ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 20/131 191/7206 1.64658301284e-10 ko04621 NOD-like receptor signaling pathway 18/131 157/7206 3.30217897145e-10 ko05164 Influenza A 17/131 167/7206 6.76271129038e-09 ko04380 Osteoclast differentiation 14/131 134/7206 1.14978894962e-07 ko05168 Herpes simplex infection 15/131 182/7206 9.00036651581e-07 ko04064 NF-kappa B signaling pathway 11/131 96/7206 1.1159623676e-06 ko05152 Tuberculosis 15/131 187/7206 1.27191848449e-06 ko04668 TNF signaling pathway 12/131 120/7206 1.56150237233e-06 ko04620 Toll-like receptor signaling pathway 11/131 100/7206 1.6850458921e-06 ko05161 Hepatitis B 14/131 173/7206 2.65187901689e-06 ko05162 Measles 11/131 120/7206 1.01457241198e-05 ko04622 RIG-I-like receptor signaling pathway 8/131 62/7206 1.42728208376e-05 ko04672 Intestinal immune network for IgA production 6/131 37/7206 4.71066336604e-05 ko04658 Th1 and Th2 cell differentiation 9/131 96/7206 5.61501388567e-05 ko04660 T cell receptor signaling pathway 10/131 124/7206 7.87500830049e-05 ko04623 Cytosolic DNA-sensing pathway 6/131 41/7206 8.58415889154e-05 ko04217 Necroptosis 12/131 178/7206 8.7505082025e-05 ko04210 Apoptosis 12/131 180/7206 9.74389832154e-05 ko05160 Hepatitis C 11/131 153/7206 9.80357792951e-05 ko05131 Shigellosis 8/131 82/7206 0.000110969929883 ko05167 Kaposi's sarcoma-associated herpesvirus infection 12/131 191/7206 0.000171291333928 ko05340 Primary immunodeficiency 5/131 30/7206 0.000181932850888 ko04662 B cell receptor signaling pathway 8/131 88/7206 0.000182684861021 ko05323 Rheumatoid arthritis 8/131 89/7206 0.000197701499792 ko05166 HTLV-I infection 15/131 292/7206 0.000248711372119 ko05145 Toxoplasmosis 9/131 126/7206 0.000450806026954 ko05321 Inflammatory bowel disease (IBD) 6/131 56/7206 0.000496043773988 ko04630 Jak-STAT signaling pathway 9/131 132/7206 0.000633796261741 ko05144 Malaria 5/131 45/7206 0.00125426107005 ko05132 Salmonella infection 7/131 98/7206 0.00195982536538 ko04612 Antigen processing and presentation 6/131 77/7206 0.00265532603903 ko04659 Th17 cell differentiation 7/131 106/7206 0.00306303988215 ko05133 Pertussis 6/131 87/7206 0.00488123088137 ko05120 Epithelial cell signaling in Helicobacter pylori infection 6/131 92/7206 0.00640448023537 ko04650 Natural killer cell mediated cytotoxicity 6/131 97/7206 0.00824769719592 ko05330 Allograft rejection 3/131 24/7206 0.0089896269091 ko04145 Phagosome 8/131 162/7206 0.00916855985453 ko05142 Chagas disease (American trypanosomiasis) 7/131 130/7206 0.00928492560741 ko05134 Legionellosis 5/131 74/7206 0.010888183467 ko05140 Leishmaniasis 5/131 75/7206 0.011500008473 ko05169 Epstein-Barr virus infection 9/131 206/7206 0.0125142770888 ko05320 Autoimmune thyroid disease 3/131 29/7206 0.0151957009115 ko05416 Viral myocarditis 4/131 55/7206 0.0174114046974 ko04657 IL-17 signaling pathway 5/131 87/7206 0.0207420590802 ko04666 Fc gamma R-mediated phagocytosis 6/131 122/7206 0.0234214156182 ko05150 Staphylococcus aureus infection 3/131 36/7206 0.0270928438688 ko05100 Bacterial invasion of epithelial cells 5/131 99/7206 0.0338577490722 ko05146 Amoebiasis 5/131 99/7206 0.0338577490722 ko05332 Graft-versus-host disease 2/131 18/7206 0.0414977532663 ko04932 Non-alcoholic fatty liver disease (NAFLD) 7/131 182/7206 0.0476401693739