ko pathway ratio_in_study ratio_in_pop p_value ko04710 Circadian rhythm 8/181 43/7206 9.27841430583e-06 ko04713 Circadian entrainment 13/181 136/7206 3.35921392172e-05 ko04922 Glucagon signaling pathway 12/181 128/7206 8.20523306202e-05 ko04921 Oxytocin signaling pathway 15/181 209/7206 0.000229803945078 ko04925 Aldosterone synthesis and secretion 10/181 105/7206 0.000285174456034 ko00010 Glycolysis / Gluconeogenesis 8/181 74/7206 0.000496721599682 ko04725 Cholinergic synapse 12/181 160/7206 0.000662469002504 ko04138 Autophagy - yeast 8/181 81/7206 0.000913161557116 ko04066 HIF-1 signaling pathway 10/181 123/7206 0.00100490812124 ko01230 Biosynthesis of amino acids 8/181 85/7206 0.00125479138146 ko00680 Methane metabolism 5/181 34/7206 0.00145694461946 ko04911 Insulin secretion 9/181 117/7206 0.00262107364341 ko02010 ABC transporters 5/181 39/7206 0.00272445835789 ko04022 cGMP-PKG signaling pathway 13/181 216/7206 0.00299195669032 ko04010 MAPK signaling pathway 17/181 321/7206 0.00305097905313 ko04068 FoxO signaling pathway 11/181 167/7206 0.00312225730541 ko04137 Mitophagy - animal 7/181 82/7206 0.00437140740373 ko04136 Autophagy - other 4/181 31/7206 0.00713018542598 ko04970 Salivary secretion 7/181 95/7206 0.00968600803502 ko04724 Glutamatergic synapse 9/181 152/7206 0.0141161050476 ko04915 Estrogen signaling pathway 8/181 131/7206 0.0170608800481 ko04213 Longevity regulating pathway - multiple species 6/181 86/7206 0.0207144338086 ko00220 Arginine biosynthesis 3/181 24/7206 0.0214060262822 ko04917 Prolactin signaling pathway 6/181 87/7206 0.0218005368826 ko04070 Phosphatidylinositol signaling system 7/181 112/7206 0.0223152661008 ko04013 MAPK signaling pathway - fly 7/181 115/7206 0.0253655114877 ko04024 cAMP signaling pathway 13/181 279/7206 0.0291772848766 ko04971 Gastric acid secretion 6/181 98/7206 0.0363528382385 ko04261 Adrenergic signaling in cardiomyocytes 10/181 205/7206 0.0384500531879 ko04711 Circadian rhythm - fly 2/181 13/7206 0.040807062356 ko01200 Carbon metabolism 7/181 128/7206 0.0418714059291 ko04020 Calcium signaling pathway 12/181 265/7206 0.0428586027142 ko04923 Regulation of lipolysis in adipocytes 5/181 77/7206 0.043772242666 ko04371 Apelin signaling pathway 9/181 177/7206 0.0443891730378 ko04730 Long-term depression 5/181 78/7206 0.0458578075544 ko04930 Type II diabetes mellitus 4/181 54/7206 0.0460308497399