ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/389 191/7206 2.74877658566e-16 ko04380 Osteoclast differentiation 32/389 134/7206 3.87976896447e-13 ko05164 Influenza A 35/389 167/7206 1.80911711671e-12 ko04621 NOD-like receptor signaling pathway 33/389 157/7206 7.40225295814e-12 ko05340 Primary immunodeficiency 14/389 30/7206 9.34367282893e-11 ko05140 Leishmaniasis 21/389 75/7206 1.98706481555e-10 ko04064 NF-kappa B signaling pathway 23/389 96/7206 8.19305524699e-10 ko04659 Th17 cell differentiation 24/389 106/7206 1.20628530055e-09 ko05321 Inflammatory bowel disease (IBD) 17/389 56/7206 2.79069198777e-09 ko05162 Measles 25/389 120/7206 3.44079476414e-09 ko05152 Tuberculosis 32/389 187/7206 3.96741465974e-09 ko04650 Natural killer cell mediated cytotoxicity 22/389 97/7206 5.82382181694e-09 ko05145 Toxoplasmosis 25/389 126/7206 9.89581228166e-09 ko04620 Toll-like receptor signaling pathway 22/389 100/7206 1.06490345637e-08 ko04217 Necroptosis 30/389 178/7206 1.78692136447e-08 ko04672 Intestinal immune network for IgA production 13/389 37/7206 2.951301156e-08 ko05168 Herpes simplex infection 30/389 182/7206 3.02560135463e-08 ko04658 Th1 and Th2 cell differentiation 20/389 96/7206 1.32021938518e-07 ko05320 Autoimmune thyroid disease 11/389 29/7206 1.41310387256e-07 ko04660 T cell receptor signaling pathway 23/389 124/7206 1.4481718365e-07 ko05330 Allograft rejection 10/389 24/7206 1.85967366426e-07 ko05150 Staphylococcus aureus infection 12/389 36/7206 1.98822821473e-07 ko05133 Pertussis 18/389 87/7206 6.30665344616e-07 ko05323 Rheumatoid arthritis 18/389 89/7206 8.99282847833e-07 ko05161 Hepatitis B 26/389 173/7206 1.63618721077e-06 ko05332 Graft-versus-host disease 8/389 18/7206 1.8218601234e-06 ko04612 Antigen processing and presentation 16/389 77/7206 2.5119598422e-06 ko04622 RIG-I-like receptor signaling pathway 14/389 62/7206 3.80989991067e-06 ko05142 Chagas disease (American trypanosomiasis) 21/389 130/7206 5.25508017845e-06 ko04062 Chemokine signaling pathway 27/389 201/7206 9.1667824575e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/389 191/7206 1.05694965526e-05 ko05144 Malaria 11/389 45/7206 1.8923218686e-05 ko04623 Cytosolic DNA-sensing pathway 10/389 41/7206 4.64512134546e-05 ko04668 TNF signaling pathway 18/389 120/7206 6.86062792746e-05 ko04145 Phagosome 21/389 162/7206 0.000153278071475 ko05310 Asthma 6/389 17/7206 0.000177124928035 ko04940 Type I diabetes mellitus 8/389 32/7206 0.00022441330924 ko04662 B cell receptor signaling pathway 14/389 88/7206 0.000233100450906 ko04630 Jak-STAT signaling pathway 18/389 132/7206 0.000238510797852 ko04610 Complement and coagulation cascades 13/389 79/7206 0.000275122263556 ko04611 Platelet activation 20/389 163/7206 0.000563941863934 ko04210 Apoptosis 21/389 180/7206 0.0006968849815 ko05132 Salmonella infection 14/389 98/7206 0.000722777212692 ko04666 Fc gamma R-mediated phagocytosis 16/389 122/7206 0.000810714657084 ko04723 Retrograde endocannabinoid signaling 1/389 175/7206 0.00105256694696 ko05131 Shigellosis 12/389 82/7206 0.00137948432707 ko03013 RNA transport 1/389 166/7206 0.00153838010138 ko05160 Hepatitis C 18/389 153/7206 0.00161266164322 ko05034 Alcoholism 3/389 238/7206 0.00183501570818 ko05134 Legionellosis 11/389 74/7206 0.00190161874379 ko04640 Hematopoietic cell lineage 10/389 64/7206 0.00206708067638 ko04664 Fc epsilon RI signaling pathway 11/389 77/7206 0.00262969131743 ko00120 Primary bile acid biosynthesis 5/389 20/7206 0.00352928044522 ko04728 Dopaminergic synapse 2/389 185/7206 0.00436794930517 ko04514 Cell adhesion molecules (CAMs) 15/389 130/7206 0.00487029593137 ko04916 Melanogenesis 1/389 142/7206 0.00722408964973 ko04080 Neuroactive ligand-receptor interaction 11/389 423/7206 0.00732044977026 ko03050 Proteasome 8/389 54/7206 0.00786186377568 ko05416 Viral myocarditis 8/389 55/7206 0.00877967719041 ko04670 Leukocyte transendothelial migration 16/389 151/7206 0.00928771254128 ko04713 Circadian entrainment 1/389 136/7206 0.0107438350532 ko05166 HTLV-I infection 26/389 292/7206 0.0112692011342 ko04724 Glutamatergic synapse 2/389 152/7206 0.0173658728534 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/389 135/7206 0.018439294004 ko04310 Wnt signaling pathway 3/389 181/7206 0.018646100342 ko05169 Epstein-Barr virus infection 19/389 206/7206 0.0187032730509 ko05202 Transcriptional misregulation in cancer 18/389 188/7206 0.0200292621551 ko00590 Arachidonic acid metabolism 7/389 52/7206 0.0207313141332 ko04911 Insulin secretion 1/389 117/7206 0.0212800642779 ko04360 Axon guidance 5/389 233/7206 0.0254466481227 ko04657 IL-17 signaling pathway 10/389 87/7206 0.0259922558758 ko00281 Geraniol degradation 2/389 5/7206 0.0260709340427 ko04144 Endocytosis 28/389 342/7206 0.0263951317528 ko04726 Serotonergic synapse 2/389 137/7206 0.0343450270734 ko04114 Oocyte meiosis 2/389 139/7206 0.0347015533652 ko04137 Mitophagy - animal 9/389 82/7206 0.0421503323365 ko04720 Long-term potentiation 1/389 99/7206 0.0438757196953 ko05016 Huntington's disease 5/389 215/7206 0.0446306619655 ko04925 Aldosterone synthesis and secretion 1/389 105/7206 0.0456063247689 ko00511 Other glycan degradation 4/389 26/7206 0.0487642039905