ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1120	423/7206	7.78725566889e-54
ko04724	Glutamatergic synapse	87/1120	152/7206	7.73171992243e-33
ko05033	Nicotine addiction	47/1120	56/7206	7.95671517383e-30
ko05032	Morphine addiction	66/1120	110/7206	8.96723802845e-27
ko04713	Circadian entrainment	73/1120	136/7206	2.62741674956e-25
ko04727	GABAergic synapse	64/1120	110/7206	6.15163988414e-25
ko04728	Dopaminergic synapse	86/1120	185/7206	6.241377353e-24
ko04721	Synaptic vesicle cycle	51/1120	80/7206	1.15505180157e-22
ko04725	Cholinergic synapse	76/1120	160/7206	5.66744539551e-22
ko04723	Retrograde endocannabinoid signaling	77/1120	175/7206	1.00384921809e-19
ko04020	Calcium signaling pathway	100/1120	265/7206	2.382710593e-19
ko04742	Taste transduction	39/1120	61/7206	1.11810315371e-17
ko04726	Serotonergic synapse	62/1120	137/7206	7.94761251429e-17
ko04024	cAMP signaling pathway	99/1120	279/7206	8.21055003207e-17
ko04921	Oxytocin signaling pathway	81/1120	209/7206	1.15853367084e-16
ko04911	Insulin secretion	55/1120	117/7206	5.8435513496e-16
ko04720	Long-term potentiation	46/1120	99/7206	2.54000398276e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1120	205/7206	1.05825396302e-12
ko05031	Amphetamine addiction	42/1120	91/7206	3.72961422709e-12
ko04970	Salivary secretion	43/1120	95/7206	4.67013520779e-12
ko03040	Spliceosome	1/1120	145/7206	8.33982380406e-10
ko04744	Phototransduction	21/1120	36/7206	4.70075188412e-09
ko04360	Axon guidance	69/1120	233/7206	3.32560205681e-08
ko04022	cGMP-PKG signaling pathway	65/1120	216/7206	4.99685084808e-08
ko04925	Aldosterone synthesis and secretion	39/1120	105/7206	6.20919943691e-08
ko04740	Olfactory transduction	32/1120	80/7206	9.85561454828e-08
ko05168	Herpes simplex infection	6/1120	182/7206	1.25409122473e-07
ko04010	MAPK signaling pathway	85/1120	321/7206	2.31039322108e-07
ko04060	Cytokine-cytokine receptor interaction	7/1120	191/7206	2.37865659694e-07
ko04971	Gastric acid secretion	36/1120	98/7206	2.61521912519e-07
ko05030	Cocaine addiction	29/1120	73/7206	4.66217191097e-07
ko05203	Viral carcinogenesis	16/1120	277/7206	6.7376366748e-07
ko04540	Gap junction	42/1120	128/7206	8.45185513055e-07
ko04120	Ubiquitin mediated proteolysis	4/1120	138/7206	2.24572853575e-06
ko05164	Influenza A	7/1120	167/7206	4.22812075095e-06
ko03013	RNA transport	7/1120	166/7206	6.12905689158e-06
ko04966	Collecting duct acid secretion	14/1120	26/7206	6.79240217868e-06
ko04924	Renin secretion	30/1120	86/7206	7.59146955792e-06
ko04730	Long-term depression	28/1120	78/7206	9.43710956296e-06
ko05322	Systemic lupus erythematosus	6/1120	151/7206	1.10448041359e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1120	74/7206	1.13248616727e-05
ko04514	Cell adhesion molecules (CAMs)	40/1120	130/7206	1.21109169487e-05
ko04621	NOD-like receptor signaling pathway	7/1120	157/7206	1.74781846373e-05
ko04745	Phototransduction - fly	17/1120	38/7206	1.77641703638e-05
ko04070	Phosphatidylinositol signaling system	35/1120	112/7206	2.95488795336e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1120	79/7206	3.24693376502e-05
ko04612	Antigen processing and presentation	1/1120	77/7206	5.02198673162e-05
ko04972	Pancreatic secretion	34/1120	111/7206	5.31045585009e-05
ko04610	Complement and coagulation cascades	1/1120	79/7206	5.42488156716e-05
ko04371	Apelin signaling pathway	48/1120	177/7206	5.69565602148e-05
ko04260	Cardiac muscle contraction	31/1120	98/7206	5.704482721e-05
ko05110	Vibrio cholerae infection	23/1120	63/7206	5.89204114688e-05
ko04141	Protein processing in endoplasmic reticulum	11/1120	184/7206	7.96391400904e-05
ko04110	Cell cycle	7/1120	145/7206	0.000103547179293
ko04072	Phospholipase D signaling pathway	51/1120	197/7206	0.000134119409697
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1120	59/7206	0.000164747888242
ko05414	Dilated cardiomyopathy	33/1120	112/7206	0.000176411472269
ko05169	Epstein-Barr virus infection	14/1120	206/7206	0.000183836145734
ko04014	Ras signaling pathway	67/1120	279/7206	0.00018716964152
ko04750	Inflammatory mediator regulation of TRP channels	35/1120	122/7206	0.000202296417174
ko03008	Ribosome biogenesis in eukaryotes	2/1120	79/7206	0.000426166073629
ko05140	Leishmaniasis	2/1120	75/7206	0.00059390751285
ko04915	Estrogen signaling pathway	35/1120	131/7206	0.000891968261633
ko04064	NF-kappa B signaling pathway	4/1120	96/7206	0.000901242328799
ko04976	Bile secretion	24/1120	80/7206	0.000930508575332
ko04146	Peroxisome	4/1120	89/7206	0.00177074815745
ko05162	Measles	7/1120	120/7206	0.002019196348
ko00480	Glutathione metabolism	1/1120	55/7206	0.00213281234991
ko05205	Proteoglycans in cancer	25/1120	271/7206	0.00266459449497
ko00590	Arachidonic acid metabolism	1/1120	52/7206	0.00314415033643
ko04626	Plant-pathogen interaction	8/1120	18/7206	0.00337895713372
ko00330	Arginine and proline metabolism	2/1120	61/7206	0.004041655609
ko04330	Notch signaling pathway	2/1120	62/7206	0.004110910108
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1120	182/7206	0.00486977351355
ko00240	Pyrimidine metabolism	7/1120	110/7206	0.00502862288056
ko04912	GnRH signaling pathway	31/1120	122/7206	0.00507680691419
ko05161	Hepatitis B	14/1120	173/7206	0.00541893282962
ko05144	Malaria	1/1120	45/7206	0.00689627563618
ko00071	Fatty acid degradation	1/1120	45/7206	0.00689627563618
ko03420	Nucleotide excision repair	1/1120	46/7206	0.00690602019709
ko04657	IL-17 signaling pathway	5/1120	87/7206	0.00719617716613
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1120	100/7206	0.00752231941501
ko05321	Inflammatory bowel disease (IBD)	2/1120	56/7206	0.00862572313878
ko04964	Proximal tubule bicarbonate reclamation	10/1120	29/7206	0.0093906715149
ko01524	Platinum drug resistance	4/1120	76/7206	0.0100196404618
ko04630	Jak-STAT signaling pathway	10/1120	132/7206	0.0102599092996
ko03022	Basal transcription factors	1/1120	44/7206	0.0105078014579
ko00562	Inositol phosphate metabolism	23/1120	89/7206	0.0114592972853
ko04217	Necroptosis	16/1120	178/7206	0.0118506427124
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1120	14/7206	0.0135985297042
ko05131	Shigellosis	5/1120	82/7206	0.0137054748359
ko04916	Melanogenesis	33/1120	142/7206	0.0137977423966
ko04640	Hematopoietic cell lineage	3/1120	64/7206	0.0138580480976
ko04214	Apoptosis - fly	4/1120	72/7206	0.0138954084914
ko00310	Lysine degradation	4/1120	73/7206	0.0139540118643
ko03018	RNA degradation	5/1120	84/7206	0.014169225391
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1120	40/7206	0.0153237197189
ko00140	Steroid hormone biosynthesis	1/1120	41/7206	0.0155012559422
ko05166	HTLV-I infection	31/1120	292/7206	0.0166059877807
ko05145	Toxoplasmosis	10/1120	126/7206	0.0176004933151
ko04270	Vascular smooth muscle contraction	35/1120	154/7206	0.0176691999308
ko04015	Rap1 signaling pathway	58/1120	278/7206	0.0177124854224
ko00380	Tryptophan metabolism	2/1120	50/7206	0.018081309403
ko04922	Glucagon signaling pathway	30/1120	128/7206	0.0185773314837
ko05418	Fluid shear stress and atherosclerosis	16/1120	173/7206	0.0191206467197
ko04622	RIG-I-like receptor signaling pathway	3/1120	62/7206	0.0201278389613
ko05231	Choline metabolism in cancer	31/1120	134/7206	0.0213364415335
ko04930	Type II diabetes mellitus	15/1120	54/7206	0.0214624525513
ko05034	Alcoholism	50/1120	238/7206	0.0225627794201
ko00982	Drug metabolism - cytochrome P450	1/1120	37/7206	0.0228705280715
ko05133	Pertussis	6/1120	87/7206	0.0244308338905
ko00270	Cysteine and methionine metabolism	2/1120	47/7206	0.0261246221059
ko00260	Glycine, serine and threonine metabolism	2/1120	48/7206	0.0262417318963
ko04350	TGF-beta signaling pathway	8/1120	103/7206	0.0275717694648
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1120	92/7206	0.0300432113826
ko04114	Oocyte meiosis	31/1120	139/7206	0.0327153995675
ko00500	Starch and sucrose metabolism	1/1120	35/7206	0.0339123433533
ko04115	p53 signaling pathway	5/1120	74/7206	0.0350935537779
ko04620	Toll-like receptor signaling pathway	8/1120	100/7206	0.0362623277892
ko04210	Apoptosis	18/1120	180/7206	0.0369730791609
ko04923	Regulation of lipolysis in adipocytes	19/1120	77/7206	0.0378906001141
ko00280	Valine, leucine and isoleucine degradation	3/1120	54/7206	0.0381223863728
ko00620	Pyruvate metabolism	2/1120	46/7206	0.0383573339465
ko05214	Glioma	19/1120	79/7206	0.0420673632453
ko05016	Huntington's disease	23/1120	215/7206	0.0449383676414
ko04722	Neurotrophin signaling pathway	34/1120	160/7206	0.0472383007585
ko04658	Th1 and Th2 cell differentiation	8/1120	96/7206	0.0474283113272