ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 62/531 145/7206 4.73170062301e-33 ko03050 Proteasome 25/531 54/7206 6.25377459462e-15 ko03030 DNA replication 20/531 38/7206 1.51416018822e-13 ko03008 Ribosome biogenesis in eukaryotes 28/531 79/7206 5.23512086085e-13 ko04080 Neuroactive ligand-receptor interaction 2/531 423/7206 3.92310911547e-12 ko03013 RNA transport 40/531 166/7206 8.89729399034e-12 ko04110 Cell cycle 31/531 145/7206 4.40882151349e-08 ko03410 Base excision repair 13/531 38/7206 1.58935924665e-06 ko03015 mRNA surveillance pathway 21/531 93/7206 2.70192186913e-06 ko03420 Nucleotide excision repair 14/531 46/7206 3.10643016752e-06 ko00240 Pyrimidine metabolism 22/531 110/7206 1.28561460159e-05 ko05169 Epstein-Barr virus infection 32/531 206/7206 5.71689784671e-05 ko04020 Calcium signaling pathway 5/531 265/7206 0.00010086633232 ko03430 Mismatch repair 8/531 22/7206 0.000104448596916 ko03440 Homologous recombination 11/531 41/7206 0.000129292366708 ko03460 Fanconi anemia pathway 12/531 51/7206 0.000251150632245 ko03018 RNA degradation 16/531 84/7206 0.000349063948069 ko05012 Parkinson's disease 2/531 155/7206 0.000948240465009 ko03010 Ribosome 1/531 129/7206 0.000975331927939 ko03060 Protein export 7/531 23/7206 0.000980854091461 ko00190 Oxidative phosphorylation 1/531 127/7206 0.00153630352765 ko04141 Protein processing in endoplasmic reticulum 25/531 184/7206 0.00244710600441 ko04070 Phosphatidylinositol signaling system 1/531 112/7206 0.0030573995224 ko05010 Alzheimer's disease 5/531 202/7206 0.00381562836785 ko03020 RNA polymerase 7/531 29/7206 0.00424195941256 ko04659 Th17 cell differentiation 1/531 106/7206 0.0044648409378 ko04330 Notch signaling pathway 11/531 62/7206 0.00507447241233 ko00230 Purine metabolism 25/531 194/7206 0.00509995045486 ko01200 Carbon metabolism 2/531 128/7206 0.00575997161757 ko04111 Cell cycle - yeast 14/531 90/7206 0.00675819393052 ko04218 Cellular senescence 23/531 177/7206 0.00783908036199 ko04974 Protein digestion and absorption 1/531 96/7206 0.00952549201299 ko04115 p53 signaling pathway 12/531 74/7206 0.0107268424353 ko04932 Non-alcoholic fatty liver disease (NAFLD) 5/531 182/7206 0.0134832067185 ko05323 Rheumatoid arthritis 1/531 89/7206 0.0138341853445 ko00562 Inositol phosphate metabolism 1/531 89/7206 0.0138341853445 ko04727 GABAergic synapse 2/531 110/7206 0.0165363855096 ko05032 Morphine addiction 2/531 110/7206 0.0165363855096 ko04113 Meiosis - yeast 11/531 70/7206 0.0172756385294 ko04630 Jak-STAT signaling pathway 3/531 132/7206 0.0177928086987 ko04723 Retrograde endocannabinoid signaling 5/531 175/7206 0.0179899784545 ko04724 Glutamatergic synapse 4/531 152/7206 0.0180926289062 ko03450 Non-homologous end-joining 4/531 15/7206 0.0206936618474 ko04350 TGF-beta signaling pathway 14/531 103/7206 0.0216354142339 ko05166 HTLV-I infection 32/531 292/7206 0.0216584462474 ko04068 FoxO signaling pathway 5/531 167/7206 0.0239624219592 ko04922 Glucagon signaling pathway 3/531 128/7206 0.0248677386922 ko04024 cAMP signaling pathway 11/531 279/7206 0.0254960811607 ko04142 Lysosome 4/531 151/7206 0.02560370077 ko05130 Pathogenic Escherichia coli infection 11/531 77/7206 0.0273409052436 ko00510 N-Glycan biosynthesis 8/531 50/7206 0.0283699029483 ko04261 Adrenergic signaling in cardiomyocytes 7/531 205/7206 0.0286516496857 ko04512 ECM-receptor interaction 1/531 79/7206 0.0291159508335 ko00564 Glycerophospholipid metabolism 2/531 99/7206 0.0328969648705 ko05203 Viral carcinogenesis 30/531 277/7206 0.0336757660086 ko04066 HIF-1 signaling pathway 3/531 123/7206 0.0345236479981 ko00970 Aminoacyl-tRNA biosynthesis 7/531 44/7206 0.0401751067814 ko03022 Basal transcription factors 7/531 44/7206 0.0401751067814 ko04217 Necroptosis 6/531 178/7206 0.0404003455627 ko00010 Glycolysis / Gluconeogenesis 1/531 74/7206 0.0422054229039 ko05168 Herpes simplex infection 21/531 182/7206 0.0422587281974 ko04923 Regulation of lipolysis in adipocytes 1/531 77/7206 0.0438705903792 ko04380 Osteoclast differentiation 4/531 134/7206 0.0452836185507 ko04970 Salivary secretion 2/531 95/7206 0.0463186530296 ko04064 NF-kappa B signaling pathway 2/531 96/7206 0.0466461298265 ko04911 Insulin secretion 3/531 117/7206 0.047281353327 ko04390 Hippo signaling pathway 21/531 188/7206 0.047789090249 ko05100 Bacterial invasion of epithelial cells 13/531 99/7206 0.0487205255924