ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 31/243 167/7206 3.13570931182e-15 ko04621 NOD-like receptor signaling pathway 28/243 157/7206 2.16654769273e-13 ko05340 Primary immunodeficiency 13/243 30/7206 3.81536836998e-12 ko05162 Measles 23/243 120/7206 7.25290257965e-12 ko04380 Osteoclast differentiation 23/243 134/7206 7.74429006638e-11 ko04217 Necroptosis 26/243 178/7206 1.78495513325e-10 ko04064 NF-kappa B signaling pathway 19/243 96/7206 2.9464279721e-10 ko05145 Toxoplasmosis 21/243 126/7206 9.45280864506e-10 ko05168 Herpes simplex infection 25/243 182/7206 1.54242124741e-09 ko04658 Th1 and Th2 cell differentiation 18/243 96/7206 2.21858237007e-09 ko05140 Leishmaniasis 16/243 75/7206 2.47343497017e-09 ko04660 T cell receptor signaling pathway 20/243 124/7206 4.37141832818e-09 ko05152 Tuberculosis 24/243 187/7206 1.32314556157e-08 ko04620 Toll-like receptor signaling pathway 17/243 100/7206 2.94502100724e-08 ko04659 Th17 cell differentiation 17/243 106/7206 7.21274340719e-08 ko04060 Cytokine-cytokine receptor interaction 23/243 191/7206 9.02459030212e-08 ko04650 Natural killer cell mediated cytotoxicity 16/243 97/7206 1.1809115964e-07 ko04612 Antigen processing and presentation 14/243 77/7206 2.13712939336e-07 ko05321 Inflammatory bowel disease (IBD) 12/243 56/7206 2.46518453425e-07 ko04623 Cytosolic DNA-sensing pathway 10/243 41/7206 7.05641027315e-07 ko05133 Pertussis 14/243 87/7206 1.01828240439e-06 ko05161 Hepatitis B 20/243 173/7206 1.25336817318e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/243 191/7206 1.54489104946e-06 ko04630 Jak-STAT signaling pathway 17/243 132/7206 1.81103885054e-06 ko05150 Staphylococcus aureus infection 9/243 36/7206 2.0639469842e-06 ko04622 RIG-I-like receptor signaling pathway 11/243 62/7206 5.67382833862e-06 ko05330 Allograft rejection 7/243 24/7206 9.63247213272e-06 ko04672 Intestinal immune network for IgA production 8/243 37/7206 2.46377034064e-05 ko04662 B cell receptor signaling pathway 12/243 88/7206 3.47781497599e-05 ko05320 Autoimmune thyroid disease 7/243 29/7206 3.75946297899e-05 ko05142 Chagas disease (American trypanosomiasis) 14/243 130/7206 0.000112982204731 ko05323 Rheumatoid arthritis 11/243 89/7206 0.000182485381618 ko05310 Asthma 5/243 17/7206 0.000185674362874 ko04668 TNF signaling pathway 13/243 120/7206 0.000186849591783 ko05160 Hepatitis C 15/243 153/7206 0.000187332304299 ko05332 Graft-versus-host disease 5/243 18/7206 0.000250067845805 ko04210 Apoptosis 16/243 180/7206 0.000356155655176 ko05131 Shigellosis 10/243 82/7206 0.000399615198121 ko03050 Proteasome 8/243 54/7206 0.000404646427044 ko04666 Fc gamma R-mediated phagocytosis 12/243 122/7206 0.000797559272057 ko04145 Phagosome 14/243 162/7206 0.001093048756 ko04062 Chemokine signaling pathway 16/243 201/7206 0.00119178066555 ko04610 Complement and coagulation cascades 9/243 79/7206 0.00127568090296 ko05132 Salmonella infection 10/243 98/7206 0.00163342175128 ko05416 Viral myocarditis 7/243 55/7206 0.00231763048853 ko05134 Legionellosis 8/243 74/7206 0.00328605584522 ko05144 Malaria 6/243 45/7206 0.00373649617911 ko04940 Type I diabetes mellitus 5/243 32/7206 0.00399818790564 ko05034 Alcoholism 1/243 238/7206 0.00510225433036 ko05166 HTLV-I infection 19/243 292/7206 0.006888088153 ko04080 Neuroactive ligand-receptor interaction 5/243 423/7206 0.00758947281786 ko05169 Epstein-Barr virus infection 14/243 206/7206 0.0104203574602 ko04514 Cell adhesion molecules (CAMs) 10/243 130/7206 0.0121876391218 ko04664 Fc epsilon RI signaling pathway 7/243 77/7206 0.0147176360996 ko04670 Leukocyte transendothelial migration 11/243 151/7206 0.0182026843467 ko04728 Dopaminergic synapse 1/243 185/7206 0.0218556669776 ko04611 Platelet activation 11/243 163/7206 0.0251268240596 ko04917 Prolactin signaling pathway 7/243 87/7206 0.0270020411413 ko00966 Glucosinolate biosynthesis 1/243 1/7206 0.033721898418 ko04020 Calcium signaling pathway 3/243 265/7206 0.0360404516517 ko05020 Prion diseases 4/243 40/7206 0.0446377828728 ko05130 Pathogenic Escherichia coli infection 6/243 77/7206 0.0448535564123 ko00140 Steroid hormone biosynthesis 4/243 41/7206 0.0482048357022