ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 40/264 191/7206 4.18172875641e-20 ko05164 Influenza A 33/264 167/7206 6.48659014987e-16 ko04621 NOD-like receptor signaling pathway 31/264 157/7206 5.39249901498e-15 ko05340 Primary immunodeficiency 15/264 30/7206 1.83940728832e-14 ko05162 Measles 25/264 120/7206 7.58280174132e-13 ko04380 Osteoclast differentiation 26/264 134/7206 1.48488610028e-12 ko05168 Herpes simplex infection 30/264 182/7206 2.22057724671e-12 ko04650 Natural killer cell mediated cytotoxicity 22/264 97/7206 3.14427269147e-12 ko05140 Leishmaniasis 19/264 75/7206 1.23740819341e-11 ko05145 Toxoplasmosis 24/264 126/7206 1.70554742946e-11 ko05321 Inflammatory bowel disease (IBD) 16/264 56/7206 7.49213492098e-11 ko04064 NF-kappa B signaling pathway 20/264 96/7206 1.64754752157e-10 ko04612 Antigen processing and presentation 18/264 77/7206 1.86363931006e-10 ko04620 Toll-like receptor signaling pathway 20/264 100/7206 3.57975884098e-10 ko04659 Th17 cell differentiation 20/264 106/7206 1.0655661587e-09 ko04217 Necroptosis 26/264 178/7206 1.10897336148e-09 ko04658 Th1 and Th2 cell differentiation 19/264 96/7206 1.2111691447e-09 ko04660 T cell receptor signaling pathway 21/264 124/7206 3.17366192453e-09 ko05152 Tuberculosis 26/264 187/7206 3.27821222891e-09 ko05330 Allograft rejection 10/264 24/7206 4.58473923919e-09 ko05332 Graft-versus-host disease 8/264 18/7206 9.29373206991e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/264 191/7206 1.00063922524e-07 ko04630 Jak-STAT signaling pathway 19/264 132/7206 2.70644477592e-07 ko05150 Staphylococcus aureus infection 10/264 36/7206 4.0226460811e-07 ko05133 Pertussis 15/264 87/7206 4.76363197582e-07 ko05320 Autoimmune thyroid disease 9/264 29/7206 5.4606318074e-07 ko04062 Chemokine signaling pathway 23/264 201/7206 1.0191336879e-06 ko05310 Asthma 7/264 17/7206 1.16171970707e-06 ko05161 Hepatitis B 21/264 173/7206 1.16530467162e-06 ko04622 RIG-I-like receptor signaling pathway 12/264 62/7206 1.91859611733e-06 ko05160 Hepatitis C 19/264 153/7206 2.71653245334e-06 ko05323 Rheumatoid arthritis 14/264 89/7206 3.61225468585e-06 ko04672 Intestinal immune network for IgA production 9/264 37/7206 5.2413480325e-06 ko04668 TNF signaling pathway 16/264 120/7206 6.76069991615e-06 ko04623 Cytosolic DNA-sensing pathway 9/264 41/7206 1.29778154712e-05 ko04940 Type I diabetes mellitus 8/264 32/7206 1.42808325477e-05 ko04662 B cell receptor signaling pathway 13/264 88/7206 1.63752097063e-05 ko04640 Hematopoietic cell lineage 11/264 64/7206 1.71521847255e-05 ko05142 Chagas disease (American trypanosomiasis) 16/264 130/7206 1.90345265274e-05 ko04145 Phagosome 16/264 162/7206 0.0002733385402 ko04210 Apoptosis 17/264 180/7206 0.000302214292822 ko04664 Fc epsilon RI signaling pathway 10/264 77/7206 0.000461223126842 ko04666 Fc gamma R-mediated phagocytosis 13/264 122/7206 0.000493079417641 ko04610 Complement and coagulation cascades 10/264 79/7206 0.000567991767077 ko03050 Proteasome 8/264 54/7206 0.000702474003743 ko05416 Viral myocarditis 8/264 55/7206 0.000796464864103 ko05144 Malaria 7/264 45/7206 0.00112498546056 ko04657 IL-17 signaling pathway 10/264 87/7206 0.00121995082829 ko05034 Alcoholism 1/264 238/7206 0.00234987637943 ko05169 Epstein-Barr virus infection 16/264 206/7206 0.00397695517885 ko05166 HTLV-I infection 20/264 292/7206 0.00622405376366 ko04514 Cell adhesion molecules (CAMs) 11/264 130/7206 0.00795684430296 ko04611 Platelet activation 13/264 163/7206 0.00880077138332 ko05131 Shigellosis 8/264 82/7206 0.00998391279281 ko04670 Leukocyte transendothelial migration 12/264 151/7206 0.0126055382246 ko04310 Wnt signaling pathway 1/264 181/7206 0.0150878883396 ko04728 Dopaminergic synapse 1/264 185/7206 0.015349957268 ko04390 Hippo signaling pathway 1/264 188/7206 0.0157709468552 ko00051 Fructose and mannose metabolism 5/264 42/7206 0.0178587855571 ko04530 Tight junction 2/264 228/7206 0.0180818715972 ko05134 Legionellosis 7/264 74/7206 0.0181930810052 ko04080 Neuroactive ligand-receptor interaction 7/264 423/7206 0.022234687605 ko05016 Huntington's disease 2/264 215/7206 0.0252095411339 ko05132 Salmonella infection 8/264 98/7206 0.0268140720925 ko00590 Arachidonic acid metabolism 5/264 52/7206 0.0407106518738 ko05222 Small cell lung cancer 7/264 89/7206 0.0440906575441 ko04724 Glutamatergic synapse 1/264 152/7206 0.0458185864838 ko05012 Parkinson's disease 1/264 155/7206 0.0469301625626 ko04360 Axon guidance 3/264 233/7206 0.0493891019272