ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 140/790 423/7206 5.20812433655e-37 ko04724 Glutamatergic synapse 78/790 152/7206 6.03291353344e-36 ko05033 Nicotine addiction 40/790 56/7206 1.19970837748e-26 ko04713 Circadian entrainment 58/790 136/7206 1.03119379753e-21 ko05032 Morphine addiction 50/790 110/7206 2.43836656049e-20 ko04728 Dopaminergic synapse 67/790 185/7206 3.28511067221e-20 ko04727 GABAergic synapse 49/790 110/7206 1.72477898352e-19 ko04723 Retrograde endocannabinoid signaling 62/790 175/7206 3.22405924395e-18 ko04020 Calcium signaling pathway 78/790 265/7206 3.39407006831e-17 ko04720 Long-term potentiation 43/790 99/7206 9.62474722494e-17 ko04911 Insulin secretion 45/790 117/7206 4.67951821589e-15 ko04024 cAMP signaling pathway 75/790 279/7206 3.60629702906e-14 ko04726 Serotonergic synapse 48/790 137/7206 3.85329688186e-14 ko04725 Cholinergic synapse 52/790 160/7206 1.06056341078e-13 ko05031 Amphetamine addiction 37/790 91/7206 1.74267676128e-13 ko04921 Oxytocin signaling pathway 59/790 209/7206 2.18131890741e-12 ko04261 Adrenergic signaling in cardiomyocytes 58/790 205/7206 3.05471412144e-12 ko04970 Salivary secretion 34/790 95/7206 1.12899287368e-10 ko04721 Synaptic vesicle cycle 30/790 80/7206 3.8192040166e-10 ko04925 Aldosterone synthesis and secretion 35/790 105/7206 5.70426428462e-10 ko04971 Gastric acid secretion 32/790 98/7206 5.62470593753e-09 ko05030 Cocaine addiction 25/790 73/7206 9.24932413229e-08 ko04730 Long-term depression 26/790 78/7206 9.56706954067e-08 ko04070 Phosphatidylinositol signaling system 32/790 112/7206 1.97360644878e-07 ko04745 Phototransduction - fly 16/790 38/7206 8.12004529878e-07 ko04742 Taste transduction 21/790 61/7206 8.98333087296e-07 ko04750 Inflammatory mediator regulation of TRP channels 32/790 122/7206 2.23439995061e-06 ko04740 Olfactory transduction 24/790 80/7206 2.57765250342e-06 ko04010 MAPK signaling pathway 62/790 321/7206 5.94298950084e-06 ko04022 cGMP-PKG signaling pathway 46/790 216/7206 6.96152251258e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 22/790 74/7206 7.91383724265e-06 ko03010 Ribosome 1/790 129/7206 1.05602956645e-05 ko05168 Herpes simplex infection 4/790 182/7206 1.104228286e-05 ko03040 Spliceosome 2/790 145/7206 1.1743998604e-05 ko04744 Phototransduction 14/790 36/7206 1.21374885323e-05 ko04972 Pancreatic secretion 28/790 111/7206 1.8302945007e-05 ko04540 Gap junction 31/790 128/7206 1.90862241321e-05 ko04514 Cell adhesion molecules (CAMs) 31/790 130/7206 2.35115348063e-05 ko04060 Cytokine-cytokine receptor interaction 5/790 191/7206 2.88630707038e-05 ko05203 Viral carcinogenesis 11/790 277/7206 3.18551307481e-05 ko04260 Cardiac muscle contraction 25/790 98/7206 4.74336659009e-05 ko05164 Influenza A 4/790 167/7206 4.74641178239e-05 ko05162 Measles 2/790 120/7206 0.00017400782068 ko04072 Phospholipase D signaling pathway 39/790 197/7206 0.000190232961486 ko05322 Systemic lupus erythematosus 4/790 151/7206 0.000295323187753 ko04626 Plant-pathogen interaction 8/790 18/7206 0.00032238723438 ko04630 Jak-STAT signaling pathway 3/790 132/7206 0.000341493436516 ko05169 Epstein-Barr virus infection 8/790 206/7206 0.000386603544111 ko04110 Cell cycle 4/790 145/7206 0.00040267193547 ko04014 Ras signaling pathway 49/790 279/7206 0.00080559385251 ko04960 Aldosterone-regulated sodium reabsorption 12/790 41/7206 0.0010763714255 ko04360 Axon guidance 42/790 233/7206 0.00124330171211 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/790 59/7206 0.00135291624921 ko00562 Inositol phosphate metabolism 20/790 89/7206 0.00162827414255 ko04912 GnRH signaling pathway 25/790 122/7206 0.00182329031815 ko04924 Renin secretion 19/790 86/7206 0.00254572292773 ko04964 Proximal tubule bicarbonate reclamation 9/790 29/7206 0.00288000874544 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/790 79/7206 0.00290535217138 ko04114 Oocyte meiosis 27/790 139/7206 0.00350475635445 ko04973 Carbohydrate digestion and absorption 11/790 42/7206 0.0045038215111 ko04932 Non-alcoholic fatty liver disease (NAFLD) 9/790 182/7206 0.0055463835374 ko04141 Protein processing in endoplasmic reticulum 9/790 184/7206 0.00559195668381 ko05414 Dilated cardiomyopathy 22/790 112/7206 0.00562676233322 ko05214 Glioma 17/790 79/7206 0.00564402472007 ko04621 NOD-like receptor signaling pathway 7/790 157/7206 0.00618221436748 ko03013 RNA transport 8/790 166/7206 0.0078481047551 ko04918 Thyroid hormone synthesis 18/790 86/7206 0.00785117503177 ko04120 Ubiquitin mediated proteolysis 6/790 138/7206 0.00851320751206 ko00680 Methane metabolism 9/790 34/7206 0.00915062169163 ko04922 Glucagon signaling pathway 24/790 128/7206 0.00925091326995 ko03008 Ribosome biogenesis in eukaryotes 2/790 79/7206 0.0103475025467 ko05010 Alzheimer's disease 34/790 202/7206 0.0113522823067 ko04668 TNF signaling pathway 5/790 120/7206 0.011809536523 ko04270 Vascular smooth muscle contraction 27/790 154/7206 0.0126235883405 ko05161 Hepatitis B 9/790 173/7206 0.013016707644 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/790 14/7206 0.0134417866914 ko05410 Hypertrophic cardiomyopathy (HCM) 19/790 100/7206 0.0147459103399 ko05140 Leishmaniasis 2/790 75/7206 0.0147862862173 ko04146 Peroxisome 3/790 89/7206 0.0159968578844 ko05222 Small cell lung cancer 3/790 89/7206 0.0159968578844 ko05166 HTLV-I infection 20/790 292/7206 0.0212754971297 ko00310 Lysine degradation 2/790 73/7206 0.021648553689 ko00010 Glycolysis / Gluconeogenesis 15/790 74/7206 0.0222693550724 ko05132 Salmonella infection 4/790 98/7206 0.0224194694725 ko04710 Circadian rhythm 10/790 43/7206 0.0224210813374 ko04915 Estrogen signaling pathway 23/790 131/7206 0.0226388963514 ko04620 Toll-like receptor signaling pathway 4/790 100/7206 0.0226542358243 ko04657 IL-17 signaling pathway 3/790 87/7206 0.0228880185522 ko05110 Vibrio cholerae infection 13/790 63/7206 0.023081547345 ko05200 Pathways in cancer 39/790 492/7206 0.0247578399285 ko05231 Choline metabolism in cancer 23/790 134/7206 0.0253007793482 ko05418 Fluid shear stress and atherosclerosis 10/790 173/7206 0.0259078139463 ko05034 Alcoholism 37/790 238/7206 0.0263089726951 ko04371 Apelin signaling pathway 29/790 177/7206 0.0273249353347 ko00240 Pyrimidine metabolism 5/790 110/7206 0.0298189220071 ko05131 Shigellosis 3/790 82/7206 0.0312731742741 ko00512 Mucin type O-glycan biosynthesis 7/790 29/7206 0.0335505614024 ko04210 Apoptosis 11/790 180/7206 0.038817376166 ko00590 Arachidonic acid metabolism 1/790 52/7206 0.040518206868 ko04012 ErbB signaling pathway 19/790 109/7206 0.0424828355433 ko04640 Hematopoietic cell lineage 2/790 64/7206 0.0426534757557 ko04550 Signaling pathways regulating pluripotency of stem cells 10/790 165/7206 0.0428134361924 ko04610 Complement and coagulation cascades 3/790 79/7206 0.0438517560303