ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	220/1338	423/7206	3.53525055825e-58
ko04724	Glutamatergic synapse	94/1338	152/7206	9.57810268496e-33
ko05033	Nicotine addiction	50/1338	56/7206	1.30309273473e-30
ko05032	Morphine addiction	72/1338	110/7206	1.49448040444e-27
ko04713	Circadian entrainment	81/1338	136/7206	1.0016827335e-26
ko04727	GABAergic synapse	71/1338	110/7206	1.27624318351e-26
ko04721	Synaptic vesicle cycle	55/1338	80/7206	6.86966578978e-23
ko04020	Calcium signaling pathway	114/1338	265/7206	7.67283285038e-21
ko04725	Cholinergic synapse	81/1338	160/7206	1.78739540438e-20
ko04728	Dopaminergic synapse	89/1338	185/7206	1.8434946711e-20
ko04911	Insulin secretion	64/1338	117/7206	1.16434530715e-18
ko04723	Retrograde endocannabinoid signaling	81/1338	175/7206	1.93144355043e-17
ko04024	cAMP signaling pathway	110/1338	279/7206	1.25259712207e-16
ko04921	Oxytocin signaling pathway	88/1338	209/7206	1.25186057191e-15
ko04742	Taste transduction	39/1338	61/7206	5.90242103604e-15
ko04726	Serotonergic synapse	64/1338	137/7206	2.89578921804e-14
ko04970	Salivary secretion	48/1338	95/7206	1.37250473097e-12
ko04720	Long-term potentiation	49/1338	99/7206	2.16628925719e-12
ko04744	Phototransduction	26/1338	36/7206	2.92816377023e-12
ko04261	Adrenergic signaling in cardiomyocytes	80/1338	205/7206	3.63408660855e-12
ko03040	Spliceosome	1/1338	145/7206	5.61340715432e-12
ko04360	Axon guidance	87/1338	233/7206	7.24971061935e-12
ko05031	Amphetamine addiction	45/1338	91/7206	1.80776099625e-11
ko04740	Olfactory transduction	38/1338	80/7206	2.94546538936e-09
ko04022	cGMP-PKG signaling pathway	76/1338	216/7206	3.96979630804e-09
ko05203	Viral carcinogenesis	18/1338	277/7206	5.76830791496e-09
ko04925	Aldosterone synthesis and secretion	45/1338	105/7206	6.65046166885e-09
ko05168	Herpes simplex infection	8/1338	182/7206	1.87181985072e-08
ko03013	RNA transport	7/1338	166/7206	4.68961768869e-08
ko04540	Gap junction	50/1338	128/7206	5.14972125016e-08
ko04060	Cytokine-cytokine receptor interaction	10/1338	191/7206	7.8364911078e-08
ko04971	Gastric acid secretion	40/1338	98/7206	2.55110814154e-07
ko05322	Systemic lupus erythematosus	7/1338	151/7206	6.82000006194e-07
ko05030	Cocaine addiction	32/1338	73/7206	8.11422065383e-07
ko04141	Protein processing in endoplasmic reticulum	11/1338	184/7206	1.06585035404e-06
ko04924	Renin secretion	35/1338	86/7206	1.74539464789e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1338	74/7206	2.83179524932e-06
ko04610	Complement and coagulation cascades	1/1338	79/7206	2.90855482555e-06
ko04010	MAPK signaling pathway	93/1338	321/7206	3.21872803057e-06
ko05164	Influenza A	10/1338	167/7206	4.11874478219e-06
ko04730	Long-term depression	32/1338	78/7206	5.00459285905e-06
ko04966	Collecting duct acid secretion	15/1338	26/7206	9.7900500336e-06
ko04972	Pancreatic secretion	40/1338	111/7206	1.11999656127e-05
ko04070	Phosphatidylinositol signaling system	40/1338	112/7206	1.34238853986e-05
ko04621	NOD-like receptor signaling pathway	10/1338	157/7206	1.59350418534e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1338	59/7206	2.41334312986e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1338	79/7206	2.80016549109e-05
ko04976	Bile secretion	31/1338	80/7206	3.00277235011e-05
ko04371	Apelin signaling pathway	55/1338	177/7206	4.96766557436e-05
ko04260	Cardiac muscle contraction	35/1338	98/7206	6.00032819036e-05
ko04072	Phospholipase D signaling pathway	59/1338	197/7206	8.36537596052e-05
ko04110	Cell cycle	10/1338	145/7206	8.48222433108e-05
ko05169	Epstein-Barr virus infection	18/1338	206/7206	8.48580298962e-05
ko04120	Ubiquitin mediated proteolysis	9/1338	138/7206	8.65513424058e-05
ko05110	Vibrio cholerae infection	25/1338	63/7206	0.000106235610501
ko04745	Phototransduction - fly	17/1338	38/7206	0.000184203882778
ko05140	Leishmaniasis	3/1338	75/7206	0.000282430339529
ko04014	Ras signaling pathway	76/1338	279/7206	0.000283728111984
ko04612	Antigen processing and presentation	3/1338	77/7206	0.000296142519967
ko05162	Measles	8/1338	120/7206	0.000318687548279
ko00520	Amino sugar and nucleotide sugar metabolism	1/1338	55/7206	0.00032835996565
ko04514	Cell adhesion molecules (CAMs)	41/1338	130/7206	0.000352806834452
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1338	79/7206	0.000364018430038
ko00240	Pyrimidine metabolism	7/1338	110/7206	0.000445778642767
ko05414	Dilated cardiomyopathy	36/1338	112/7206	0.000513959162144
ko04657	IL-17 signaling pathway	5/1338	87/7206	0.000783032635527
ko04146	Peroxisome	5/1338	89/7206	0.00081395154776
ko04064	NF-kappa B signaling pathway	6/1338	96/7206	0.000826468818662
ko04750	Inflammatory mediator regulation of TRP channels	38/1338	122/7206	0.000873261083381
ko05205	Proteoglycans in cancer	31/1338	271/7206	0.00141716464304
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1338	14/7206	0.00143163323318
ko05321	Inflammatory bowel disease (IBD)	2/1338	56/7206	0.0015732271033
ko03018	RNA degradation	5/1338	84/7206	0.00161920922887
ko04923	Regulation of lipolysis in adipocytes	26/1338	77/7206	0.00162813346501
ko05144	Malaria	1/1338	45/7206	0.00170685490604
ko00071	Fatty acid degradation	1/1338	45/7206	0.00170685490604
ko03420	Nucleotide excision repair	1/1338	46/7206	0.00175874657754
ko04640	Hematopoietic cell lineage	3/1338	64/7206	0.00190055109695
ko04214	Apoptosis - fly	4/1338	72/7206	0.00212058605477
ko00480	Glutathione metabolism	2/1338	55/7206	0.00245750765898
ko03022	Basal transcription factors	1/1338	44/7206	0.00271010471514
ko04622	RIG-I-like receptor signaling pathway	3/1338	62/7206	0.00276879605309
ko04916	Melanogenesis	41/1338	142/7206	0.00300204041485
ko04915	Estrogen signaling pathway	38/1338	131/7206	0.00306203705754
ko05133	Pertussis	6/1338	87/7206	0.00321841590469
ko00590	Arachidonic acid metabolism	2/1338	52/7206	0.00350270215974
ko05161	Hepatitis B	18/1338	173/7206	0.0039554101101
ko00330	Arginine and proline metabolism	3/1338	61/7206	0.00418918839784
ko04270	Vascular smooth muscle contraction	43/1338	154/7206	0.00440328119763
ko00630	Glyoxylate and dicarboxylate metabolism	1/1338	38/7206	0.00596864708404
ko03410	Base excision repair	1/1338	38/7206	0.00596864708404
ko05131	Shigellosis	6/1338	82/7206	0.00617938124537
ko04964	Proximal tubule bicarbonate reclamation	12/1338	29/7206	0.00619590359956
ko04115	p53 signaling pathway	5/1338	74/7206	0.00627874410878
ko04918	Thyroid hormone synthesis	26/1338	86/7206	0.00770393773282
ko04658	Th1 and Th2 cell differentiation	8/1338	96/7206	0.0077182142333
ko00260	Glycine, serine and threonine metabolism	2/1338	48/7206	0.00780676722254
ko04626	Plant-pathogen interaction	8/1338	18/7206	0.010335004923
ko04217	Necroptosis	20/1338	178/7206	0.0107779300667
ko04015	Rap1 signaling pathway	68/1338	278/7206	0.0117856353884
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1338	182/7206	0.0118826485307
ko04912	GnRH signaling pathway	34/1338	122/7206	0.0130103357511
ko04620	Toll-like receptor signaling pathway	9/1338	100/7206	0.0130960848957
ko00500	Starch and sucrose metabolism	1/1338	35/7206	0.0141565865999
ko04922	Glucagon signaling pathway	35/1338	128/7206	0.0153558459087
ko01524	Platinum drug resistance	6/1338	76/7206	0.0164891985125
ko05418	Fluid shear stress and atherosclerosis	20/1338	173/7206	0.0170566776639
ko00380	Tryptophan metabolism	3/1338	50/7206	0.0172152609269
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1338	26/7206	0.0186661612949
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1338	100/7206	0.0192298168116
ko00310	Lysine degradation	6/1338	73/7206	0.0221145572286
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1338	40/7206	0.023618222974
ko05145	Toxoplasmosis	14/1338	126/7206	0.0279653325993
ko01200	Carbon metabolism	14/1338	128/7206	0.0284679114443
ko04113	Meiosis - yeast	6/1338	70/7206	0.0297709497564
ko05320	Autoimmune thyroid disease	1/1338	29/7206	0.0308492920795
ko04630	Jak-STAT signaling pathway	15/1338	132/7206	0.0314414440755
ko05231	Choline metabolism in cancer	35/1338	134/7206	0.0322608199457
ko00280	Valine, leucine and isoleucine degradation	4/1338	54/7206	0.0338974132945
ko04142	Lysosome	18/1338	151/7206	0.0340301593762
ko00982	Drug metabolism - cytochrome P450	2/1338	37/7206	0.0343468651389
ko00620	Pyruvate metabolism	3/1338	46/7206	0.0349606134741
ko05132	Salmonella infection	10/1338	98/7206	0.0352905996062
ko05215	Prostate cancer	12/1338	111/7206	0.0357702738027
ko03320	PPAR signaling pathway	6/1338	69/7206	0.0412894791104
ko04973	Carbohydrate digestion and absorption	13/1338	42/7206	0.0461891759245
ko04975	Fat digestion and absorption	2/1338	35/7206	0.0496347601304