ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 46/351 191/7206 1.85743817629e-20 ko04380 Osteoclast differentiation 33/351 134/7206 3.13860358518e-15 ko04621 NOD-like receptor signaling pathway 35/351 157/7206 1.16755332133e-14 ko05340 Primary immunodeficiency 15/351 30/7206 1.22391813239e-12 ko04064 NF-kappa B signaling pathway 25/351 96/7206 2.11403527045e-12 ko04650 Natural killer cell mediated cytotoxicity 24/351 97/7206 1.95148570504e-11 ko05164 Influenza A 31/351 167/7206 6.70048343659e-11 ko05140 Leishmaniasis 20/351 75/7206 2.27428155071e-10 ko04620 Toll-like receptor signaling pathway 23/351 100/7206 2.55256978344e-10 ko05162 Measles 25/351 120/7206 4.0023906016e-10 ko05321 Inflammatory bowel disease (IBD) 17/351 56/7206 5.73004384045e-10 ko05145 Toxoplasmosis 25/351 126/7206 1.188309735e-09 ko05152 Tuberculosis 31/351 187/7206 1.28017528544e-09 ko05168 Herpes simplex infection 30/351 182/7206 2.75830400916e-09 ko04660 T cell receptor signaling pathway 24/351 124/7206 4.35667417892e-09 ko04217 Necroptosis 29/351 178/7206 6.77151257892e-09 ko05150 Staphylococcus aureus infection 12/351 36/7206 6.42044306868e-08 ko05330 Allograft rejection 10/351 24/7206 7.04548190106e-08 ko04672 Intestinal immune network for IgA production 12/351 37/7206 9.09053911718e-08 ko04659 Th17 cell differentiation 20/351 106/7206 1.36931647096e-07 ko04640 Hematopoietic cell lineage 15/351 64/7206 2.75362767616e-07 ko05320 Autoimmune thyroid disease 10/351 29/7206 5.77905471913e-07 ko05332 Graft-versus-host disease 8/351 18/7206 8.34005827346e-07 ko04610 Complement and coagulation cascades 16/351 79/7206 9.2684828549e-07 ko04658 Th1 and Th2 cell differentiation 17/351 96/7206 3.03893401464e-06 ko04612 Antigen processing and presentation 15/351 77/7206 3.41063604613e-06 ko04062 Chemokine signaling pathway 26/351 201/7206 4.21419999798e-06 ko04630 Jak-STAT signaling pathway 20/351 132/7206 5.10471094426e-06 ko04622 RIG-I-like receptor signaling pathway 13/351 62/7206 6.59292163376e-06 ko05144 Malaria 11/351 45/7206 7.13280876005e-06 ko05161 Hepatitis B 23/351 173/7206 9.67075707043e-06 ko05142 Chagas disease (American trypanosomiasis) 19/351 130/7206 1.50019840165e-05 ko05133 Pertussis 15/351 87/7206 1.63019590472e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/351 191/7206 1.6368476115e-05 ko04662 B cell receptor signaling pathway 14/351 88/7206 7.84925593993e-05 ko05323 Rheumatoid arthritis 14/351 89/7206 8.91082719883e-05 ko05310 Asthma 6/351 17/7206 0.000100222723803 ko04940 Type I diabetes mellitus 8/351 32/7206 0.000109892481154 ko04623 Cytosolic DNA-sensing pathway 9/351 41/7206 0.000121981164166 ko04210 Apoptosis 21/351 180/7206 0.000163692605717 ko04145 Phagosome 19/351 162/7206 0.000311825445066 ko04137 Mitophagy - animal 12/351 82/7206 0.000559624727038 ko04664 Fc epsilon RI signaling pathway 11/351 77/7206 0.00115864574226 ko04611 Platelet activation 18/351 163/7206 0.00118561993959 ko05160 Hepatitis C 17/351 153/7206 0.00162627962739 ko05166 HTLV-I infection 26/351 292/7206 0.00307588205558 ko00590 Arachidonic acid metabolism 8/351 52/7206 0.00335838707582 ko03050 Proteasome 8/351 54/7206 0.00426722649843 ko05202 Transcriptional misregulation in cancer 18/351 188/7206 0.00532308998651 ko04514 Cell adhesion molecules (CAMs) 14/351 130/7206 0.00561284483457 ko04724 Glutamatergic synapse 1/351 152/7206 0.00703209800859 ko04668 TNF signaling pathway 13/351 120/7206 0.00778766729463 ko05132 Salmonella infection 11/351 98/7206 0.0078249867693 ko04666 Fc gamma R-mediated phagocytosis 13/351 122/7206 0.00836628044633 ko04670 Leukocyte transendothelial migration 15/351 151/7206 0.0109371678904 ko05418 Fluid shear stress and atherosclerosis 16/351 173/7206 0.0115721039611 ko04310 Wnt signaling pathway 2/351 181/7206 0.0127624254563 ko04713 Circadian entrainment 1/351 136/7206 0.0147782939981 ko05416 Viral myocarditis 7/351 55/7206 0.0165800223567 ko05131 Shigellosis 9/351 82/7206 0.0177064986841 ko04910 Insulin signaling pathway 2/351 172/7206 0.017900351164 ko05224 Breast cancer 2/351 174/7206 0.0182938674454 ko04922 Glucagon signaling pathway 1/351 128/7206 0.0213671494392 ko03010 Ribosome 1/351 129/7206 0.0214430101815 ko04152 AMPK signaling pathway 2/351 161/7206 0.0247657771206 ko05134 Legionellosis 8/351 74/7206 0.0267397210937 ko01524 Platinum drug resistance 8/351 76/7206 0.030787225984 ko05016 Huntington's disease 4/351 215/7206 0.0351042659109 ko04390 Hippo signaling pathway 3/351 188/7206 0.0366998262034 ko04144 Endocytosis 25/351 342/7206 0.038673120056 ko04072 Phospholipase D signaling pathway 16/351 197/7206 0.0419070410283 ko05032 Morphine addiction 1/351 110/7206 0.0442810778136 ko04360 Axon guidance 5/351 233/7206 0.0444864885771 ko00480 Glutathione metabolism 6/351 55/7206 0.049819492478