854e-05 ko04514 Cell adhesion molecules (CAMs) 29/701 130/7206 1.56593120014e-05 ko04010 MAPK signaling pathway 55/701 321/7206 2.72561045122e-05 ko04971 Gastric acid secretion 23/701 98/7206 4.67812941685e-05 ko03013 RNA transport 3/701 166/7206 8.71644988095e-05 ko04730 Long-term depression 19/701 78/7206 0.000124279873395 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/701 79/7206 0.000149058433599 ko04022 cGMP-PKG signaling pathway 39/701 216/7206 0.0001506046163 ko04060 Cytokine-cytokine receptor interaction 5/701 191/7206 0.000175643894936 ko04740 Olfactory transduction 19/701 80/7206 0.00017807790428 ko05205 Proteoglycans in cancer 10/701 271/7206 0.00022144814355 ko05322 Systemic lupus erythematosus 3/701 151/7206 0.000251773592888 ko04120 Ubiquitin mediated proteolysis 3/701 138/7206 0.000740126779762 ko05169 Epstein-Barr virus infection 7/701 206/7206 0.000750204168188 ko05162 Measles 2/701 120/7206 0.00086638748003 ko04964 Proximal tubule bicarbonate reclamation 9/701 29/7206 0.0012407071286 ko04925 Aldosterone synthesis and secretion 21/701 105/7206 0.00125035507383 ko04141 Protein processing in endoplasmic reticulum 6/701 184/7206 0.00141650851662 ko04924 Renin secretion 18/701 86/7206 0.00145104264211 ko04260 Cardiac muscle contraction 20/701 98/7206 0.00148873075137 ko04976 Bile secretion 17/701 80/7206 0.00174734668272 ko04217 Necroptosis 6/701 178/7206 0.00190394577884 ko04072 Phospholipase D signaling pathway 33/701 197/7206 0.00203691440538 ko04710 Circadian rhythm 11/701 43/7206 0.0021467652553 ko00190 Oxidative phosphorylation 3/701 127/7206 0.00215993852634 ko04621 NOD-like receptor signaling pathway 5/701 157/7206 0.00253368350276 ko04150 mTOR signaling pathway 7/701 184/7206 0.00351620705536 ko04540 Gap junction 23/701 128/7206 0.00366249386373 ko04630 Jak-STAT signaling pathway 4/701 132/7206 0.00464925603526 ko04932 Non-alcoholic fatty liver disease (NAFLD) 7/701 182/7206 0.00485312910061 ko04930 Type II diabetes mellitus 12/701 54/7206 0.00485755927738 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/701 59/7206 0.00604200254121 ko04110 Cell cycle 5/701 145/7206 0.00663221034179 ko05200 Pathways in cancer 31/701 492/7206 0.00717451667329 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/701 14/7206 0.00815012501926 ko05161 Hepatitis B 7/701 173/7206 0.00872949977624 ko05215 Prostate cancer 3/701 111/7206 0.00873042304847 ko05414 Dilated cardiomyopathy 20/701 112/7206 0.00894494335263 ko04146 Peroxisome 2/701 89/7206 0.0108203072838 ko04978 Mineral absorption 9/701 40/7206 0.0128550339155 ko04218 Cellular senescence 8/701 177/7206 0.014282146498 ko04960 Aldosterone-regulated sodium reabsorption 9/701 41/7206 0.0150928011042 ko04145 Phagosome 7/701 162/7206 0.0152576301762 ko03018 RNA degradation 2/701 84/7206 0.0153849051224 ko05218 Melanoma 2/701 85/7206 0.0154587852643 ko04350 TGF-beta signaling pathway 3/701 103/7206 0.0172909386666 ko04360 Axon guidance 34/701 233/7206 0.017511022291 ko05166 HTLV-I infection 17/701 292/7206 0.0200030999207 ko05211 Renal cell carcinoma 3/701 96/7206 0.0231763404554 ko04064 NF-kappa B signaling pathway 3/701 96/7206 0.0231763404554 ko04915 Estrogen signaling pathway 21/701 131/7206 0.023958756527 ko00330 Arginine and proline metabolism 1/701 61/7206 0.0276037394455 ko05168 Herpes simplex infection 9/701 182/7206 0.0300158388888 ko05140 Leishmaniasis 2/701 75/7206 0.0310107774292 ko04711 Circadian rhythm - fly 4/701 13/7206 0.0310952352755 ko05130 Pathogenic Escherichia coli infection 2/701 77/7206 0.031322191819 ko04612 Antigen processing and presentation 2/701 77/7206 0.031322191819 ko04610 Complement and coagulation cascades 2/701 79/7206 0.0325867991553 ko00240 Pyrimidine metabolism 4/701 110/7206 0.0328478212597 ko04510 Focal adhesion 14/701 240/7206 0.0353192029556 ko04142 Lysosome 7/701 151/7206 0.0358141946825 ko05410 Hypertrophic cardiomyopathy (HCM) 16/701 100/7206 0.0405444502516 ko04750 Inflammatory mediator regulation of TRP channels 19/701 122/7206 0.042895517301 ko05133 Pertussis 3/701 87/7206 0.0443620734803