ko pathway ratio_in_study ratio_in_pop p_value ko04726 Serotonergic synapse 30/561 137/7206 1.41031681692e-07 ko04070 Phosphatidylinositol signaling system 24/561 112/7206 3.80392999463e-06 ko04080 Neuroactive ligand-receptor interaction 59/561 423/7206 8.44393166046e-06 ko05032 Morphine addiction 22/561 110/7206 3.03665713007e-05 ko04721 Synaptic vesicle cycle 18/561 80/7206 3.09747280165e-05 ko04921 Oxytocin signaling pathway 34/561 209/7206 3.25959602627e-05 ko04744 Phototransduction 11/561 36/7206 5.73794913361e-05 ko04710 Circadian rhythm 12/561 43/7206 7.17387498169e-05 ko04020 Calcium signaling pathway 39/561 265/7206 9.16337872966e-05 ko04966 Collecting duct acid secretion 9/561 26/7206 9.23017358729e-05 ko05322 Systemic lupus erythematosus 1/561 151/7206 9.25472043568e-05 ko04024 cAMP signaling pathway 40/561 279/7206 0.000138014578487 ko04724 Glutamatergic synapse 26/561 152/7206 0.000155231229151 ko03040 Spliceosome 1/561 145/7206 0.000213080909958 ko04713 Circadian entrainment 23/561 136/7206 0.000482507329257 ko04745 Phototransduction - fly 10/561 38/7206 0.000483615530583 ko03010 Ribosome 1/561 129/7206 0.000669219691603 ko04727 GABAergic synapse 19/561 110/7206 0.000871639007303 ko04960 Aldosterone-regulated sodium reabsorption 10/561 41/7206 0.000927324267955 ko04925 Aldosterone synthesis and secretion 18/561 105/7206 0.0013056646474 ko04970 Salivary secretion 17/561 95/7206 0.00135699689748 ko04137 Mitophagy - animal 15/561 82/7206 0.00144789744394 ko04725 Cholinergic synapse 24/561 160/7206 0.0015367722234 ko00564 Glycerophospholipid metabolism 17/561 99/7206 0.00180030180261 ko04720 Long-term potentiation 17/561 99/7206 0.00180030180261 ko04136 Autophagy - other 8/561 31/7206 0.00203035777086 ko04911 Insulin secretion 19/561 117/7206 0.00237946948217 ko04728 Dopaminergic synapse 26/561 185/7206 0.00307504420968 ko04750 Inflammatory mediator regulation of TRP channels 19/561 122/7206 0.00316779392709 ko05033 Nicotine addiction 11/561 56/7206 0.00341500772521 ko04919 Thyroid hormone signaling pathway 21/561 143/7206 0.00407476165793 ko00051 Fructose and mannose metabolism 9/561 42/7206 0.00428527604154 ko04140 Autophagy - animal 23/561 164/7206 0.00480921573623 ko04138 Autophagy - yeast 14/561 81/7206 0.00492010301769 ko05203 Viral carcinogenesis 10/561 277/7206 0.00576456817435 ko04022 cGMP-PKG signaling pathway 28/561 216/7206 0.00648261608112 ko04922 Glucagon signaling pathway 19/561 128/7206 0.00659642472984 ko04110 Cell cycle 3/561 145/7206 0.00680145931472 ko04730 Long-term depression 13/561 78/7206 0.00844756900096 ko05110 Vibrio cholerae infection 11/561 63/7206 0.00861355809009 ko04626 Plant-pathogen interaction 5/561 18/7206 0.0102594649877 ko05230 Central carbon metabolism in cancer 13/561 81/7206 0.0105849885964 ko01040 Biosynthesis of unsaturated fatty acids 6/561 25/7206 0.0106850331898 ko05200 Pathways in cancer 24/561 492/7206 0.0112312657233 ko04390 Hippo signaling pathway 6/561 188/7206 0.0126563441323 ko00010 Glycolysis / Gluconeogenesis 12/561 74/7206 0.0135991446987 ko04657 IL-17 signaling pathway 1/561 87/7206 0.0138694604433 ko04510 Focal adhesion 9/561 240/7206 0.0139312144266 ko00680 Methane metabolism 7/561 34/7206 0.0141215601407 ko05031 Amphetamine addiction 14/561 91/7206 0.0154396748762 ko04014 Ras signaling pathway 33/561 279/7206 0.0159559294214 ko04152 AMPK signaling pathway 21/561 161/7206 0.0167477381084 ko00590 Arachidonic acid metabolism 9/561 52/7206 0.0176855371532 ko03008 Ribosome biogenesis in eukaryotes 1/561 79/7206 0.0198618743966 ko04650 Natural killer cell mediated cytotoxicity 14/561 97/7206 0.0207887818597 ko04723 Retrograde endocannabinoid signaling 22/561 175/7206 0.0218908735819 ko04964 Proximal tubule bicarbonate reclamation 6/561 29/7206 0.0220019357296 ko04971 Gastric acid secretion 14/561 98/7206 0.0220548468583 ko00562 Inositol phosphate metabolism 13/561 89/7206 0.0256454550769 ko00561 Glycerolipid metabolism 10/561 63/7206 0.0285436047749 ko05130 Pathogenic Escherichia coli infection 1/561 77/7206 0.0294226341443 ko05120 Epithelial cell signaling in Helicobacter pylori infection 13/561 92/7206 0.030036607693 ko05224 Breast cancer 6/561 174/7206 0.0303244128038 ko05166 HTLV-I infection 13/561 292/7206 0.0331335220462 ko05169 Epstein-Barr virus infection 8/561 206/7206 0.0337234049526 ko04141 Protein processing in endoplasmic reticulum 7/561 184/7206 0.0366139640541 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/561 191/7206 0.0383555424491 ko00230 Purine metabolism 23/561 194/7206 0.040409179471 ko04072 Phospholipase D signaling pathway 23/561 197/7206 0.0432526700184 ko04261 Adrenergic signaling in cardiomyocytes 24/561 205/7206 0.045653109112 ko04810 Regulation of actin cytoskeleton 12/561 264/7206 0.0459851316303 ko05168 Herpes simplex infection 7/561 182/7206 0.0482363584484